Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Grarup, Niels
  • Chrisian S. Rose
  • Ehm A. Andersson
  • Gitte Andersen
  • Arne L. Nielsen
  • Albrechtsen, Anders
  • Jesper O. Clausen
  • Signe S. Rasmussen
  • Torben Jørgensen
  • Annelli Sandbæk
  • Torsten Lauritzen
  • Ole Schmitz
  • Torben Hansen
  • Oluf Pedersen
In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants.
OriginalsprogEngelsk
TidsskriftDiabetes
Vol/bind56
Udgave nummer12
Sider (fra-til)3105-3111
Antal sider7
ISSN0012-1797
DOI
StatusUdgivet - 2007

ID: 38335610