Stine Helene Falsig Pedersen
Professor
Cell Biology and Physiology
Universitetsparken 13
2100 København Ø
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Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison
Panou, D. A., Pedersen, Stine Helene Falsig, Kristensen, Mie & Nielsen, Hanne Mørck, 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.Research output: Contribution to journal › Journal article › Research › peer-review
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Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer
Pedersen, A., Mendes Lopes de Melo, J., Mørup, N., Tritsaris, Katerina & Pedersen, Stine Helene Falsig, 2017, In: BMC Cancer. 17, 15 p., 542.Research output: Contribution to journal › Journal article › Research › peer-review
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Glycosylation of solute carriers: mechanisms and functional consequences
Pedersen, N. B., Carlsson, M. C. & Pedersen, Stine Helene Falsig, 2016, In: Pflügers Archiv - European Journal of Physiology. 468, 2, p. 159-176 18 p.Research output: Contribution to journal › Review › Research › peer-review
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The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology
Pedersen, Stine Helene Falsig & Counillon, L., 2019, In: Physiological Reviews. 99, 4, p. 2015-2113 99 p.Research output: Contribution to journal › Review › Research › peer-review
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Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain, and blood
Pedersen, Stine Helene Falsig, O´Donnell, M. E., Anderson, S. E. & Cala, P. M., 2006, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 291, 1, p. R1-R25Research output: Contribution to journal › Journal article › Research › peer-review
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Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts.
Pedersen, Stine Helene Falsig, Beisner, K. H., Willumsen, Berthe Marie, Lambert, Ian Henry & Hoffmann, E. K., 2002, In: Journal of Physiology. 541, Pt 3, p. 779-96 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.
Pedersen, Stine Helene Falsig, King, S. A., Nygaard, E. B., Rigor, R. R. & Cala, P. M., 2007, In: Journal of Biological Chemistry. 282, 27, p. 19716-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A.
Pedersen, Stine Helene Falsig, King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M. & Cala, P. M., 2003, In: American Journal of Physiology.. Vol. 284 (6), p. C1561-C1576Research output: Contribution to journal › Journal article › Research › peer-review
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The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer
Pedersen, Stine Helene Falsig, Flinck, M. & Pardo, L. A., 2021, In: International Journal of Molecular Sciences. 22, 10, 27 p., 5209.Research output: Contribution to journal › Review › Research › peer-review
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Mechanisms of pHi regulation studied in individual neurons cultured from mouse cerebral cortex
Pedersen, Stine Helene Falsig, Jørgensen, N. K., Damgaard, I., Schousboe, A. & Hoffmann, E. K., 1998, In: Journal of Neuroscience Research. 51, p. 431-441Research output: Contribution to journal › Journal article › Research › peer-review
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Role of the F-actin cytoskeleton in the RVD and RVI processes in Ehrlich ascites tumor cells.
Pedersen, Stine Helene Falsig, Mills, J. W. & Hoffmann, E. K., 1999, In: Experimental Cell Research. 252, p. 63-74Research output: Contribution to journal › Journal article › Research › peer-review
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Separate swelling- og Ca2+-activated anion currents in Ehrlich ascites tumor cells
Pedersen, Stine Helene Falsig, Prenen, J., Droogmans, G., Hoffmann, E. K. & Nilius, B., 1998, In: J. Membrane Biol.. 163, p. 97-110Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A
Pedersen, Stine Helene Falsig, King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M. & Cala, P. M., 2003, In: FASEB Journal. Vol. 19 (4), p. A 139- A 140Research output: Contribution to journal › Journal article › Research › peer-review
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The Na+/H+ Exchange system in Ehrlich ascites tumour cells. Effects of cell volume, phosphorylation and calcium.
