Macrophages contribute to the cyclic activation of adult hair follicle stem cells

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Standard

Macrophages contribute to the cyclic activation of adult hair follicle stem cells. / Castellana, Donatello; Paus, Ralf; Perez-Moreno, Mirna.

I: P L o S Biology, Bind 12, Nr. 12, e1002002, 2014, s. 1-16.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Castellana, D, Paus, R & Perez-Moreno, M 2014, 'Macrophages contribute to the cyclic activation of adult hair follicle stem cells', P L o S Biology, bind 12, nr. 12, e1002002, s. 1-16. https://doi.org/10.1371/journal.pbio.1002002

APA

Castellana, D., Paus, R., & Perez-Moreno, M. (2014). Macrophages contribute to the cyclic activation of adult hair follicle stem cells. P L o S Biology, 12(12), 1-16. [e1002002]. https://doi.org/10.1371/journal.pbio.1002002

Vancouver

Castellana D, Paus R, Perez-Moreno M. Macrophages contribute to the cyclic activation of adult hair follicle stem cells. P L o S Biology. 2014;12(12):1-16. e1002002. https://doi.org/10.1371/journal.pbio.1002002

Author

Castellana, Donatello ; Paus, Ralf ; Perez-Moreno, Mirna. / Macrophages contribute to the cyclic activation of adult hair follicle stem cells. I: P L o S Biology. 2014 ; Bind 12, Nr. 12. s. 1-16.

Bibtex

@article{fe2d7377748d419a9d449d774991f34b,
title = "Macrophages contribute to the cyclic activation of adult hair follicle stem cells",
abstract = "Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle. This process is linked to distinct gene expression, including Wnt transcription. Interestingly, by mimicking this event through the selective induction of macrophage apoptosis in early telogen, we identify a novel involvement of macrophages in stem cell activation in vivo. Importantly, the macrophage-specific pharmacological inhibition of Wnt production delays hair follicle growth. Thus, perifollicular macrophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that regulates their regenerative activity. This finding may have translational implications for skin repair, inflammatory skin diseases and cancer.",
keywords = "Adult Stem Cells, Animals, Apoptosis, Cell Count, Cell Cycle, Cell Differentiation, Female, Hair Follicle, Inflammation, Macrophages, Mice, Skin, Wnt Signaling Pathway, Journal Article, Research Support, Non-U.S. Gov't",
author = "Donatello Castellana and Ralf Paus and Mirna Perez-Moreno",
year = "2014",
doi = "10.1371/journal.pbio.1002002",
language = "English",
volume = "12",
pages = "1--16",
journal = "PLoS Biology",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Macrophages contribute to the cyclic activation of adult hair follicle stem cells

AU - Castellana, Donatello

AU - Paus, Ralf

AU - Perez-Moreno, Mirna

PY - 2014

Y1 - 2014

N2 - Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle. This process is linked to distinct gene expression, including Wnt transcription. Interestingly, by mimicking this event through the selective induction of macrophage apoptosis in early telogen, we identify a novel involvement of macrophages in stem cell activation in vivo. Importantly, the macrophage-specific pharmacological inhibition of Wnt production delays hair follicle growth. Thus, perifollicular macrophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that regulates their regenerative activity. This finding may have translational implications for skin repair, inflammatory skin diseases and cancer.

AB - Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle. This process is linked to distinct gene expression, including Wnt transcription. Interestingly, by mimicking this event through the selective induction of macrophage apoptosis in early telogen, we identify a novel involvement of macrophages in stem cell activation in vivo. Importantly, the macrophage-specific pharmacological inhibition of Wnt production delays hair follicle growth. Thus, perifollicular macrophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that regulates their regenerative activity. This finding may have translational implications for skin repair, inflammatory skin diseases and cancer.

KW - Adult Stem Cells

KW - Animals

KW - Apoptosis

KW - Cell Count

KW - Cell Cycle

KW - Cell Differentiation

KW - Female

KW - Hair Follicle

KW - Inflammation

KW - Macrophages

KW - Mice

KW - Skin

KW - Wnt Signaling Pathway

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1371/journal.pbio.1002002

DO - 10.1371/journal.pbio.1002002

M3 - Journal article

C2 - 25536657

VL - 12

SP - 1

EP - 16

JO - PLoS Biology

JF - PLoS Biology

SN - 1544-9173

IS - 12

M1 - e1002002

ER -

ID: 188368407