Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond. / Østergaard, Vibe Hallundbæk; Lisby, Michael.

I: Chromosoma, Bind 126, Nr. 2, 03.2017, s. 213-222.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Østergaard, VH & Lisby, M 2017, 'Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond', Chromosoma, bind 126, nr. 2, s. 213-222. https://doi.org/10.1007/s00412-016-0617-2

APA

Østergaard, V. H., & Lisby, M. (2017). Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond. Chromosoma, 126(2), 213-222. https://doi.org/10.1007/s00412-016-0617-2

Vancouver

Østergaard VH, Lisby M. Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond. Chromosoma. 2017 mar.;126(2):213-222. https://doi.org/10.1007/s00412-016-0617-2

Author

Østergaard, Vibe Hallundbæk ; Lisby, Michael. / Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond. I: Chromosoma. 2017 ; Bind 126, Nr. 2. s. 213-222.

Bibtex

@article{16481e5ea7e140989d8c3a2f747fe23e,
title = "Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond",
abstract = "Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.",
keywords = "Anaphase bridges, Chromosomal fragile sites, Mitosis, Replication, Template switching, Transcription",
author = "{\O}stergaard, {Vibe Hallundb{\ae}k} and Michael Lisby",
year = "2017",
month = mar,
doi = "10.1007/s00412-016-0617-2",
language = "English",
volume = "126",
pages = "213--222",
journal = "Chromosoma",
issn = "0009-5915",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond

AU - Østergaard, Vibe Hallundbæk

AU - Lisby, Michael

PY - 2017/3

Y1 - 2017/3

N2 - Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.

AB - Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.

KW - Anaphase bridges

KW - Chromosomal fragile sites

KW - Mitosis

KW - Replication

KW - Template switching

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=84992740339&partnerID=8YFLogxK

U2 - 10.1007/s00412-016-0617-2

DO - 10.1007/s00412-016-0617-2

M3 - Review

C2 - 27796495

AN - SCOPUS:84992740339

VL - 126

SP - 213

EP - 222

JO - Chromosoma

JF - Chromosoma

SN - 0009-5915

IS - 2

ER -

ID: 174176586