Convolutional LSTM networks for subcellular localization of proteins

Publikation: Bidrag til bog/antologi/rapportKonferencebidrag i proceedingsForskningfagfællebedømt

  • Søren Kaae Sønderby
  • Casper Kaae Sønderby
  • Henrik Nielsen
  • Winther, Ole

Machine learning is widely used to analyze biological sequence data. Non-sequential models such as SVMs or feed-forward neural networks are often used although they have no natural way of handling sequences of varying length. Recurrent neural networks such as the long short term memory (LSTM) model on the other hand are designed to handle sequences. In this study we demonstrate that LSTM networks predict the subcellular location of proteins given only the protein sequence with high accuracy (0.902) outperforming current state of the art algorithms. We further improve the performance by introducing convolutional filters and experiment with an attention mechanism which lets the LSTM focus on specific parts of the protein. Lastly we introduce new visualizations of both the convolutional filters and the attention mechanisms and show how they can be used to extract biologically relevant knowledge from the LSTM networks.

OriginalsprogEngelsk
TitelAlgorithms for Computational Biology
RedaktørerAdrian-Horia Dediu, Francisco Hernández-Quiroz, Carlos Martín-Vide, David A. Rosenblueth
Antal sider13
ForlagSpringer
Publikationsdato2015
Sider68-80
ISBN (Trykt)978-3-319-21232-6
ISBN (Elektronisk)978-3-319-21233-3
DOI
StatusUdgivet - 2015
Begivenhed2nd International Conference on Algorithms for Computational Biology, AlCoB 2015 - Mexico City, Mexico
Varighed: 4 aug. 20155 aug. 2015

Konference

Konference2nd International Conference on Algorithms for Computational Biology, AlCoB 2015
LandMexico
ByMexico City
Periode04/08/201505/08/2015
NavnLecture notes in computer science
Vol/bind9199
ISSN0302-9743

ID: 153446256