Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

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Standard

Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men. / Garcia, V P; Mattos, J D; Mentzinger, J; Leite, P E C; Rocha, H N M; Campos, M O; Rocha, M P; Mansur, D E; Secher, Niels H.; Nóbrega, A C L; Fernandes, I A; Rocha, N G.

I: Brazilian Journal of Medical and Biological Research, Bind 55, e12110, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Garcia, VP, Mattos, JD, Mentzinger, J, Leite, PEC, Rocha, HNM, Campos, MO, Rocha, MP, Mansur, DE, Secher, NH, Nóbrega, ACL, Fernandes, IA & Rocha, NG 2022, 'Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men', Brazilian Journal of Medical and Biological Research, bind 55, e12110. https://doi.org/10.1590/1414-431x2022e12110

APA

Garcia, V. P., Mattos, J. D., Mentzinger, J., Leite, P. E. C., Rocha, H. N. M., Campos, M. O., Rocha, M. P., Mansur, D. E., Secher, N. H., Nóbrega, A. C. L., Fernandes, I. A., & Rocha, N. G. (2022). Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men. Brazilian Journal of Medical and Biological Research, 55, [e12110]. https://doi.org/10.1590/1414-431x2022e12110

Vancouver

Garcia VP, Mattos JD, Mentzinger J, Leite PEC, Rocha HNM, Campos MO o.a. Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men. Brazilian Journal of Medical and Biological Research. 2022;55. e12110. https://doi.org/10.1590/1414-431x2022e12110

Author

Garcia, V P ; Mattos, J D ; Mentzinger, J ; Leite, P E C ; Rocha, H N M ; Campos, M O ; Rocha, M P ; Mansur, D E ; Secher, Niels H. ; Nóbrega, A C L ; Fernandes, I A ; Rocha, N G. / Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men. I: Brazilian Journal of Medical and Biological Research. 2022 ; Bind 55.

Bibtex

@article{fba912fa4f82409d9225ec41782eac43,
title = "Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men",
abstract = "In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrixmetalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.",
keywords = "Faculty of Science, Endothelium, Hyperoxia, ICAM-1, Metalloproteinase-9, Vascular remodeling",
author = "Garcia, {V P} and Mattos, {J D} and J Mentzinger and Leite, {P E C} and Rocha, {H N M} and Campos, {M O} and Rocha, {M P} and Mansur, {D E} and Secher, {Niels H.} and N{\'o}brega, {A C L} and Fernandes, {I A} and Rocha, {N G}",
note = "(Ekstern)",
year = "2022",
doi = "10.1590/1414-431x2022e12110",
language = "English",
volume = "55",
journal = "Brazilian Journal of Medical and Biological Research",
issn = "0100-879X",
publisher = "Associacao Brasileira de Divulgacao Cientifica",

}

RIS

TY - JOUR

T1 - Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

AU - Garcia, V P

AU - Mattos, J D

AU - Mentzinger, J

AU - Leite, P E C

AU - Rocha, H N M

AU - Campos, M O

AU - Rocha, M P

AU - Mansur, D E

AU - Secher, Niels H.

AU - Nóbrega, A C L

AU - Fernandes, I A

AU - Rocha, N G

N1 - (Ekstern)

PY - 2022

Y1 - 2022

N2 - In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrixmetalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.

AB - In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrixmetalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.

KW - Faculty of Science

KW - Endothelium

KW - Hyperoxia

KW - ICAM-1

KW - Metalloproteinase-9

KW - Vascular remodeling

UR - https://doi.org/10.1590/1414-431x2022e12110

U2 - 10.1590/1414-431x2022e12110

DO - 10.1590/1414-431x2022e12110

M3 - Journal article

VL - 55

JO - Brazilian Journal of Medical and Biological Research

JF - Brazilian Journal of Medical and Biological Research

SN - 0100-879X

M1 - e12110

ER -

ID: 310835231