Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes. / Jie, Zhuye; Chen, Chen; Hao, Lilan; Li, Fei; Song, Liju; Zhang, Xiaowei; Zhu, Jie; Tian, Liu; Tong, Xin; Cai, Kaiye; Zhang, Zhe; Ju, Yanmei; Yu, Xinlei; Li, Ying; Zhou, Hongcheng; Lu, Haorong; Qiu, Xuemei; Li, Qiang; Liao, Yunli; Zhou, Dongsheng; Lian, Heng; Zuo, Yong; Chen, Xiaomin; Rao, Weiqiao; Ren, Yan; Wang, Yuan; Zi, Jin; Wang, Rong; Liu, Na; Wu, Jinghua; Zhang, Wei; Liu, Xiao; Zong, Yang; Liu, Weibin; Xiao, Liang; Hou, Yong; Xu, Xun; Yang, Huanming; Wang, Jian; Kristiansen, Karsten; Jia, Huijue.
I: Genomics, Proteomics and Bioinformatics, Bind 20, Nr. 2, 2022, s. 304-321.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes
AU - Jie, Zhuye
AU - Chen, Chen
AU - Hao, Lilan
AU - Li, Fei
AU - Song, Liju
AU - Zhang, Xiaowei
AU - Zhu, Jie
AU - Tian, Liu
AU - Tong, Xin
AU - Cai, Kaiye
AU - Zhang, Zhe
AU - Ju, Yanmei
AU - Yu, Xinlei
AU - Li, Ying
AU - Zhou, Hongcheng
AU - Lu, Haorong
AU - Qiu, Xuemei
AU - Li, Qiang
AU - Liao, Yunli
AU - Zhou, Dongsheng
AU - Lian, Heng
AU - Zuo, Yong
AU - Chen, Xiaomin
AU - Rao, Weiqiao
AU - Ren, Yan
AU - Wang, Yuan
AU - Zi, Jin
AU - Wang, Rong
AU - Liu, Na
AU - Wu, Jinghua
AU - Zhang, Wei
AU - Liu, Xiao
AU - Zong, Yang
AU - Liu, Weibin
AU - Xiao, Liang
AU - Hou, Yong
AU - Xu, Xun
AU - Yang, Huanming
AU - Wang, Jian
AU - Kristiansen, Karsten
AU - Jia, Huijue
N1 - Publisher Copyright: © 2022
PY - 2022
Y1 - 2022
N2 - The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancy history, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth.
AB - The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancy history, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth.
KW - Breastfeeding
KW - Delivery history
KW - Metagenomic shotgun sequencing
KW - Pregnancy history
KW - Vagino-cervical microbiome
U2 - 10.1016/j.gpb.2021.01.005
DO - 10.1016/j.gpb.2021.01.005
M3 - Journal article
C2 - 34118463
AN - SCOPUS:85112448779
VL - 20
SP - 304
EP - 321
JO - Genomics, Proteomics and Bioinformatics
JF - Genomics, Proteomics and Bioinformatics
SN - 1672-0229
IS - 2
ER -
ID: 332194347