Jakob R. Winther

Jakob R. Winther

Professor

ORCID: 0000-0001-6995-9154

Publication year:
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  1. 2023
  2. Published

    Global analysis of multi-mutants to improve protein function

    Johansson, Kristoffer Enøe, Lindorff-Larsen, Kresten & Winther, Jakob R., 2023, In: Journal of Molecular Biology. 435, 8, 15 p., 168034.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2022
  4. Published

    Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system

    Koivisto, J. M., Poulsen, N. R., Larsen, B. S., Weibull, M. G. M., Stein, Amelie, Doro, F., Winther, Jakob R., Lindorff-Larsen, Kresten & Willemoës, Martin, 2022, In: The Biochemical journal. 479, 4, p. 479-501

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Engineering Bifidobacterium longum Endo-α-N-acetylgalactosaminidase for Neu5Acα2-3Ga1β1-3Ga1NAc reactivity on Fetuin

    Hansen, D. K., Hansen, A. L., Koivisto, J. M., Shuoker, B., Abou Hachem, M., Winther, Jakob R. & Willemoës, Martin, 2022, In: Archives of Biochemistry and Biophysics. 725, 8 p., 109280.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Increasing protein stability by inferring substitution effects from high-throughput experiments

    Norrild, R. K., Johansson, Kristoffer Enøe, O'Shea, Charlotte, Morth, J. P., Lindorff-Larsen, Kresten & Winther, Jakob R., 2022, In: Cell Reports Methods. 2, 11, 11 p., 100333.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The functional role of the autolysis loop in the regulation of factor X upon hemostatic response

    Bonde, A. C., Lund, J., Hansen, J. J., Winther, Jakob R., Nielsen, P. F., Zahn, S., Tiainen, P., Olsen, O. H., Petersen, H. H. & Rose Bjelke, J., 2022, In: Journal of Thrombosis and Haemostasis. 20, 3, p. 589-599 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. 2021
  9. Published

    VM i molekylære puslespil

    Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 16 Apr 2021, In: Weekendavisen: Ideer. 15, p. 11

    Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication

  10. Published

    Molekylære stavefejl

    Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 28 Jan 2021, In: Weekendavisen, Ideer.

    Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication

  11. Published

    Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry

    Abramsson, M. L., Sahin, C., Hopper, J. T. S., Branca, R. M. M., Danielsson, J., Xu, M., Chandler, S. A., Österlund, N., Ilag, L. L., Leppert, A., Costeira-Paulo, J., Lang, L., Teilum, K., Laganowsky, A., Benesch, J. L. P., Oliveberg, M., Robinson, C. V., Marklund, E. G., Allison, T. M., Winther, J. R. & 1 others, Landreh, M., 2021, In: JACS Au. 1, 12, p. 2385-2393 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Charge Interactions in a Highly Charge-Depleted Protein

    Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Yong, Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Computational and Experimental Assessment of Backbone Templates for Computational Redesign of the Thioredoxin Fold

    Marin, Frederikke Isa, Johansson, Kristoffer Enøe, O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: The Journal of Physical Chemistry B. 125, 40, p. 11141-11149

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Computational and experimental assessment of backbone templates for computational protein design

    Marin, Frederikke Isa, Johansson, K. E., O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, 15 p.

    Research output: Working paper › Preprint › Research

  15. Published

    Flash properties of Gaussia luciferase are the result of covalent inhibition after a limited number of cycles

    Dijkema, F. M., Nordentoft, M. K., Didriksen, A. K., Corneliussen, A. S., Willemoës, Martin & Winther, Jakob R., 2021, In: Protein Science. 30, 3, p. 638-649 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Rational Protein Engineering to Increase the Activity and Stability of IsPETase Using the PROSS Algorithm

    Rennison, A., Winther, Jakob R. & Varrone, C., 2021, In: Polymers. 13, 22, 11 p., 3884.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Substitutional landscape of a split fluorescent protein fragment using high-density peptide microarrays

    Antonescu, O. N., Rasmussen, A., Damm, N. A. M., Heidemann, Ditte Fogh, Popov, R., Nesterov-Mueller, A., Johansson, Kristoffer Enøe & Winther, Jakob R., 2021, In: PLoS ONE. 16, 2, 17 p., e0241461.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2020
  19. Published

    Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water

    Kampmeyer, Caroline, Johansen, Jens Vilstrup, Holmberg, Christian, Karlson, M., Andersen, Sarah Gersing, Nunes Bordallo, Heloisa, Kragelund, Birthe Brandt, Lerche, M. H., Jourdain, I., Winther, Jakob R. & Hartmann-Petersen, Rasmus, 2020, In: A C S Synthetic Biology. 9, 4, p. 733-748 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2019
  21. Published

    Improving folding properties of computationally designed proteins

    Bjerre, B., Nissen, J., Madsen, M., Kamarauskaite, J., Norrild, R. K., Holm, Peter Christoffer, Nordentoft, M. K., O'Shea, Charlotte, Willemoës, Martin, Johansson, Kristoffer Enøe & Winther, Jakob R., 13 Dec 2019, In: Protein Engineering Design and Selection (Print). 32, 3, p. 145-151 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Shining light on split fluorescent protein fitness landscapes using peptide array-based deep substitutional scanning

    ANTONESCU, O., Johansson, Kristoffer Enøe & Winther, Jakob R., 30 Jun 2019.

