Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair
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Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair. / Christensen, Søren T; Pedersen, Stine F; Satir, Peter; Veland, Iben R; Schneider, Linda.
I: Current Topics in Developmental Biology, Bind 85, 2008, s. 261-301.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair
AU - Christensen, Søren T
AU - Pedersen, Stine F
AU - Satir, Peter
AU - Veland, Iben R
AU - Schneider, Linda
PY - 2008
Y1 - 2008
N2 - Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRalpha). We also consider how the primary cilium and the centrosome interact with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration.
AB - Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRalpha). We also consider how the primary cilium and the centrosome interact with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration.
U2 - 10.1016/S0070-2153(08)00810-7
DO - 10.1016/S0070-2153(08)00810-7
M3 - Journal article
C2 - 19147009
VL - 85
SP - 261
EP - 301
JO - Current Topics in Developmental Biology
JF - Current Topics in Developmental Biology
SN - 0070-2153
ER -
ID: 10705914