Signalling in cell growth and death: adequate nutrition alone may not be sufficient for ciliates. A minireview
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Signalling in cell growth and death: adequate nutrition alone may not be sufficient for ciliates. A minireview. / Wheatley, D N; Christensen, Søren Tvorup; Schousboe, P; Rasmussen, L.
I: Cell Biology International, Bind 17, Nr. 9, 1993, s. 817-23.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Signalling in cell growth and death: adequate nutrition alone may not be sufficient for ciliates. A minireview
AU - Wheatley, D N
AU - Christensen, Søren Tvorup
AU - Schousboe, P
AU - Rasmussen, L
N1 - Keywords: Animals; Ciliophora; Culture Media; Eukaryotic Cells; Growth Substances; Microbiological Techniques; Signal Transduction; Tetrahymena; Tetrahymena pyriformis
PY - 1993
Y1 - 1993
N2 - The initial inoculum level of Tetrahymena in a chemically defined medium determines whether the cells are capable of exponential growth. Below 750 cells ml-1, the cells fail to go into exponential growth and will die within about 20 hours. By adding certain growth stimulants, death can be postponed and the cells begin to grow after a delay which depends on the intensity of the signal. The implication is that autocrine growth factor expression might be required for cells to grow, and that these stimulants either assist its production or lower the cell threshold to its action. The findings in Tetrahymena are reviewed, and the advantages of having a cell system in which all the components of the medium can be carefully controlled is recognised.
AB - The initial inoculum level of Tetrahymena in a chemically defined medium determines whether the cells are capable of exponential growth. Below 750 cells ml-1, the cells fail to go into exponential growth and will die within about 20 hours. By adding certain growth stimulants, death can be postponed and the cells begin to grow after a delay which depends on the intensity of the signal. The implication is that autocrine growth factor expression might be required for cells to grow, and that these stimulants either assist its production or lower the cell threshold to its action. The findings in Tetrahymena are reviewed, and the advantages of having a cell system in which all the components of the medium can be carefully controlled is recognised.
U2 - 10.1006/cbir.1993.1143
DO - 10.1006/cbir.1993.1143
M3 - Journal article
C2 - 8220307
VL - 17
SP - 817
EP - 823
JO - Cell Biology International
JF - Cell Biology International
SN - 1065-6995
IS - 9
ER -
ID: 11256017