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Genome-wide analysis identifies 12 loci influencing human reproductive behavior. / Barban, Nicola; Jansen, Rick; de Vlaming, Ronald; Vaez, Ahmad; Mandemakers, Jornt J; Tropf, Felix C; Shen, Xia; Wilson, James F; Chasman, Daniel I; Nolte, Ilja M; Tragante, Vinicius; van der Laan, Sander W; Perry, John R B; Kong, Augustine; Ahluwalia, Tarun Veer Singh; Albrecht, Eva; Yerges-Armstrong, Laura; Atzmon, Gil; Auro, Kirsi; Ayers, Kristin; Bakshi, Andrew; Ben-Avraham, Danny; Berger, Klaus; Bergman, Aviv; Bertram, Lars; Bielak, Lawrence F; Bjornsdottir, Gyda; Bonder, Marc Jan; Broer, Linda; Bui, Minh; Barbieri, Caterina; Cavadino, Alana; Chavarro, Jorge E; Turman, Constance; Concas, Maria Pina; Cordell, Heather J; Davies, Gail; Eibich, Peter; Eriksson, Nicholas; Esko, Tõnu; Eriksson, Joel; Falahi, Fahimeh; Felix, Janine F; Fontana, Mark Alan; Franke, Lude; Gandin, Ilaria; Gaskins, Audrey J; Bisgaard, Hans; Bønnelykke, Klaus; Waage, Johannes; BIOS Consortium.
I:
Nature Genetics, Bind 48, Nr. 12, 12.2016, s. 1462-1472.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Barban, N, Jansen, R, de Vlaming, R, Vaez, A, Mandemakers, JJ, Tropf, FC, Shen, X, Wilson, JF, Chasman, DI, Nolte, IM, Tragante, V, van der Laan, SW, Perry, JRB, Kong, A
, Ahluwalia, TVS, Albrecht, E, Yerges-Armstrong, L, Atzmon, G, Auro, K, Ayers, K, Bakshi, A, Ben-Avraham, D, Berger, K, Bergman, A, Bertram, L, Bielak, LF, Bjornsdottir, G, Bonder, MJ, Broer, L, Bui, M, Barbieri, C, Cavadino, A, Chavarro, JE, Turman, C, Concas, MP, Cordell, HJ, Davies, G, Eibich, P, Eriksson, N, Esko, T, Eriksson, J, Falahi, F, Felix, JF, Fontana, MA, Franke, L, Gandin, I, Gaskins, AJ, Bisgaard, H
, Bønnelykke, K, Waage, J & BIOS Consortium 2016, '
Genome-wide analysis identifies 12 loci influencing human reproductive behavior',
Nature Genetics, bind 48, nr. 12, s. 1462-1472.
https://doi.org/10.1038/ng.3698APA
Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., Shen, X., Wilson, J. F., Chasman, D. I., Nolte, I. M., Tragante, V., van der Laan, S. W., Perry, J. R. B., Kong, A.
, Ahluwalia, T. V. S., Albrecht, E., Yerges-Armstrong, L., Atzmon, G., Auro, K., ... BIOS Consortium (2016).
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
Nature Genetics,
48(12), 1462-1472.
https://doi.org/10.1038/ng.3698Vancouver
Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC o.a.
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
Nature Genetics. 2016 dec.;48(12):1462-1472.
https://doi.org/10.1038/ng.3698Author
Barban, Nicola ; Jansen, Rick ; de Vlaming, Ronald ; Vaez, Ahmad ; Mandemakers, Jornt J ; Tropf, Felix C ; Shen, Xia ; Wilson, James F ; Chasman, Daniel I ; Nolte, Ilja M ; Tragante, Vinicius ; van der Laan, Sander W ; Perry, John R B ; Kong, Augustine ; Ahluwalia, Tarun Veer Singh ; Albrecht, Eva ; Yerges-Armstrong, Laura ; Atzmon, Gil ; Auro, Kirsi ; Ayers, Kristin ; Bakshi, Andrew ; Ben-Avraham, Danny ; Berger, Klaus ; Bergman, Aviv ; Bertram, Lars ; Bielak, Lawrence F ; Bjornsdottir, Gyda ; Bonder, Marc Jan ; Broer, Linda ; Bui, Minh ; Barbieri, Caterina ; Cavadino, Alana ; Chavarro, Jorge E ; Turman, Constance ; Concas, Maria Pina ; Cordell, Heather J ; Davies, Gail ; Eibich, Peter ; Eriksson, Nicholas ; Esko, Tõnu ; Eriksson, Joel ; Falahi, Fahimeh ; Felix, Janine F ; Fontana, Mark Alan ; Franke, Lude ; Gandin, Ilaria ; Gaskins, Audrey J ; Bisgaard, Hans ; Bønnelykke, Klaus ; Waage, Johannes ; BIOS Consortium. / Genome-wide analysis identifies 12 loci influencing human reproductive behavior. I: Nature Genetics. 2016 ; Bind 48, Nr. 12. s. 1462-1472.
