Amino acids and the changing face of the α-cell

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Glucagon has long been defined by its glucogenic action and as a result α-cells have been characterised based largely on their interaction with glucose. Recent findings have challenged this preconception, bringing to the fore the significant role glucagon plays in amino acid breakdown and underlining the importance of amino acids in glucagon secretion. The challenge that remains is defining the mechanism that underlie these effects - understanding which amino acids are most important, how they act on the α-cell and how their actions integrate with other fuels such as glucose and fatty acids. This review will describe the current relationship between amino acids and glucagon and how we can use this knowledge to redefine the α-cell.
OriginalsprogEngelsk
Artikelnummer171039
TidsskriftPeptides
Vol/bind166
Antal sider7
ISSN0196-9781
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
We thank colleagues and friends for fruitful discussions in this area. The authors are supported by grants from the Swedish Foundation for Strategic Research , Sweden ( LUDC-IRC15-0067 ), the Swedish Research Council , Sweden (Project grant to LE - 2019-01406 ), SFO-EXODIAB , Sweden ( 2009-1039 ), Swedish Society for Medical Research , Sweden (International Postdoctoral Grant to AH - PD20-0073 ), the Novo Nordisk Foundation , Denmark (Emerging Investigator grant to JGK - #0054300 ) and the Danish Independent Research Fund , Denmark (Sapere Aude Fellowship to JGK - 0169-00067B ).

Funding Information:
We thank colleagues and friends for fruitful discussions in this area. The authors are supported by grants from the Swedish Foundation for Strategic Research, Sweden (LUDC-IRC15-0067), the Swedish Research Council, Sweden (Project grant to LE - 2019-01406), SFO-EXODIAB, Sweden (2009-1039), Swedish Society for Medical Research, Sweden (International Postdoctoral Grant to AH - PD20-0073), the Novo Nordisk Foundation, Denmark (Emerging Investigator grant to JGK - #0054300) and the Danish Independent Research Fund, Denmark (Sapere Aude Fellowship to JGK - 0169-00067B).

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© 2023

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