Role of autophagy in disease resistance and hypersensitive response-associated cell death
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Role of autophagy in disease resistance and hypersensitive response-associated cell death. / Hofius, Daniel; Munch, David; Bressendorff, Simon; Mundy, John; Petersen, Morten.
I: Cell Death and Differentiation, Bind 18, Nr. 8, 2011, s. 1257-1262.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Role of autophagy in disease resistance and hypersensitive response-associated cell death
AU - Hofius, Daniel
AU - Munch, David
AU - Bressendorff, Simon
AU - Mundy, John
AU - Petersen, Morten
PY - 2011
Y1 - 2011
N2 - Ancient autophagy pathways are emerging as key defense modules in host eukaryotic cells against microbial pathogens. Apart from actively eliminating intracellular intruders, autophagy is also responsible for cell survival, for example by reducing the deleterious effects of endoplasmic reticulum stress. At the same time, autophagy can contribute to cellular suicide. The concurrent engagement of autophagy in these processes during infection may sometimes mask its contribution to differing pro-survival and pro-death decisions. The importance of autophagy in innate immunity in mammals is well documented, but how autophagy contributes to plant innate immunity and cell death is not that clear. A few research reports have appeared recently to shed light on the roles of autophagy in plant-pathogen interactions and in disease-associated host cell death. We present a first attempt to reconcile the results of this research.
AB - Ancient autophagy pathways are emerging as key defense modules in host eukaryotic cells against microbial pathogens. Apart from actively eliminating intracellular intruders, autophagy is also responsible for cell survival, for example by reducing the deleterious effects of endoplasmic reticulum stress. At the same time, autophagy can contribute to cellular suicide. The concurrent engagement of autophagy in these processes during infection may sometimes mask its contribution to differing pro-survival and pro-death decisions. The importance of autophagy in innate immunity in mammals is well documented, but how autophagy contributes to plant innate immunity and cell death is not that clear. A few research reports have appeared recently to shed light on the roles of autophagy in plant-pathogen interactions and in disease-associated host cell death. We present a first attempt to reconcile the results of this research.
KW - Animals
KW - Autophagy
KW - Cell Death
KW - Cell Survival
KW - Disease Resistance
KW - Host-Pathogen Interactions
KW - Plant Cells
KW - Plants
U2 - 10.1038/cdd.2011.43
DO - 10.1038/cdd.2011.43
M3 - Journal article
C2 - 21527936
VL - 18
SP - 1257
EP - 1262
JO - Cell Differentiation and Development
JF - Cell Differentiation and Development
SN - 1350-9047
IS - 8
ER -
ID: 44159476