Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer. / Novak, Ivana; Yu, Haoran; Magni, Lara; Deshar, Ganga.

I: International Journal of Molecular Sciences (Online), Bind 21, Nr. 22, 8781, 2020.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Novak, I, Yu, H, Magni, L & Deshar, G 2020, 'Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer', International Journal of Molecular Sciences (Online), bind 21, nr. 22, 8781. https://doi.org/10.3390/ijms21228781

APA

Novak, I., Yu, H., Magni, L., & Deshar, G. (2020). Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer. International Journal of Molecular Sciences (Online), 21(22), [8781]. https://doi.org/10.3390/ijms21228781

Vancouver

Novak I, Yu H, Magni L, Deshar G. Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer. International Journal of Molecular Sciences (Online). 2020;21(22). 8781. https://doi.org/10.3390/ijms21228781

Author

Novak, Ivana ; Yu, Haoran ; Magni, Lara ; Deshar, Ganga. / Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer. I: International Journal of Molecular Sciences (Online). 2020 ; Bind 21, Nr. 22.

Bibtex

@article{914286f325704b6e99c8ff362450c458,
title = "Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer",
abstract = "The purinergic signaling has an important role in regulating pancreatic exocrine secretion. The exocrine pancreas is also a site of one of the most serious cancer forms, the pancreatic ductal adenocarcinoma (PDAC). Here, we explore how the network of purinergic and adenosine receptors, as well as ecto-nucleotidases regulate normal pancreatic cells and various cells within the pancreatic tumor microenvironment. In particular, we focus on the P2X7 receptor, P2Y2 and P2Y12 receptors, as well as A2 receptors and ecto-nucleotidases CD39 and CD73. Recent studies indicate that targeting one or more of these candidates could present new therapeutic approaches to treat pancreatic cancer. In pancreatic cancer, as much as possible of normal pancreatic function should be preserved, and therefore physiology of purinergic signaling in pancreas needs to be considered.",
keywords = "Fibrosis, Immune cells, Immunotherapy, Inflammation, Ion channels, Pancreatic cancer, Pancreatic stellate cells, Pancreatitis, PDAC, PSC",
author = "Ivana Novak and Haoran Yu and Lara Magni and Ganga Deshar",
year = "2020",
doi = "10.3390/ijms21228781",
language = "English",
volume = "21",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "22",

}

RIS

TY - JOUR

T1 - Purinergic Signaling in Pancreas - From Physiology to Therapeutic Strategies in Pancreatic Cancer

AU - Novak, Ivana

AU - Yu, Haoran

AU - Magni, Lara

AU - Deshar, Ganga

PY - 2020

Y1 - 2020

N2 - The purinergic signaling has an important role in regulating pancreatic exocrine secretion. The exocrine pancreas is also a site of one of the most serious cancer forms, the pancreatic ductal adenocarcinoma (PDAC). Here, we explore how the network of purinergic and adenosine receptors, as well as ecto-nucleotidases regulate normal pancreatic cells and various cells within the pancreatic tumor microenvironment. In particular, we focus on the P2X7 receptor, P2Y2 and P2Y12 receptors, as well as A2 receptors and ecto-nucleotidases CD39 and CD73. Recent studies indicate that targeting one or more of these candidates could present new therapeutic approaches to treat pancreatic cancer. In pancreatic cancer, as much as possible of normal pancreatic function should be preserved, and therefore physiology of purinergic signaling in pancreas needs to be considered.

AB - The purinergic signaling has an important role in regulating pancreatic exocrine secretion. The exocrine pancreas is also a site of one of the most serious cancer forms, the pancreatic ductal adenocarcinoma (PDAC). Here, we explore how the network of purinergic and adenosine receptors, as well as ecto-nucleotidases regulate normal pancreatic cells and various cells within the pancreatic tumor microenvironment. In particular, we focus on the P2X7 receptor, P2Y2 and P2Y12 receptors, as well as A2 receptors and ecto-nucleotidases CD39 and CD73. Recent studies indicate that targeting one or more of these candidates could present new therapeutic approaches to treat pancreatic cancer. In pancreatic cancer, as much as possible of normal pancreatic function should be preserved, and therefore physiology of purinergic signaling in pancreas needs to be considered.

KW - Fibrosis

KW - Immune cells

KW - Immunotherapy

KW - Inflammation

KW - Ion channels

KW - Pancreatic cancer

KW - Pancreatic stellate cells

KW - Pancreatitis

KW - PDAC

KW - PSC

U2 - 10.3390/ijms21228781

DO - 10.3390/ijms21228781

M3 - Review

C2 - 33233631

AN - SCOPUS:85096316937

VL - 21

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 22

M1 - 8781

ER -

ID: 253023960