The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

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Standard

The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. / la Cour, Jonas; Høj, Berit Rahbek; Mollerup, Jens; Simon, Ronald; Sauter, Guido; Berchtold, Martin Werner.

I: Molecular Oncology, Bind 1, Nr. 4, 2008, s. 431-439.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

la Cour, J, Høj, BR, Mollerup, J, Simon, R, Sauter, G & Berchtold, MW 2008, 'The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability', Molecular Oncology, bind 1, nr. 4, s. 431-439. https://doi.org/10.1016/j.molonc.2007.08.002

APA

la Cour, J., Høj, B. R., Mollerup, J., Simon, R., Sauter, G., & Berchtold, M. W. (2008). The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. Molecular Oncology, 1(4), 431-439. https://doi.org/10.1016/j.molonc.2007.08.002

Vancouver

la Cour J, Høj BR, Mollerup J, Simon R, Sauter G, Berchtold MW. The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. Molecular Oncology. 2008;1(4):431-439. https://doi.org/10.1016/j.molonc.2007.08.002

Author

la Cour, Jonas ; Høj, Berit Rahbek ; Mollerup, Jens ; Simon, Ronald ; Sauter, Guido ; Berchtold, Martin Werner. / The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. I: Molecular Oncology. 2008 ; Bind 1, Nr. 4. s. 431-439.

Bibtex

@article{907fdaf0dd8511ddb5fc000ea68e967b,
title = "The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability",
abstract = "The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.",
author = "{la Cour}, Jonas and H{\o}j, {Berit Rahbek} and Jens Mollerup and Ronald Simon and Guido Sauter and Berchtold, {Martin Werner}",
note = "Keywords: Calcium binding proteins, Tissue microarray, Gene silencing, ALG-2",
year = "2008",
doi = "10.1016/j.molonc.2007.08.002",
language = "English",
volume = "1",
pages = "431--439",
journal = "Molecular Oncology",
issn = "1574-7891",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

AU - la Cour, Jonas

AU - Høj, Berit Rahbek

AU - Mollerup, Jens

AU - Simon, Ronald

AU - Sauter, Guido

AU - Berchtold, Martin Werner

N1 - Keywords: Calcium binding proteins, Tissue microarray, Gene silencing, ALG-2

PY - 2008

Y1 - 2008

N2 - The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

AB - The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

U2 - 10.1016/j.molonc.2007.08.002

DO - 10.1016/j.molonc.2007.08.002

M3 - Journal article

C2 - 19383317

VL - 1

SP - 431

EP - 439

JO - Molecular Oncology

JF - Molecular Oncology

SN - 1574-7891

IS - 4

ER -

ID: 9590196