Endocytic control of cellular signaling at the primary cilium

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Endocytic control of cellular signaling at the primary cilium. / Pedersen, Lotte Bang; Mogensen, Johanne Bay; Christensen, Søren Tvorup.

I: Trends in Biochemical Sciences, Bind 41, Nr. 9, 2016, s. 784-797.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Pedersen, LB, Mogensen, JB & Christensen, ST 2016, 'Endocytic control of cellular signaling at the primary cilium', Trends in Biochemical Sciences, bind 41, nr. 9, s. 784-797. https://doi.org/10.1016/j.tibs.2016.06.002

APA

Pedersen, L. B., Mogensen, J. B., & Christensen, S. T. (2016). Endocytic control of cellular signaling at the primary cilium. Trends in Biochemical Sciences, 41(9), 784-797. https://doi.org/10.1016/j.tibs.2016.06.002

Vancouver

Pedersen LB, Mogensen JB, Christensen ST. Endocytic control of cellular signaling at the primary cilium. Trends in Biochemical Sciences. 2016;41(9):784-797. https://doi.org/10.1016/j.tibs.2016.06.002

Author

Pedersen, Lotte Bang ; Mogensen, Johanne Bay ; Christensen, Søren Tvorup. / Endocytic control of cellular signaling at the primary cilium. I: Trends in Biochemical Sciences. 2016 ; Bind 41, Nr. 9. s. 784-797.

Bibtex

@article{a65726f02e6f4b5b888e9ef8c6cf2bd5,
title = "Endocytic control of cellular signaling at the primary cilium",
abstract = "Primary cilia are dynamic signaling organelles that project from the cell surface to sense diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause diseases (ciliopathies) that affect multiple organs in developing and adult organisms. Cilia-mediated signaling involves the orchestrated movement of signaling proteins in and out of the ciliary compartment, including movement of receptors such as the Sonic Hedgehog (Shh) receptor Patched 1 (PTCH1), Smoothened (SMO), and various other G protein-coupled receptors (GPCRs), as well as transforming growth factor b (TGF-b) receptors I and II (TGFb-RI/II). We provide here a current understanding of trafficking events associated with cilia-mediated signaling, with emphasis on the involvement of clathrindependent receptor-mediated endocytosis in regulating ciliary Shh and TGF-b signaling.",
author = "Pedersen, {Lotte Bang} and Mogensen, {Johanne Bay} and Christensen, {S{\o}ren Tvorup}",
year = "2016",
doi = "10.1016/j.tibs.2016.06.002",
language = "English",
volume = "41",
pages = "784--797",
journal = "Trends in Biochemical Sciences",
issn = "0968-0004",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Endocytic control of cellular signaling at the primary cilium

AU - Pedersen, Lotte Bang

AU - Mogensen, Johanne Bay

AU - Christensen, Søren Tvorup

PY - 2016

Y1 - 2016

N2 - Primary cilia are dynamic signaling organelles that project from the cell surface to sense diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause diseases (ciliopathies) that affect multiple organs in developing and adult organisms. Cilia-mediated signaling involves the orchestrated movement of signaling proteins in and out of the ciliary compartment, including movement of receptors such as the Sonic Hedgehog (Shh) receptor Patched 1 (PTCH1), Smoothened (SMO), and various other G protein-coupled receptors (GPCRs), as well as transforming growth factor b (TGF-b) receptors I and II (TGFb-RI/II). We provide here a current understanding of trafficking events associated with cilia-mediated signaling, with emphasis on the involvement of clathrindependent receptor-mediated endocytosis in regulating ciliary Shh and TGF-b signaling.

AB - Primary cilia are dynamic signaling organelles that project from the cell surface to sense diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause diseases (ciliopathies) that affect multiple organs in developing and adult organisms. Cilia-mediated signaling involves the orchestrated movement of signaling proteins in and out of the ciliary compartment, including movement of receptors such as the Sonic Hedgehog (Shh) receptor Patched 1 (PTCH1), Smoothened (SMO), and various other G protein-coupled receptors (GPCRs), as well as transforming growth factor b (TGF-b) receptors I and II (TGFb-RI/II). We provide here a current understanding of trafficking events associated with cilia-mediated signaling, with emphasis on the involvement of clathrindependent receptor-mediated endocytosis in regulating ciliary Shh and TGF-b signaling.

U2 - 10.1016/j.tibs.2016.06.002

DO - 10.1016/j.tibs.2016.06.002

M3 - Review

C2 - 27364476

VL - 41

SP - 784

EP - 797

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 9

ER -

ID: 164597298