Origins of the many NPY-family receptors in mammals

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Origins of the many NPY-family receptors in mammals. / Larhammar, D; Wraith, A; Berglund, M M; Holmberg, S K; Lundell, I.

I: Peptides, Bind 22, Nr. 3, 2001, s. 295-307.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Larhammar, D, Wraith, A, Berglund, MM, Holmberg, SK & Lundell, I 2001, 'Origins of the many NPY-family receptors in mammals', Peptides, bind 22, nr. 3, s. 295-307.

APA

Larhammar, D., Wraith, A., Berglund, M. M., Holmberg, S. K., & Lundell, I. (2001). Origins of the many NPY-family receptors in mammals. Peptides, 22(3), 295-307.

Vancouver

Larhammar D, Wraith A, Berglund MM, Holmberg SK, Lundell I. Origins of the many NPY-family receptors in mammals. Peptides. 2001;22(3):295-307.

Author

Larhammar, D ; Wraith, A ; Berglund, M M ; Holmberg, S K ; Lundell, I. / Origins of the many NPY-family receptors in mammals. I: Peptides. 2001 ; Bind 22, Nr. 3. s. 295-307.

Bibtex

@article{3bd3b050e30a11ddb5fc000ea68e967b,
title = "Origins of the many NPY-family receptors in mammals",
abstract = "The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y(2) and Y(5) arose by local duplications and are still present on the same chromosome in human and pig. Duplications of this chromosome led to the Y(1)-like genes Y(4) and y(6). We find evidence for two occasions where receptor subtypes probably arose before peptide genes were duplicated. These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat.",
author = "D Larhammar and A Wraith and Berglund, {M M} and Holmberg, {S K} and I Lundell",
note = "Keywords: Amino Acid Sequence; Amino Acids; Animals; Chromosome Mapping; Databases, Factual; Evolution, Molecular; Gene Duplication; Humans; Ligands; Mice; Models, Genetic; Molecular Sequence Data; Multigene Family; Neuropeptide Y; Phylogeny; Rats; Receptors, Neuropeptide Y; Sequence Homology, Amino Acid; Swine",
year = "2001",
language = "English",
volume = "22",
pages = "295--307",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Origins of the many NPY-family receptors in mammals

AU - Larhammar, D

AU - Wraith, A

AU - Berglund, M M

AU - Holmberg, S K

AU - Lundell, I

N1 - Keywords: Amino Acid Sequence; Amino Acids; Animals; Chromosome Mapping; Databases, Factual; Evolution, Molecular; Gene Duplication; Humans; Ligands; Mice; Models, Genetic; Molecular Sequence Data; Multigene Family; Neuropeptide Y; Phylogeny; Rats; Receptors, Neuropeptide Y; Sequence Homology, Amino Acid; Swine

PY - 2001

Y1 - 2001

N2 - The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y(2) and Y(5) arose by local duplications and are still present on the same chromosome in human and pig. Duplications of this chromosome led to the Y(1)-like genes Y(4) and y(6). We find evidence for two occasions where receptor subtypes probably arose before peptide genes were duplicated. These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat.

AB - The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y(2) and Y(5) arose by local duplications and are still present on the same chromosome in human and pig. Duplications of this chromosome led to the Y(1)-like genes Y(4) and y(6). We find evidence for two occasions where receptor subtypes probably arose before peptide genes were duplicated. These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat.

M3 - Journal article

C2 - 11287083

VL - 22

SP - 295

EP - 307

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 3

ER -

ID: 9746621