Stine Helene Falsig Pedersen
Professor
Cell Biology and Physiology
Universitetsparken 13
2100 København Ø
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Glycosylation of solute carriers: mechanisms and functional consequences
Pedersen, N. B., Carlsson, M. C. & Pedersen, Stine Helene Falsig, 2016, In: Pflügers Archiv - European Journal of Physiology. 468, 2, p. 159-176 18 p.Research output: Contribution to journal › Review › Research › peer-review
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Gram-scale solution-phase synthesis of selective sodium bicarbonate Co-transport Inhibitor S0859: in vitro efficacy studies in breast cancer cells
Larsen, A. M., Krogsgaard-Larsen, N., Lauritzen, G., Olesen, C. W., Hansen, S. H., Bødtkjer, E., Pedersen, Stine Helene Falsig & Bunch, Lennart, 2012, In: ChemMedChem. 7, 10, p. 1808-1814 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts.
Schneider, L., Klausen, T. K., Stock, C., Mally, S., Christensen, Søren Tvorup, Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Schwab, A., 2008, In: Pflügers Archiv: European Journal of Physiology. 455, 6, p. 1055-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503
Gorbatenko, A., Søkilde, R., Sorensen, E. E., Newie, I., Persson, H., Morancho, B., Arribas, J., Litman, Thomas, Rovira, C. & Pedersen, Stine Helene Falsig, 2019, In: Scientific Reports. 9, 1, p. 1-16 3352.Research output: Contribution to journal › Journal article › Research › peer-review
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HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange
Andersen, A., Poulsen, K. A., Lambert, Ian Henry & Pedersen, Stine Helene Falsig, 2009, In: American Journal of Physiology: Cell Physiology. 296, 5, p. C1227-42Research output: Contribution to journal › Journal article › Research › peer-review
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Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins.
Nylandsted, J., Jäättelä, M., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2004, In: Pflügers Archiv: European Journal of Physiology. 449, 2, p. 175-85 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression
Elingaard-Larsen, L. O., Rolver, M. G., Sørensen, E. E. & Pedersen, Stine Helene Falsig, 2022, From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. Stock, C. & Pardo, L. A. (eds.). Springer, p. 1-38 38 p. (Reviews of Physiology, Biochemistry and Pharmacology, Vol. 182).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
How protons pave the way to aggressive cancers
Swietach, P., Boedtkjer, E. & Pedersen, Stine Helene Falsig, 2023, In: Nature Reviews Cancer. 23, p. 825-841 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Hsp-70 mediated protection of WEHI cells against hypertonic stress-induced programmed cell death by a mechanism independent of effects on volume-regulatory membrane transport proteins
Pedersen, Stine Helene Falsig, Larsen, J. N., Hoffmann, E. K. & Jaattela, M., 2004, In: The FASEB Journal. 18 (5), p. A1284 suppl.s.Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response
Thirone, A. C. P., Speight, P., Zulys, M., Rotstein, O. D., Szaszi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2009, In: American Journal of Physiology: Cell Physiology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton
Ly, D. L., Waheed, F., Lodyga, M., Speight, P., Masszi, A., Nakano, H., Hersom, M. N. S., Pedersen, Stine Helene Falsig, Szászi, K. & Kapus, A., 2013, In: American Journal of Physiology: Cell Physiology. 304, 2, p. C115-C127 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in ehrlich lettré ascites cells through a mechanism involving p38 mitogen-activated protein kinase
Gorbatenko, A., Wiwel, M., Klingberg, H., Nielsen, A. B., Kapus, A. & Pedersen, Stine Helene Falsig, 2011, In: Journal of Cellular Physiology. 226, 11, p. 2857-2868 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increases in [Ca2+]i and changes in intracellular pH during chemical anoxia in mouse neocortical neurons in primary culture.
Jørgensen, N. K., Pedersen, Stine Helene Falsig, Damgaard, I., Schousboe, A. & Hoffmann, E. K., 1999, In: Journal of Neuroscience Research. 56, p. 358-370Research output: Contribution to journal › Journal article › Research › peer-review
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Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.
Poulsen, K. A., Pedersen, Stine Helene Falsig, Kolko, M. & Lambert, Ian Henry, 2007, In: American Journal of Physiology: Cell Physiology. 293, 5, p. C1605-15Research output: Contribution to journal › Journal article › Research › peer-review
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Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment
Andersen, Anne Poder, Moreira, José & Pedersen, Stine Helene Falsig, 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1638, 11 p., 20130098.Research output: Contribution to journal › Journal article › Research › peer-review
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Intracellular pH gradients in migrating cells
Martin, C., Pedersen, Stine Helene Falsig, Schwab, A. & Stock, C., 2011, In: American Journal of Physiology: Cell Physiology. 300, 3, p. C490-C495 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes
Haxholm, G. W., Nikolajsen, L. F., Olsen, Johan Gotthardt, Fredsted, J., Larsen, F. H., Goffin, V., Pedersen, Stine Helene Falsig, Brooks, A. J., Waters, M. J. & Kragelund, Birthe Brandt, 2015, In: Biochemical Journal. 468, 3, p. 495-506 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
Veland, I. R., Montjean, R., Eley, L., Pedersen, Lotte Bang, Schwab, A., Goodship, J., Kristiansen, Karsten, Pedersen, Stine Helene Falsig, Saunier, S. & Christensen, Søren Tvorup, 2013, In: P L o S One. 8, 4, 15 p., e60193.Research output: Contribution to journal › Journal article › Research › peer-review
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Ion channels and transporters in cancer: pathophysiology, regulation, and clinical potential
Pedersen, Stine Helene Falsig & Stock, C., 2013, In: Cancer Research. 73, 6, p. 1658-1661 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ion transport proteins control pancreatic cancer cell behaviour
Schwab, A., Stock, C., Swietach, P., Hulikova, A., Vaughan-Jones, R. D., Pedersen, S. H. F., Andersen, A-D., Hoffmann, E. K., Novak, I., Reshkin, S., Prevarskaya, N., Lemonnier, L., Borowiec, A. S., Arcangeli, A., Zanieri, F., D´Amico, M., Fraser, S. P., Djamgoz, M. BA., Alves, F., Kalthoff, H. & 2 others, , 2010, In: Acta Physiologica (Print Edition). 198, 677, p. 17 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Ion transport proteins control pancreatic ductal adenocarcinoma
Schwab, A., Stock, C., Swietach, P., Hulikova, A., Vaughan-Jones, R., Pedersen, S. H. F., Andersen, A. D., Hoffmann, E., Novak, I., Reshkin, S., Prevarskaya, N., Lemonnier, L., A-S, B., Fraser, S. P., Arcangeli, A., Zanieri, F., D'Amico, M., Kalthoff, H., Djamgoz, M. B., Alves, F. & 2 others, , 1 Oct 2010, In: Onkologie. 33, Suppl. 6, p. 269 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
Jørgensen, Kathrine Lundø, Dmytriyeva, O., Spøhr, L., Alves, Eliana Carolina Goncalves, Yao, Jiayi, Puig Blasco, Laia, Trauelsen, Mette, Ponniah, M., Severin, M., Sandelin, Albin Gustav, Kveiborg, Marie, