Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines. / Bergeron, Lucie A.; Besenbacher, Søren; Schierup, Mikkel H.; Zhang, Guojie.

I: GigaScience, Bind 10, Nr. 10, giab072, 2021.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Bergeron, LA, Besenbacher, S, Schierup, MH & Zhang, G 2021, 'Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines', GigaScience, bind 10, nr. 10, giab072. https://doi.org/10.1093/gigascience/giab072

APA

Bergeron, L. A., Besenbacher, S., Schierup, M. H., & Zhang, G. (2021). Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines. GigaScience, 10(10), [giab072]. https://doi.org/10.1093/gigascience/giab072

Vancouver

Bergeron LA, Besenbacher S, Schierup MH, Zhang G. Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines. GigaScience. 2021;10(10). giab072. https://doi.org/10.1093/gigascience/giab072

Author

Bergeron, Lucie A. ; Besenbacher, Søren ; Schierup, Mikkel H. ; Zhang, Guojie. / Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines. I: GigaScience. 2021 ; Bind 10, Nr. 10.

Bibtex

@article{a321df022bd14e9a8e820d95f4f9748c,

title = "Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines",

abstract = "The lack of consensus methods to estimate germline mutation rates from pedigrees has led to substantial differences in computational pipelines in the published literature. Here, we answer Susanne Pfeifer's opinion piece discussing the pipeline choices of our recent article estimating the germline mutation rate of rhesus macaques (Macaca mulatta). We acknowledge the differences between the method that we applied and the one preferred by Pfeifer. Yet, we advocate for full transparency and justification of choices as long as rigorous comparison of pipelines remains absent because it is the only way to conclude on best practices for the field. ",

keywords = "computational pipeline, germline mutation rate, NGS sequencing",

author = "Bergeron, {Lucie A.} and S{\o}ren Besenbacher and Schierup, {Mikkel H.} and Guojie Zhang",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press GigaScience.",

year = "2021",

doi = "10.1093/gigascience/giab072",

language = "English",

volume = "10",

journal = "GigaScience",

issn = "2047-217X",

publisher = "Oxford Academic",

number = "10",

}

RIS

TY - JOUR

T1 - Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines

AU - Bergeron, Lucie A.

AU - Besenbacher, Søren

AU - Schierup, Mikkel H.

AU - Zhang, Guojie

PY - 2021

Y1 - 2021

N2 - The lack of consensus methods to estimate germline mutation rates from pedigrees has led to substantial differences in computational pipelines in the published literature. Here, we answer Susanne Pfeifer's opinion piece discussing the pipeline choices of our recent article estimating the germline mutation rate of rhesus macaques (Macaca mulatta). We acknowledge the differences between the method that we applied and the one preferred by Pfeifer. Yet, we advocate for full transparency and justification of choices as long as rigorous comparison of pipelines remains absent because it is the only way to conclude on best practices for the field.

AB - The lack of consensus methods to estimate germline mutation rates from pedigrees has led to substantial differences in computational pipelines in the published literature. Here, we answer Susanne Pfeifer's opinion piece discussing the pipeline choices of our recent article estimating the germline mutation rate of rhesus macaques (Macaca mulatta). We acknowledge the differences between the method that we applied and the one preferred by Pfeifer. Yet, we advocate for full transparency and justification of choices as long as rigorous comparison of pipelines remains absent because it is the only way to conclude on best practices for the field.

KW - computational pipeline

KW - germline mutation rate

KW - NGS sequencing

U2 - 10.1093/gigascience/giab072

DO - 10.1093/gigascience/giab072

M3 - Review

C2 - 34673928

AN - SCOPUS:85119329299

VL - 10

JO - GigaScience

JF - GigaScience

SN - 2047-217X

IS - 10

M1 - giab072

ER -

ID: 286995016

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