Cilia and coordination of signaling networks during heart development
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
Cilia and coordination of signaling networks during heart development. / Koefoed, Karen; Veland, Iben Rønn; Pedersen, Lotte Bang; Larsen, Lars Allan; Christensen, Søren Tvorup.
I: Organogenesis, Bind 10, Nr. 1, 2014, s. 108-125.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Cilia and coordination of signaling networks during heart development
AU - Koefoed, Karen
AU - Veland, Iben Rønn
AU - Pedersen, Lotte Bang
AU - Larsen, Lars Allan
AU - Christensen, Søren Tvorup
PY - 2014
Y1 - 2014
N2 - Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart diseases. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development.
AB - Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart diseases. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development.
U2 - 10.4161/org.27483
DO - 10.4161/org.27483
M3 - Review
C2 - 24345806
VL - 10
SP - 108
EP - 125
JO - Organogenesis
JF - Organogenesis
SN - 1547-6278
IS - 1
ER -
ID: 96634465