Bibtex
@article{8a1a3e64d90f43989aa85f9db6b780cf,
title = "Genome-wide analysis identifies 12 loci influencing human reproductive behavior",
abstract = "The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.",
author = "Nicola Barban and Rick Jansen and {de Vlaming}, Ronald and Ahmad Vaez and Mandemakers, {Jornt J} and Tropf, {Felix C} and Xia Shen and Wilson, {James F} and Chasman, {Daniel I} and Nolte, {Ilja M} and Vinicius Tragante and {van der Laan}, {Sander W} and Perry, {John R B} and Augustine Kong and Ahluwalia, {Tarun Veer Singh} and Eva Albrecht and Laura Yerges-Armstrong and Gil Atzmon and Kirsi Auro and Kristin Ayers and Andrew Bakshi and Danny Ben-Avraham and Klaus Berger and Aviv Bergman and Lars Bertram and Bielak, {Lawrence F} and Gyda Bjornsdottir and Bonder, {Marc Jan} and Linda Broer and Minh Bui and Caterina Barbieri and Alana Cavadino and Chavarro, {Jorge E} and Constance Turman and Concas, {Maria Pina} and Cordell, {Heather J} and Gail Davies and Peter Eibich and Nicholas Eriksson and T{\~o}nu Esko and Joel Eriksson and Fahimeh Falahi and Felix, {Janine F} and Fontana, {Mark Alan} and Lude Franke and Ilaria Gandin and Gaskins, {Audrey J} and Hans Bisgaard and Klaus B{\o}nnelykke and Johannes Waage and {BIOS Consortium}",
year = "2016",
month = dec,
doi = "10.1038/ng.3698",
language = "English",
volume = "48",
pages = "1462--1472",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "12",
}
RIS
TY - JOUR
T1 - Genome-wide analysis identifies 12 loci influencing human reproductive behavior
AU - Barban, Nicola
AU - Jansen, Rick
AU - de Vlaming, Ronald
AU - Vaez, Ahmad
AU - Mandemakers, Jornt J
AU - Tropf, Felix C
AU - Shen, Xia
AU - Wilson, James F
AU - Chasman, Daniel I
AU - Nolte, Ilja M
AU - Tragante, Vinicius
AU - van der Laan, Sander W
AU - Perry, John R B
AU - Kong, Augustine
AU - Ahluwalia, Tarun Veer Singh
AU - Albrecht, Eva
AU - Yerges-Armstrong, Laura
AU - Atzmon, Gil
AU - Auro, Kirsi
AU - Ayers, Kristin
AU - Bakshi, Andrew
AU - Ben-Avraham, Danny
AU - Berger, Klaus
AU - Bergman, Aviv
AU - Bertram, Lars
AU - Bielak, Lawrence F
AU - Bjornsdottir, Gyda
AU - Bonder, Marc Jan
AU - Broer, Linda
AU - Bui, Minh
AU - Barbieri, Caterina
AU - Cavadino, Alana
AU - Chavarro, Jorge E
AU - Turman, Constance
AU - Concas, Maria Pina
AU - Cordell, Heather J
AU - Davies, Gail
AU - Eibich, Peter
AU - Eriksson, Nicholas
AU - Esko, Tõnu
AU - Eriksson, Joel
AU - Falahi, Fahimeh
AU - Felix, Janine F
AU - Fontana, Mark Alan
AU - Franke, Lude
AU - Gandin, Ilaria
AU - Gaskins, Audrey J
AU - Bisgaard, Hans
AU - Bønnelykke, Klaus
AU - Waage, Johannes
AU - BIOS Consortium
PY - 2016/12
Y1 - 2016/12
N2 - The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
AB - The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
U2 - 10.1038/ng.3698
DO - 10.1038/ng.3698
M3 - Journal article
C2 - 27798627
VL - 48
SP - 1462
EP - 1472
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 12
ER -