Pedersen, Stine Helene Falsig, Kramhøft, B., Jørgensen, N. K. & Hoffmann, E. K., 1994, In: Acta Physiologica (Print Edition). 151(4), p. 26AResearch output: Contribution to journal › Journal article › Research › peer-review
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The cytoskeleton and cell volume regulation
Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Mills, J. W., 2001, In: Comparative Biochemistry and Physiology Part A. 130, p. 385-399Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamics of Ca2+i and pHi in Ehrlich ascites tumor cells after Ca2+-mobilizing agonists or exposure to hypertonic solution
Pedersen, Stine Helene Falsig, Jørgensen, N. K. & Hoffmann, E. K., 1998, In: Pflügers Archiv: European Journal of Physiology. 436, 2, p. 199-210Research output: Contribution to journal › Journal article › Research › peer-review
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Signal transduction mechanisms involved in the rgulation of NHE1 from Pseudopleuronectes Americanus red blood cells by osmotic shrinkage , ß-adrenergic stimuli, and calyculin A
Pedersen, Stine Helene Falsig, Holt, M., King, S. A. & Cala, P. M., 2004, In: Bull. Mount Desert Island Biol. Lab. 43, p. 9-11Research output: Contribution to journal › Journal article › Research › peer-review
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Possible Interrelationship between Changes in F-actin and Myosin II, Protein Phosphorylation and Cell Volume Regulation in Ehrlich Ascites Tumor Cells
Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2002, In: Experimental Cell Research. 277, p. 57-73Research output: Contribution to journal › Journal article › Research › peer-review
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P2 receptor-mediated signal transduction in Ehrlich ascites tumor cells
Pedersen, Stine Helene Falsig, Pedersen, S., Lambert, Ian Henry & Hoffmann, E. K., 1998, In: BBA General Subjects. 1374, p. 94-106Research output: Contribution to journal › Journal article › Research › peer-review
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Hsp-70 mediated protection of WEHI cells against hypertonic stress-induced programmed cell death by a mechanism independent of effects on volume-regulatory membrane transport proteins
Pedersen, Stine Helene Falsig, Larsen, J. N., Hoffmann, E. K. & Jaattela, M., 2004, In: The FASEB Journal. 18 (5), p. A1284 suppl.s.Research output: Contribution to journal › Journal article › Research › peer-review
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Transient receptor potential channels in mechanosensing and cell volume regulation.
Pedersen, Stine Helene Falsig & Nilius, B., 2007, In: Methods in Enzymology. 428, p. 183-207 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1: lessons from erythrocytes.
Pedersen, Stine Helene Falsig & Cala, P. M., 2004, In: Journal of experimental zoology. Part A, Comparative experimental biology. 301, 7, p. 569-78 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel NHE1 from red blood cells of the winter flounder: regulation by multiple signaling pathways.
Pedersen, Stine Helene Falsig, 2004, In: Advances in Experimental Medicine and Biology. 559, p. 89-98 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TRP channels: an overview.
Pedersen, Stine Helene Falsig, Owsianik, G. & Nilius, B., 2005, In: Cell Calcium. 38, 3-4, p. 233-52 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death.
Pedersen, Stine Helene Falsig, 2006, In: Pflügers Archiv: European Journal of Physiology. 452, 3, p. 249-59 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acid–base transporters in the context of tumor heterogeneity
Pedersen, Stine Helene Falsig, 2024, In: Pflugers Archiv European Journal of Physiology. 476, p. 689–701 13 p.Research output: Contribution to journal › Review › Research › peer-review
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Ion channels and transporters in cancer: pathophysiology, regulation, and clinical potential
Pedersen, Stine Helene Falsig & Stock, C., 2013, In: Cancer Research. 73, 6, p. 1658-1661 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biophysics and physiology of the volume-regulated anion channel (VRAC)/volume-sensitive outwardly rectifying anion channel (VSOR)
Pedersen, Stine Helene Falsig, Okada, Y. & Nilius, B., 2016, In: Pflügers Archiv - European Journal of Physiology. 468, 3, p. 371-383 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts.
Pedersen, Stine Helene Falsig, Poulsen, K. A. & Lambert, Ian Henry, 2006, In: American Journal of Physiology: Cell Physiology. 291, 6, p. C 1286-1296Research output: Contribution to journal › Journal article › Research › peer-review
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Osmosensory mechanisms in cellular and systemic volume regulation
Pedersen, Stine Helene Falsig, Kapus, A. & Hoffmann, E. K., 2011, In: Journal of the American Society of Nephrology. 22, 9, p. 1587-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell volume regulation in epithelial physiology and cancer
Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Novak, Ivana, 2013, In: Frontiers in Physiology. 4, 12 p., 233.Research output: Contribution to journal › Review › Research › peer-review
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Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1.
Pedersen, Stine Helene Falsig, Darborg, B. V., Rentsch, M. L. & Rasmussen, M., 2006, In: Archives of Biochemistry and Biophysics. 462, 2, p. 195-201 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The identification of a volume-regulated anion channel: an amazing Odyssey
Pedersen, Stine Helene Falsig, Klausen, T. K. & Nilius, B., 2015, In: Acta Physiologica (Print). 213, 4, p. 868-881 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells.
Pedersen, Stine Helene Falsig, Varming, C., Christensen, Søren Tvorup & Hoffmann, E. K., 2002, In: Journal of Membrane Biology. 189, 1, p. 67-81 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alternating pH landscapes shape epithelial cancer initiation and progression: focus on pancreatic cancer
Pedersen, Stine Helene Falsig, Novak, Ivana, Alves, F., Schwab, A. & Pardo, L. A., Jun 2017, In: BioEssays. 39, 6, 10 p., 1600253.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanical stress induces release of ATP from Ehrlich ascites tumor cells.
