The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis

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Standard

The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis. / Rewitz, Kim F.; Yamanaka, Naoki; Gilbert, Lawrence I.; O'Connor, Michael B.

I: Science, Bind 326, Nr. 5958, 04.12.2009, s. 1403-1405.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rewitz, KF, Yamanaka, N, Gilbert, LI & O'Connor, MB 2009, 'The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis', Science, bind 326, nr. 5958, s. 1403-1405. https://doi.org/10.1126/science.1176450

APA

Rewitz, K. F., Yamanaka, N., Gilbert, L. I., & O'Connor, M. B. (2009). The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis. Science, 326(5958), 1403-1405. https://doi.org/10.1126/science.1176450

Vancouver

Rewitz KF, Yamanaka N, Gilbert LI, O'Connor MB. The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis. Science. 2009 dec. 4;326(5958):1403-1405. https://doi.org/10.1126/science.1176450

Author

Rewitz, Kim F. ; Yamanaka, Naoki ; Gilbert, Lawrence I. ; O'Connor, Michael B. / The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis. I: Science. 2009 ; Bind 326, Nr. 5958. s. 1403-1405.

Bibtex

@article{5ea6ae15037249d6980627c0f376ce9b,
title = "The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis",
abstract = "Holometabolous insects undergo complete metamorphosis to become sexually mature adults. Metamorphosis is initiated by brain-derived prothoracicotropic hormone ( PTTH), which stimulates the production of the molting hormone ecdysone via an incompletely defined signaling pathway. Here we demonstrate that Torso, a receptor tyrosine kinase that regulates embryonic terminal cell fate in Drosophila, is the PTTH receptor. Trunk, the embryonic Torso ligand, is related to PTTH, and ectopic expression of PTTH in the embryo partially rescues trunk mutants. In larvae, torso is expressed specifically in the prothoracic gland ( PG), and its loss phenocopies the removal of PTTH. The activation of Torso by PTTH stimulates extracellular signal-regulated kinase (ERK) phosphorylation, and the loss of ERK in the PG phenocopies the loss of PTTH and Torso. We conclude that PTTH initiates metamorphosis by activation of the Torso/ERK pathway.",
author = "Rewitz, {Kim F.} and Naoki Yamanaka and Gilbert, {Lawrence I.} and O'Connor, {Michael B.}",
year = "2009",
month = dec,
day = "4",
doi = "10.1126/science.1176450",
language = "English",
volume = "326",
pages = "1403--1405",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5958",

}

RIS

TY - JOUR

T1 - The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis

AU - Rewitz, Kim F.

AU - Yamanaka, Naoki

AU - Gilbert, Lawrence I.

AU - O'Connor, Michael B.

PY - 2009/12/4

Y1 - 2009/12/4

N2 - Holometabolous insects undergo complete metamorphosis to become sexually mature adults. Metamorphosis is initiated by brain-derived prothoracicotropic hormone ( PTTH), which stimulates the production of the molting hormone ecdysone via an incompletely defined signaling pathway. Here we demonstrate that Torso, a receptor tyrosine kinase that regulates embryonic terminal cell fate in Drosophila, is the PTTH receptor. Trunk, the embryonic Torso ligand, is related to PTTH, and ectopic expression of PTTH in the embryo partially rescues trunk mutants. In larvae, torso is expressed specifically in the prothoracic gland ( PG), and its loss phenocopies the removal of PTTH. The activation of Torso by PTTH stimulates extracellular signal-regulated kinase (ERK) phosphorylation, and the loss of ERK in the PG phenocopies the loss of PTTH and Torso. We conclude that PTTH initiates metamorphosis by activation of the Torso/ERK pathway.

AB - Holometabolous insects undergo complete metamorphosis to become sexually mature adults. Metamorphosis is initiated by brain-derived prothoracicotropic hormone ( PTTH), which stimulates the production of the molting hormone ecdysone via an incompletely defined signaling pathway. Here we demonstrate that Torso, a receptor tyrosine kinase that regulates embryonic terminal cell fate in Drosophila, is the PTTH receptor. Trunk, the embryonic Torso ligand, is related to PTTH, and ectopic expression of PTTH in the embryo partially rescues trunk mutants. In larvae, torso is expressed specifically in the prothoracic gland ( PG), and its loss phenocopies the removal of PTTH. The activation of Torso by PTTH stimulates extracellular signal-regulated kinase (ERK) phosphorylation, and the loss of ERK in the PG phenocopies the loss of PTTH and Torso. We conclude that PTTH initiates metamorphosis by activation of the Torso/ERK pathway.

U2 - 10.1126/science.1176450

DO - 10.1126/science.1176450

M3 - Journal article

VL - 326

SP - 1403

EP - 1405

JO - Science

JF - Science

SN - 0036-8075

IS - 5958

ER -

ID: 43935356