T1w/T2w ratio and cognition in 9-to-11-year-old children
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T1w/T2w ratio and cognition in 9-to-11-year-old children. / Langensee, Lara; Rumetshofer, Theodor; Behjat, Hamid; Novén, Mikael; Li, Ping; Mårtensson, Johan.
I: Brain Sciences, Bind 12, Nr. 5, 599, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - T1w/T2w ratio and cognition in 9-to-11-year-old children
AU - Langensee, Lara
AU - Rumetshofer, Theodor
AU - Behjat, Hamid
AU - Novén, Mikael
AU - Li, Ping
AU - Mårtensson, Johan
N1 - CURIS 2022 NEXS 129
PY - 2022
Y1 - 2022
N2 - Childhood is a period of extensive cortical and neural development. Among other things, axons in the brain gradually become more myelinated, promoting the propagation of electrical signals between different parts of the brain, which in turn may facilitate skill development. Myelin is difficult to assess in vivo, and measurement techniques are only just beginning to make their way into standard imaging protocols in human cognitive neuroscience. An approach that has been proposed as an indirect measure of cortical myelin is the T1w/T2w ratio, a contrast that is based on the intensities of two standard structural magnetic resonance images. Although not initially intended as such, researchers have recently started to use the T1w/T2w contrast for between-subjectcomparisons of cortical data with various behavioral and cognitive indices. As a complement to these earlier findings, we computed individual cortical T1w/T2w maps using data from the Adolescent Brain Cognitive Development study (N = 960; 449 females; aged 8.9 to 11.0 years) and related the T1w/T2w maps to indices of cognitive ability; in contrast to previous work, we did not findsignificant relationships between T1w/T2w values and cognitive performance after correcting for multiple testing. These findings reinforce existent skepticism about the applicability of T1w/T2w ratio for inter-individual comparisons.
AB - Childhood is a period of extensive cortical and neural development. Among other things, axons in the brain gradually become more myelinated, promoting the propagation of electrical signals between different parts of the brain, which in turn may facilitate skill development. Myelin is difficult to assess in vivo, and measurement techniques are only just beginning to make their way into standard imaging protocols in human cognitive neuroscience. An approach that has been proposed as an indirect measure of cortical myelin is the T1w/T2w ratio, a contrast that is based on the intensities of two standard structural magnetic resonance images. Although not initially intended as such, researchers have recently started to use the T1w/T2w contrast for between-subjectcomparisons of cortical data with various behavioral and cognitive indices. As a complement to these earlier findings, we computed individual cortical T1w/T2w maps using data from the Adolescent Brain Cognitive Development study (N = 960; 449 females; aged 8.9 to 11.0 years) and related the T1w/T2w maps to indices of cognitive ability; in contrast to previous work, we did not findsignificant relationships between T1w/T2w values and cognitive performance after correcting for multiple testing. These findings reinforce existent skepticism about the applicability of T1w/T2w ratio for inter-individual comparisons.
KW - Faculty of Science
KW - T1w/T2w ratio
KW - Structural MRI
KW - Intracortical myelin
KW - Cognitive abilities
KW - Neurocognition
U2 - 10.3390/brainsci12050599
DO - 10.3390/brainsci12050599
M3 - Journal article
C2 - 35624986
VL - 12
JO - Brain Sciences
JF - Brain Sciences
SN - 2076-3425
IS - 5
M1 - 599
ER -
ID: 305571342