    Research output: Contribution to conference › Poster › Research › peer-review

  23. Published

    Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses

    Hadrup, N., Knudsen, K. B., Berthing, T., Wolff, H., Bengtson, S., Kofoed, Christian, Espersen, R., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Wedin, I., Nuopponen, M., Alenius, H., Norppa, H., Wallin, H. & Vogel, U., 2019, In: Environmental Toxicology and Pharmacology. 66, p. 116-125 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Steady state kinetic analysis of O-linked GalNAc glycan release catalyzed by endo-α-N-acetylgalactosaminidase

    Hansen, D. K., Winther, Jakob R. & Willemoës, Martin, 2019, In: Carbohydrate Research. 480, p. 54-60

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 2018
  26. Published

    Comprehensive mapping of GFP structure-function relationship using high-density peptide arrays

    Antonescu, O., Johansson, Kristoffer Enøe & Winther, Jakob R., 10 Jul 2018.

    Research output: Contribution to conference › Poster › Research › peer-review

  27. Published

    A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

    Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Can a Charged Surfactant Unfold an Uncharged Protein?

    Højgaard, C., Sørensen, H. V., Pedersen, J. S., Winther, Jakob R. & Otzen, D. E., 2018, In: Biophysical Journal. 115, 11, p. 2081-2086 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Editorial overview: A perspective on protein evolution

    Hoecker, B. & Winther, Jakob R., 2018, In: Current Opinion in Structural Biology. 48, p. viii-ix 2 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  30. Published

    Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month

    Ilves, M., Vilske, S., Aimonen, K., Lindberg, H. K., Pesonen, S., Wedin, I., Nuopponen, M., Vanhala, E., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Vogel, U., Wolff, H., Norppa, H., Savolainen, K. & Alenius, H., 2018, In: Nanotoxicology. 12, 7, p. 729-746 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Protein evolution: Hacking an enzyme

    Johansson, Kristoffer Enøe & Winther, Jakob R., 2018, In: Nature Chemical Biology. 14, 3, p. 202-204 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  32. Published

    Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants

    Santner, P., Martins, J. M. D. S., Kampmeyer, Caroline, Hartmann-Petersen, Rasmus, Laursen, J. S., Stein, Amelie, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5957-5968

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. 2017
  34. Published

    Evolution i overhalingsbanen

    Abildgaard, A. B., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Winther, Jakob R., 15 Dec 2017, In: Weekendavisen. 2017, 50, p. Ideer: 13 1 p.

    Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication

  35. Published

    Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip

    Ponsero, A. J., Igbaria, A., Darch, M. A., Miled, S., Outten, C. E., Winther, Jakob R., Palais, G., D'Autréaux, B., Delaunay-Moisan, A. & Toledano, M. B., 21 Sep 2017, In: Molecular Cell. 67, 6, p. 962-973.e5 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Positive staining for cellulose in oral pulse granuloma

    Virkkunen, S., Wolff, H., Haglund, C., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Vogel, U. & Hagström, J., Apr 2017, In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123, 4, p. 464-467 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Exploring the antigenic response to multiplexed immunizations in a chicken model of antibody production

    Kousted, T. M., Kalliokoski, Otto, Christensen, S. K., Winther, Jakob R. & Hau, Jann, Mar 2017, In: Heliyon. 3, 3, 19 p., e00267.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2016
  39. Published

    A soluble, folded protein without charged amino acid residues

    Højgaard, C., Kofoed, Christian, Espersen, R., Johansson, Kristoffer Enøe, Villa, M., Willemoës, Martin, Lindorff-Larsen, Kresten, Teilum, Kaare & Winther, Jakob R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template

    Johansson, Kristoffer Enøe, Johansen, Nicolai Tidemand, Christensen, S., Horowitz, S., Bardwell, J. C. A., Olsen, Johan Gotthardt, Willemoës, Martin, Lindorff-Larsen, Kresten, Ferkinghoff-Borg, J., Hamelryck, Thomas Wim & Winther, Jakob R., 2016, In: Journal of Molecular Biology. 428, 21, p. 4361-4377 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. 2015
  42. Published

    Mutational analysis of divalent metal ion binding in the active site of class II α-mannosidase from Sulfolobus solfataricus

    Hansen, D., Webb, H., Nielsen, J. W., Harris, P., Winther, Jakob R. & Willemoës, Martin, 2015, In: Biochemistry. 54, 11, p. 2032-2039 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Visualization of nanofibrillar cellulose in biological tissues using a biotinylated carbohydrate binding module of β-1,4-Glycanase

