A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression

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A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression. / Li, Xuyang; Lozano-Madueno, Cristina; Martinez-Alvarez, Laura; Peng, Xu.

I: Nucleic acids symposium series, Bind 51, Nr. 4, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Li, X, Lozano-Madueno, C, Martinez-Alvarez, L & Peng, X 2023, 'A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression', Nucleic acids symposium series, bind 51, nr. 4. https://doi.org/10.1093/nar/gkad011

APA

Li, X., Lozano-Madueno, C., Martinez-Alvarez, L., & Peng, X. (2023). A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression. Nucleic acids symposium series, 51(4). https://doi.org/10.1093/nar/gkad011

Vancouver

Li X, Lozano-Madueno C, Martinez-Alvarez L, Peng X. A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression. Nucleic acids symposium series. 2023;51(4). https://doi.org/10.1093/nar/gkad011

Author

Li, Xuyang ; Lozano-Madueno, Cristina ; Martinez-Alvarez, Laura ; Peng, Xu. / A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression. I: Nucleic acids symposium series. 2023 ; Bind 51, Nr. 4.

Bibtex

@article{7bd7ce9cbecb465eb7b2757dbeccf99d,
title = "A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression",
abstract = "Cell cycle regulation is crucial for all living organisms and is often targeted by viruses to facilitate their own propagation, yet cell cycle progression control is largely underexplored in archaea. In this work, we reveal a cell cycle regulator (aCcr1) carrying a ribbon-helix-helix (RHH) domain and ubiquitous in the Thermoproteota of the order Sulfolobales and their viruses. Overexpression of several aCcr1 members including gp21 of rudivirus SIRV2 and its host homolog SiL_0190 of Saccharolobus islandicus LAL14/1 results in impairment of cell division, evidenced by growth retardation, cell enlargement and an increase in cellular DNA content. Additionally, both gp21 and SiL_0190 can bind to the motif AGTATTA conserved in the promoter of several genes involved in cell division, DNA replication and cellular metabolism thereby repressing or inducing their transcription. Our results suggest that aCcr1 silences cell division and drives progression to the S-phase in Sulfolobales, a function exploited by viruses to facilitate viral propagation.",
keywords = "HYPERTHERMOPHILIC ARCHAEON, CHROMOSOME SEGREGATION, GENE-EXPRESSION, DNA-BINDING, DIVISION, GENOME, ALIGNMENT, INSIGHTS, PRODUCT, DOMAIN",
author = "Xuyang Li and Cristina Lozano-Madueno and Laura Martinez-Alvarez and Xu Peng",
year = "2023",
doi = "10.1093/nar/gkad011",
language = "English",
volume = "51",
journal = "Nucleic acids symposium series",
issn = "0261-3166",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression

AU - Li, Xuyang

AU - Lozano-Madueno, Cristina

AU - Martinez-Alvarez, Laura

AU - Peng, Xu

PY - 2023

Y1 - 2023

N2 - Cell cycle regulation is crucial for all living organisms and is often targeted by viruses to facilitate their own propagation, yet cell cycle progression control is largely underexplored in archaea. In this work, we reveal a cell cycle regulator (aCcr1) carrying a ribbon-helix-helix (RHH) domain and ubiquitous in the Thermoproteota of the order Sulfolobales and their viruses. Overexpression of several aCcr1 members including gp21 of rudivirus SIRV2 and its host homolog SiL_0190 of Saccharolobus islandicus LAL14/1 results in impairment of cell division, evidenced by growth retardation, cell enlargement and an increase in cellular DNA content. Additionally, both gp21 and SiL_0190 can bind to the motif AGTATTA conserved in the promoter of several genes involved in cell division, DNA replication and cellular metabolism thereby repressing or inducing their transcription. Our results suggest that aCcr1 silences cell division and drives progression to the S-phase in Sulfolobales, a function exploited by viruses to facilitate viral propagation.

AB - Cell cycle regulation is crucial for all living organisms and is often targeted by viruses to facilitate their own propagation, yet cell cycle progression control is largely underexplored in archaea. In this work, we reveal a cell cycle regulator (aCcr1) carrying a ribbon-helix-helix (RHH) domain and ubiquitous in the Thermoproteota of the order Sulfolobales and their viruses. Overexpression of several aCcr1 members including gp21 of rudivirus SIRV2 and its host homolog SiL_0190 of Saccharolobus islandicus LAL14/1 results in impairment of cell division, evidenced by growth retardation, cell enlargement and an increase in cellular DNA content. Additionally, both gp21 and SiL_0190 can bind to the motif AGTATTA conserved in the promoter of several genes involved in cell division, DNA replication and cellular metabolism thereby repressing or inducing their transcription. Our results suggest that aCcr1 silences cell division and drives progression to the S-phase in Sulfolobales, a function exploited by viruses to facilitate viral propagation.

KW - HYPERTHERMOPHILIC ARCHAEON

KW - CHROMOSOME SEGREGATION

KW - GENE-EXPRESSION

KW - DNA-BINDING

KW - DIVISION

KW - GENOME

KW - ALIGNMENT

KW - INSIGHTS

KW - PRODUCT

KW - DOMAIN

U2 - 10.1093/nar/gkad011

DO - 10.1093/nar/gkad011

M3 - Journal article

C2 - 36727447

VL - 51

JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

SN - 0261-3166

IS - 4

ER -

ID: 336461768