Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells.

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Standard

Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells. / Lambert, Ian Henry; Hoffmann, Else Kay.

I: Journal of Membrane Biology, Bind 142, Nr. 3, 1994, s. 289-298.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lambert, IH & Hoffmann, EK 1994, 'Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells.', Journal of Membrane Biology, bind 142, nr. 3, s. 289-298. https://doi.org/10.1007/BF00233436

APA

Lambert, I. H., & Hoffmann, E. K. (1994). Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells. Journal of Membrane Biology, 142(3), 289-298. https://doi.org/10.1007/BF00233436

Vancouver

Lambert IH, Hoffmann EK. Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells. Journal of Membrane Biology. 1994;142(3):289-298. https://doi.org/10.1007/BF00233436

Author

Lambert, Ian Henry ; Hoffmann, Else Kay. / Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells. I: Journal of Membrane Biology. 1994 ; Bind 142, Nr. 3. s. 289-298.

Bibtex

@article{8bc1cae074ce11dbbee902004c4f4f50,
title = "Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells.",
abstract = "The taurine efflux from Ehrlich ascites tumor cells is stimulated by hypotonic cell swelling. The swelling-activated taurine efflux is unaffected by substitution of gluconate for extracellular Cl– but inhibited by addition of MK196 (anion channel blocker) and 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS; anion channel and anion exchange blocker) and by depolarization of the cell membrane. This is taken to indicate that taurine does not leave the osmotically swollen Ehrlich cells in exchange for extracellular Cl–, i.e., via the anion exchanger but via a MK196- and DIDS-sensitive channel that is potential dependent. An additional stimulation of the swelling-activated taurine efflux is seen after addition of arachidonic acid and oleic acid. Cell swelling also activates a Mini Cl– channel. The Cl– efflux via this Cl– channel, in contrast to the swelling-activated taurine efflux, is unaffected by DIDS and inhibited by arachidonic acid and oleic acid. It is suggested that the swelling-activated Mini Cl– channel and the swelling-activated taurine channel in the Ehrlich cell represent two distinct types of channels.",
author = "Lambert, {Ian Henry} and Hoffmann, {Else Kay}",
note = "Key words Taurine - Anion channel - Indacrinone - Arachidonic acid - Oleic acid - DIDS",
year = "1994",
doi = "10.1007/BF00233436",
language = "English",
volume = "142",
pages = "289--298",
journal = "Journal of Membrane Biology",
issn = "0022-2631",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells.

AU - Lambert, Ian Henry

AU - Hoffmann, Else Kay

N1 - Key words Taurine - Anion channel - Indacrinone - Arachidonic acid - Oleic acid - DIDS

PY - 1994

Y1 - 1994

N2 - The taurine efflux from Ehrlich ascites tumor cells is stimulated by hypotonic cell swelling. The swelling-activated taurine efflux is unaffected by substitution of gluconate for extracellular Cl– but inhibited by addition of MK196 (anion channel blocker) and 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS; anion channel and anion exchange blocker) and by depolarization of the cell membrane. This is taken to indicate that taurine does not leave the osmotically swollen Ehrlich cells in exchange for extracellular Cl–, i.e., via the anion exchanger but via a MK196- and DIDS-sensitive channel that is potential dependent. An additional stimulation of the swelling-activated taurine efflux is seen after addition of arachidonic acid and oleic acid. Cell swelling also activates a Mini Cl– channel. The Cl– efflux via this Cl– channel, in contrast to the swelling-activated taurine efflux, is unaffected by DIDS and inhibited by arachidonic acid and oleic acid. It is suggested that the swelling-activated Mini Cl– channel and the swelling-activated taurine channel in the Ehrlich cell represent two distinct types of channels.

AB - The taurine efflux from Ehrlich ascites tumor cells is stimulated by hypotonic cell swelling. The swelling-activated taurine efflux is unaffected by substitution of gluconate for extracellular Cl– but inhibited by addition of MK196 (anion channel blocker) and 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS; anion channel and anion exchange blocker) and by depolarization of the cell membrane. This is taken to indicate that taurine does not leave the osmotically swollen Ehrlich cells in exchange for extracellular Cl–, i.e., via the anion exchanger but via a MK196- and DIDS-sensitive channel that is potential dependent. An additional stimulation of the swelling-activated taurine efflux is seen after addition of arachidonic acid and oleic acid. Cell swelling also activates a Mini Cl– channel. The Cl– efflux via this Cl– channel, in contrast to the swelling-activated taurine efflux, is unaffected by DIDS and inhibited by arachidonic acid and oleic acid. It is suggested that the swelling-activated Mini Cl– channel and the swelling-activated taurine channel in the Ehrlich cell represent two distinct types of channels.

U2 - 10.1007/BF00233436

DO - 10.1007/BF00233436

M3 - Journal article

VL - 142

SP - 289

EP - 298

JO - Journal of Membrane Biology

JF - Journal of Membrane Biology

SN - 0022-2631

IS - 3

ER -

ID: 264512