GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B
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GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B. / Schalk, Felix; Fricke, Janis; Um, Soohyun; Conlon, Benjamin H.; Maus, Hannah; Jäger, Nils; Heinzel, Thorsten; Schirmeister, Tanja; Poulsen, Michael; Beemelmanns, Christine.
I: RSC Advances, Bind 31, Nr. 11, 2021, s. 18748-18756.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B
AU - Schalk, Felix
AU - Fricke, Janis
AU - Um, Soohyun
AU - Conlon, Benjamin H.
AU - Maus, Hannah
AU - Jäger, Nils
AU - Heinzel, Thorsten
AU - Schirmeister, Tanja
AU - Poulsen, Michael
AU - Beemelmanns, Christine
N1 - Funding Information: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy - EXC 2051 with Project-ID 390713860 and CRC 1127 with Project-ID 239748522 to CB and TH. Funded by the European Research Council (ERC-CoG - 771349) and The Danish Council for Independent Research (DFF - 7014-00178) to MP. We thank the Humboldt Foundation for a postdoctoral fellowship to SU, and Mrs Heike Heinecke (Hans Kn?ll Institute) for recording NMR spectra. Funding Information: Funded by the Deutsche Forschungsgemeinscha (DFG, German Research Foundation) under Germany's Excellence Strategy – EXC 2051 with Project-ID 390713860 and CRC 1127 with Project-ID 239748522 to CB and TH. Funded by the European Research Council (ERC-CoG – 771349) and The Danish Council for Independent Research (DFF – 7014-00178) to MP. We thank the Humboldt Foundation for a postdoctoral fellowship to SU, and Mrs Heike Heinecke (Hans Knöll Institute) for recording NMR spectra. Publisher Copyright: © The Royal Society of Chemistry 2021.
PY - 2021
Y1 - 2021
N2 - Targeted HRMS2-GNPS-based metabolomic analysis ofPseudoxylariasp. X187, a fungal antagonist of the fungus-growing termite symbiosis, resulted in the identification of two lipopeptidic congeners of xylacremolides, named xylacremolide C and D, which are built fromd-phenylalanine,l-proline and an acetyl-CoA starter unit elongated by four malonyl-CoA derived ketide units. The putativexyagene cluster was identified from a draft genome generated by Illumina and PacBio sequencing and RNAseq studies. Biological activities of xylacremolide A and B were evaluated and revealed weak histone deacetylase inhibitory (HDACi) and antifungal activities, as well as moderate protease inhibition activity across a panel of nine human, viral and bacterial proteases.
AB - Targeted HRMS2-GNPS-based metabolomic analysis ofPseudoxylariasp. X187, a fungal antagonist of the fungus-growing termite symbiosis, resulted in the identification of two lipopeptidic congeners of xylacremolides, named xylacremolide C and D, which are built fromd-phenylalanine,l-proline and an acetyl-CoA starter unit elongated by four malonyl-CoA derived ketide units. The putativexyagene cluster was identified from a draft genome generated by Illumina and PacBio sequencing and RNAseq studies. Biological activities of xylacremolide A and B were evaluated and revealed weak histone deacetylase inhibitory (HDACi) and antifungal activities, as well as moderate protease inhibition activity across a panel of nine human, viral and bacterial proteases.
U2 - 10.1039/d1ra00997d
DO - 10.1039/d1ra00997d
M3 - Journal article
C2 - 34046176
AN - SCOPUS:85106938119
VL - 31
SP - 18748
EP - 18756
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 11
ER -
ID: 271616053