Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers. / Rodriguez Morales, David; Ilieva, Mirolyuba; Rennie, Sarah; Uchida, Shizuka.

I: American journal of physiology. Cell physiology, Bind 324, Nr. 4, 2023, s. C837-C842.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Rodriguez Morales, D, Ilieva, M, Rennie, S & Uchida, S 2023, 'Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers', American journal of physiology. Cell physiology, bind 324, nr. 4, s. C837-C842. https://doi.org/10.1152/ajpcell.00024.2023

APA

Rodriguez Morales, D., Ilieva, M., Rennie, S., & Uchida, S. (2023). Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers. American journal of physiology. Cell physiology, 324(4), C837-C842. https://doi.org/10.1152/ajpcell.00024.2023

Vancouver

Rodriguez Morales D, Ilieva M, Rennie S, Uchida S. Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers. American journal of physiology. Cell physiology. 2023;324(4):C837-C842. https://doi.org/10.1152/ajpcell.00024.2023

Author

Rodriguez Morales, David ; Ilieva, Mirolyuba ; Rennie, Sarah ; Uchida, Shizuka. / Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers. I: American journal of physiology. Cell physiology. 2023 ; Bind 324, Nr. 4. s. C837-C842.

Bibtex

@article{df66a6055fce419e9c480b8551f7c6c3,
title = "Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers",
abstract = "Adenosine to inosine (A-to-I) RNA editing is one of the most frequent RNA modifications found in the mammalian transcriptome. Recent studies clearly indicate that RNA editing enzymes, adenosine deaminase acting on RNAs (ADARs), are upregulated in stressed cells and under disease conditions, suggesting that monitoring RNA editing patterns might be useful as diagnostic biomarkers of various diseases. Here, we provide an overview of epitranscriptomics, and focus particularly on the detection and analysis of A-to-I RNA editing using bioinformatic tools in RNA-seq data sets, as well as briefly reviewing the existing evidence about its involvement in disease progressions. Finally, we argue for the detection of RNA editing patterns as part of the routine analysis in RNA-based data sets, with the aim of accelerating the identification of RNA editing targets linked to disease.",
keywords = "diagnostic biomarkers, epitranscriptomics, RNA editing, RNA-seq analysis",
author = "{Rodriguez Morales}, David and Mirolyuba Ilieva and Sarah Rennie and Shizuka Uchida",
year = "2023",
doi = "10.1152/ajpcell.00024.2023",
language = "English",
volume = "324",
pages = "C837--C842",
journal = "American Journal of Physiology: Cell Physiology",
issn = "0363-6143",
publisher = "American Physiological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers

AU - Rodriguez Morales, David

AU - Ilieva, Mirolyuba

AU - Rennie, Sarah

AU - Uchida, Shizuka

PY - 2023

Y1 - 2023

N2 - Adenosine to inosine (A-to-I) RNA editing is one of the most frequent RNA modifications found in the mammalian transcriptome. Recent studies clearly indicate that RNA editing enzymes, adenosine deaminase acting on RNAs (ADARs), are upregulated in stressed cells and under disease conditions, suggesting that monitoring RNA editing patterns might be useful as diagnostic biomarkers of various diseases. Here, we provide an overview of epitranscriptomics, and focus particularly on the detection and analysis of A-to-I RNA editing using bioinformatic tools in RNA-seq data sets, as well as briefly reviewing the existing evidence about its involvement in disease progressions. Finally, we argue for the detection of RNA editing patterns as part of the routine analysis in RNA-based data sets, with the aim of accelerating the identification of RNA editing targets linked to disease.

AB - Adenosine to inosine (A-to-I) RNA editing is one of the most frequent RNA modifications found in the mammalian transcriptome. Recent studies clearly indicate that RNA editing enzymes, adenosine deaminase acting on RNAs (ADARs), are upregulated in stressed cells and under disease conditions, suggesting that monitoring RNA editing patterns might be useful as diagnostic biomarkers of various diseases. Here, we provide an overview of epitranscriptomics, and focus particularly on the detection and analysis of A-to-I RNA editing using bioinformatic tools in RNA-seq data sets, as well as briefly reviewing the existing evidence about its involvement in disease progressions. Finally, we argue for the detection of RNA editing patterns as part of the routine analysis in RNA-based data sets, with the aim of accelerating the identification of RNA editing targets linked to disease.

KW - diagnostic biomarkers

KW - epitranscriptomics

KW - RNA editing

KW - RNA-seq analysis

U2 - 10.1152/ajpcell.00024.2023

DO - 10.1152/ajpcell.00024.2023

M3 - Review

C2 - 36847441

AN - SCOPUS:85151312980

VL - 324

SP - C837-C842

JO - American Journal of Physiology: Cell Physiology

JF - American Journal of Physiology: Cell Physiology

SN - 0363-6143

IS - 4

ER -

ID: 341880559