Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Nature Genetics |
Vol/bind | 50 |
Udgave nummer | 2 |
Sider (fra-til) | 172-174 |
Antal sider | 3 |
ISSN | 1061-4036 |
DOI | |
Status | Udgivet - 2018 |
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828106/pdf/emss-75137.pdf
Accepteret manuskript
ID: 191301970