Unravelling animal–microbiota evolution on a chip
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Whether and how microorganisms have shaped the evolution of their animal hosts is a major question in biology. Although many animal evolutionary processes appear to correlate with changes in their associated microbial communities, the mechanistic processes leading to these patterns and their causal relationships are still far from being resolved. Gut-on-a-chip models provide an innovative approach that expands beyond the potential of conventional microbiome profiling to study how different animals sense and react to microbes by comparing responses of animal intestinal tissue models to different microbial stimuli. This complementary knowledge can contribute to our understanding of how host genetic features facilitate or prevent different microbiomes from being assembled, and in doing so elucidate the role of host–microbiota interactions in animal evolution.
Originalsprog | Engelsk |
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Tidsskrift | Trends in Microbiology |
Vol/bind | 31 |
Udgave nummer | 10 |
Sider (fra-til) | 995-1002 |
Antal sider | 8 |
ISSN | 0966-842X |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The authors thank the Danish National Research Foundation award DNRF143 ‘A Center for Evolutionary Hologenomics’ for funding their research. O.A. acknowledges Villum Foundation's grant 50283. A.A. acknowledges Novo Nordisk Foundation's grant 0071513. Some of the elements in the figures have been obtained and modified from the Integration and Application Network, University of Maryland Center for Environmental Science (http://ian.umces.edu/media-library). No interests are declared.
Publisher Copyright:
© 2023 Elsevier Ltd
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