    Knudsen, K. B., Kofoed, Christian, Espersen, R., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Wedin, I., Nuopponen, M., Vilske, S., Aimonen, K., Weydahl, I. E. K., Alenius, H., Norppa, H., Wolff, H., Wallin, E. H. R. & Vogel, U., 2015, In: Chemical Research in Toxicology. 28, 8, p. 1627-1635 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. 2014
  45. Published

    In Silico prediction of mutant HIV-1 proteases cleaving a target sequence

    Jensen, Jan Halborg, Willemoës, Martin, Winther, Jakob R. & De Vico, L., 2014, In: P L o S One. 9, 5, 11 p., 5.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Catalytic site interactions in yeast OMP synthase

    Hansen, M. R., Barr, E. W., Jensen, K. F., Willemoës, Martin, Grubmeyer, C. & Winther, Jakob R., 2014, In: Archives of Biochemistry and Biophysics. 542, p. 28-38 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes

    Christensen, Caspar Elo, Karlsson, M., Winther, Jakob R., Jensen, P. R. & Lerche, M. H., 2014, In: The Journal of Biological Chemistry. 289, 4, p. 2344-2352 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Quantification of thiols and disulfides

    Winther, Jakob R. & Thorpe, C., 2014, In: BBA General Subjects. 1840, 2, p. 838-846 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Rapid TaqMan-based quantification of chlorophyll d-containing cyanobacteria in the genus Acaryochloris

    Behrendt, L., Nielsen, J. L., Sørensen, Søren Johannes, Larkum, A. W. D., Winther, Jakob R. & Kühl, Michael, 2014, In: Applied and Environmental Microbiology. 80, 10, p. 3244-3249 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    The pKa value and accessibility of cysteine residues are key determinants for protein substrate discrimination by glutaredoxin

    Jensen, K. S., Pedersen, J. T., Winther, Jakob R. & Teilum, Kaare, 2014, In: Biochemistry. 53, 15, p. 2533-2540 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. 2013
  52. Published

    Intracellular glutathione pools are heterogeneously concentrated

    Montero, D., Tachibana, C., Winther, Jakob R. & Appenzeller-Herzog, C., 2013, In: Redox Biology. 1, 1, p. 508-513 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Quantifying changes in the cellular thiol-disulfide status during differentiation of B cells into antibody-secreting plasma cells

    Hansen, R. R. E., Otsu, M., Braakman, I. & Winther, Jakob R., 2013, In: International Journal of Cell Biology. 2013, 10 p., 898563.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Redox control: a black hole for oxidized glutathione

    Winther, Jakob R. & Jakob, U., 2013, In: Nature Chemical Biology. 9, 2, p. 69-70 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Saccharopepsin

    Winther, Jakob R., Webb, H. & Kay, J., 2013, Handbook of Proteolytic Enzymes. Rawlings, N. D. & Salvesen, G. (eds.). Third Edition ed. Academic Press, Vol. 1. p. 128-133 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  56. 2012
  57. Published

    A fluorescent probe which allows highly specific thiol labeling at low pH

    Nielsen, J. W., Jensen, K. S., Hansen, R. R. E., Gotfredsen, C. H. & Winther, Jakob R., 2012, In: Analytical Biochemistry. 421, 1, p. 115-120 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Metal-ion dependent catalytic properties of Sulfolobus solfataricus class II α-mannosidase

    Nielsen, J. W., Poulsen, N. R., Johnsson, A. M. S., Winther, Jakob R., Stipp, S. L. S. & Willemoës, Martin, 2012, In: Biochemistry. 51, 40, p. 8039-8046 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Polysaccharide effects on calcite growth: the influence of composition and branching

    Nielsen, J. W., Sand, Karina Krarup, Pedersen, C. S., Lakshtanov, L. Z., Winther, Jakob R., Willemoës, Martin & Stipp, S. L. S., 2012, In: Crystal Growth & Design. 12, 10, p. 4906-4910 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region

    Christensen, L. C., Jensen, N. W., Lages Lino Vala, A., Kamarauskaite, J., Johansson, L. C., Winther, Jakob R., Hofmann, K., Teilum, Kaare & Ellgaard, Lars, 2012, In: Journal of Biological Chemistry. 287, 31, p. 26388-26399 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. 2011
  62. Published

    Millisecond dynamics in glutaredoxin during catalytic turnover is dependent on substrate binding and absent in the resting states

    Jensen, K. S., Winther, Jakob R. & Teilum, Kaare, 2011, In: Journal of the American Chemical Society. 133, 9, p. 3034-42 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Trisulfides in Proteins

    Nielsen, R. W., Tachibana, C., Hansen, N. E. & Winther, Jakob R., 2011, In: Antioxidants & Redox Signaling. 15, 1, p. 67-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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