Breast cancer by proxy: can the microenvironment be both the cause and consequence?

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Breast cancer by proxy: can the microenvironment be both the cause and consequence? / Rønnov-Jessen, Lone; Bissell, Mina J.

I: Trends in Molecular Medicine, Bind 15, Nr. 1, 2009, s. 5-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rønnov-Jessen, L & Bissell, MJ 2009, 'Breast cancer by proxy: can the microenvironment be both the cause and consequence?', Trends in Molecular Medicine, bind 15, nr. 1, s. 5-13. https://doi.org/10.1016/j.molmed.2008.11.001

APA

Rønnov-Jessen, L., & Bissell, M. J. (2009). Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends in Molecular Medicine, 15(1), 5-13. https://doi.org/10.1016/j.molmed.2008.11.001

Vancouver

Rønnov-Jessen L, Bissell MJ. Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends in Molecular Medicine. 2009;15(1):5-13. https://doi.org/10.1016/j.molmed.2008.11.001

Author

Rønnov-Jessen, Lone ; Bissell, Mina J. / Breast cancer by proxy: can the microenvironment be both the cause and consequence?. I: Trends in Molecular Medicine. 2009 ; Bind 15, Nr. 1. s. 5-13.

Bibtex

@article{20d45a70dbee11dd9473000ea68e967b,
title = "Breast cancer by proxy: can the microenvironment be both the cause and consequence?",
abstract = "Breast cancer is one of the most clear-cut examples of a solid tumor in which systemic cues play a decisive part in its development. The breast tissue is constantly subjected to changes in hormone levels and modifications in the microenvironment. This scenario is even more striking during tumor development because of the dramatic loss or aberration of basement membrane (BM) and myoepithelial cells and the gain of peritumoral myofibroblasts. We suggest that the microenvironment, defined here as all components of the mammary gland other than luminal and/or tumor epithelial cells, might be instrumental in maintaining organ integrity and in promoting, and at times even initiating, breast cancer development. As such, the tumor microenvironment and its constituents, alone or in combination, might serve as promising targets for therapy.",
author = "Lone R{\o}nnov-Jessen and Bissell, {Mina J}",
year = "2009",
doi = "10.1016/j.molmed.2008.11.001",
language = "English",
volume = "15",
pages = "5--13",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Ltd. * Trends Journals",
number = "1",

}

RIS

TY - JOUR

T1 - Breast cancer by proxy: can the microenvironment be both the cause and consequence?

AU - Rønnov-Jessen, Lone

AU - Bissell, Mina J

PY - 2009

Y1 - 2009

N2 - Breast cancer is one of the most clear-cut examples of a solid tumor in which systemic cues play a decisive part in its development. The breast tissue is constantly subjected to changes in hormone levels and modifications in the microenvironment. This scenario is even more striking during tumor development because of the dramatic loss or aberration of basement membrane (BM) and myoepithelial cells and the gain of peritumoral myofibroblasts. We suggest that the microenvironment, defined here as all components of the mammary gland other than luminal and/or tumor epithelial cells, might be instrumental in maintaining organ integrity and in promoting, and at times even initiating, breast cancer development. As such, the tumor microenvironment and its constituents, alone or in combination, might serve as promising targets for therapy.

AB - Breast cancer is one of the most clear-cut examples of a solid tumor in which systemic cues play a decisive part in its development. The breast tissue is constantly subjected to changes in hormone levels and modifications in the microenvironment. This scenario is even more striking during tumor development because of the dramatic loss or aberration of basement membrane (BM) and myoepithelial cells and the gain of peritumoral myofibroblasts. We suggest that the microenvironment, defined here as all components of the mammary gland other than luminal and/or tumor epithelial cells, might be instrumental in maintaining organ integrity and in promoting, and at times even initiating, breast cancer development. As such, the tumor microenvironment and its constituents, alone or in combination, might serve as promising targets for therapy.

U2 - 10.1016/j.molmed.2008.11.001

DO - 10.1016/j.molmed.2008.11.001

M3 - Journal article

C2 - 19091631

VL - 15

SP - 5

EP - 13

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 1

ER -

ID: 9537709