PhD defense: Rehannah Borup

Application of Microarray technology in research and diagnostics: differential expression catalogs and molecular signatures

Supervision
Anders Krogh, Professor, University of Copenhagen
Ole Winther, Associate Professor, University of Copenhagen

Exam Committee
Dr. Johan Smitz, Professor, Centre for Reproductive Medicine, Teaching Hospital of the VUB
Chris Workman, Associate professor, Center for Biological Sequence Analysis Department of Systems Biology, Technical University of Denmark
Thomas Wim Hamelryck, Associate professor, Department of Biology, Computational and RNA Biology, University of Copenhagen

Abstract
The overall purpose of the thesis work was to evaluate the use of microarray analysis to investigate the transcriptome of human cancers and human follicular cells and define the correlation between expression of human genes and specific cancer types as well as the developmental competence of the oocyte and its surrounding follicular cells. Furthermore use the retrieved information about gene expression and disease and function to formulate and specify classification models, which may aid in the translation of genomic research into clinical application.