Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

  • Xiuying Zhang
  • Huanzi Zhong
  • Yufeng Li
  • Zhun Shi
  • Huahui Ren
  • Zhe Zhang
  • Xianghai Zhou
  • Shanmei Tang
  • Xueyao Han
  • Yuxiang Lin
  • Fangming Yang
  • Dan Wang
  • Zuodi Fu
  • Lianying Wang
  • Shida Zhu
  • Yong Hou
  • Xun Xu
  • Huanming Yang
  • Jian Wang
  • Junhua Li
  • Linong Ji

Lifelong sex- and age-related trajectories of the human gut microbiota remain largely unexplored. Using metagenomics, we derived the gut microbial composition of 2,338 adults (26–76 years) from a Han Chinese population-based cohort where metabolic health, hormone levels and aspects of their lifestyles were also recorded. In this cohort, and in three independent cohorts distributed across China, Israel and the Netherlands, we observed sex differences in the gut microbial composition and a shared age-related decrease in sex-dependent differences in gut microbiota. Compared to men, the gut microbiota of premenopausal women exhibited higher microbial diversity and higher abundances of multiple species known to have beneficial effects on host metabolism. We also found consistent sex-independent, age-related gut microbial characteristics across all populations, with the presence of members of the oral microbiota being the strongest indicator of older chronological age. Our findings highlight the existence of sex- and age-related trajectories in the human gut microbiota that are shared between populations of different ethnicities and emphasize the pivotal links between sex hormones, gut microbiota and host metabolism.

OriginalsprogEngelsk
TidsskriftNature Aging
Vol/bind1
Udgave nummer1
Sider (fra-til)87-100
Antal sider14
ISSN2662-8465
DOI
StatusUdgivet - 2021

Bibliografisk note

Funding Information:
We thank all the participants for agreeing to join this study. We are grateful to the research teams from the Department of Endocrinology and Metabolism of Beijing PG Hospital and Peking University People’s Hospital for their contribution to field survey and data collection. We acknowledge the China National Gene Bank for the support of fecal DNA extraction, library preparation and shotgun sequencing. This work was supported by grants from the National Key Research and Development Program (2016YFC1304901), Beijing Science and Technology Committee (D131100005313008) and Shenzhen Municipal Government of China (JCYJ20170817145809215).

Funding Information:
We thank all the participants for agreeing to join this study. We are grateful to the research teams from the Department of Endocrinology and Metabolism of Beijing PG Hospital and Peking University People’s Hospital for their contribution to field survey and data collection. We acknowledge the China National Gene Bank for the support of fecal DNA extraction, library preparation and shotgun sequencing. This work was supported by grants from the National Key Research and Development Program (2016YFC1304901), Beijing Science and Technology Committee (D131100005313008) and Shenzhen Municipal Government of China (JCYJ20170817145809215).

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

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