Ubiquitin domain proteins in disease
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Ubiquitin domain proteins in disease. / Klausen, Louise Kjær; Schulze, Andrea; Seeger, Michael; Hartmann-Petersen, Rasmus.
I: Biochemistry, Bind 8, Nr. 1, 2007, s. 1.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ubiquitin domain proteins in disease
AU - Klausen, Louise Kjær
AU - Schulze, Andrea
AU - Seeger, Michael
AU - Hartmann-Petersen, Rasmus
N1 - Keywords: Animals; Disease Models, Animal; Gene Targeting; Humans; Nervous System Diseases; Protein Structure, Tertiary; Ubiquitin
PY - 2007
Y1 - 2007
N2 - The human genome encodes several ubiquitin-like (UBL) domain proteins (UDPs). Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome system, an essential pathway for protein degradation in eukaryotic cells. Despite their structural similarity, the UBL domains appear to have a range of different targets, resulting in a considerable diversity with respect to UDP function. Here, we give a short summary of the biochemical and physiological roles of the UDPs, which have been linked to human diseases including neurodegeneration and cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
AB - The human genome encodes several ubiquitin-like (UBL) domain proteins (UDPs). Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome system, an essential pathway for protein degradation in eukaryotic cells. Despite their structural similarity, the UBL domains appear to have a range of different targets, resulting in a considerable diversity with respect to UDP function. Here, we give a short summary of the biochemical and physiological roles of the UDPs, which have been linked to human diseases including neurodegeneration and cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
U2 - 10.1186/1471-2091-8-S1-S1
DO - 10.1186/1471-2091-8-S1-S1
M3 - Journal article
C2 - 18047733
VL - 8
SP - 1
JO - Biochemistry
JF - Biochemistry
SN - 0006-2960
IS - 1
ER -
ID: 9089043