Pedersen, S., Pedersen, Stine Helene Falsig, Nilius, B., Lambert, Ian Henry & Hoffmann, E. K., 1999, In: BBA General Subjects. 1416, p. 271-284Research output: Contribution to journal › Journal article › Research › peer-review
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Prolactin signaling stimulates invasion via Na+/H+ exchanger NHE1 in T47D human breast cancer cells
Pedraz Cuesta, E., Fredsted, J., Jensen, H. H., Bornebusch, A., Nejsum, L. N., Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2016, In: Molecular Endocrinology. 30, 7, p. 693-708 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism
Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, Marie Sophie, Markussen, L. K., Viuff, B. M., Lambert, Ian Henry, Hansen, Jacob B. & Pedersen, Stine Helene Falsig, 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.Research output: Contribution to journal › Journal article › Research › peer-review
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The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells.
Pedersen, Stine Helene Falsig, Rasmussen, M., Darborg, B. V., Nylandsted, J. & Hoffmann, E. K., 2007, In: Cellular Physiology and Biochemistry. 20, 6, p. 735-50 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Snowpack fluxes of methane and carbon dioxide from high Arctic tundra
Pirk, N., Tamstorf, M. P., Lund, M., Mastepanov, M., Pedersen, Stine Helene Falsig, Mylius, M. R., Parmentier, F. W., Christiansen, H. H. & Christensen, T. R., 2016, In: Journal of Geophysical Research: Biogeosciences. 121, 11, p. 2886-2900 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.
Poulsen, K. A., Pedersen, Stine Helene Falsig, Kolko, M. & Lambert, Ian Henry, 2007, In: American Journal of Physiology: Cell Physiology. 293, 5, p. C1605-15Research output: Contribution to journal › Journal article › Research › peer-review
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Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells
Rasmussen, L. J. H., Mûller, H. S. H., Jørgensen, B., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2015, In: American Journal of Physiology: Cell Physiology. 308, 2, p. C101-C110 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications
Rasmussen, M., Alexander, R. T., Darborg, B. V., Møbjerg, Nadja, Hoffmann, E. K., Kapus , A. & Pedersen, Stine Helene Falsig, 2008, In: American Journal of Physiology: Cell Physiology. 294, 1, p. C197-C212 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of chemical anoxia on NHE1, p38 MAPK, p53, Akt and ERM proteins in NIH3T3 fibroblasts: evidence for a role of NHE1 upstream of p38 MAPK
Rentsch, M. L., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2006, In: The FASEB Journal. 5, p. A1158Research output: Contribution to journal › Conference abstract in journal › Research
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Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts.
Rentsch, M. L., Ossum, C. G., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2007, In: Pflügers Archiv: European Journal of Physiology. 454, 4, p. 649-62 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chronic acidosis rewires cancer cell metabolism through PPARα signaling
Rolver, M. G., Holland, L. K. K., Ponniah, M., Prasad, N. S., Yao, Jiayi, Schnipper, J., Kramer, S., Elingaard-Larsen, L., Pedraz-Cuesta, E., Liu, B., Pardo, L. A., Maeda, K., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2023, In: International Journal of Cancer. 152, 8, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells
Rolver, M. G., Elingaard-Larsen, L. O. & Pedersen, Stine Helene Falsig, 2019, In: Journal of Visualized Experiments. 2019, 148, e59714.Research output: Contribution to journal › Journal article › Research › peer-review
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Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1
Rolver, M. G., Elingaard-Larsen, L. O., Andersen, Anne Poder, Counillon, L. & Pedersen, Stine Helene Falsig, 2020, In: Scientific Reports. 10, 17 p., 5800.Research output: Contribution to journal › Journal article › Research › peer-review
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Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer
Rolver, M. G. & Pedersen, Stine Helene Falsig, 2021, In: British Journal of Cancer. 124, p. 1-2 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Myocardin-related transcription factor regulates Nox4 protein expression: linking cytoskeletal orginization to redox state
Rozycki, M., Bialik, J. F., Speight, P., Dan, Q., Knudsen, Teresa Emmilie Toudal, Szeto, S. G., Yuen, D. A., Szászi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2016, In: Journal of Biological Chemistry. 291, 1, p. 227-243 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8742
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3549
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Annual Meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer
Research output: Contribution to journal › Comment/debate › Research
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2071
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Cell volume regulation in epithelial physiology and cancer
Research output: Contribution to journal › Review › Research › peer-review
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1876
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
Research output: Contribution to journal › Journal article › Research › peer-review
Published