New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
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To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Originalsprog | Engelsk |
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Artikelnummer | 10495 |
Tidsskrift | Nature Communications |
Vol/bind | 7 |
Sider (fra-til) | 1-15 |
Antal sider | 15 |
ISSN | 2041-1723 |
DOI | |
Status | Udgivet - 1 feb. 2016 |
Links
- https://www.nature.com/ncomms/2016/160201/ncomms10495/abs/ncomms10495.html
Forlagets udgivne version
ID: 154446872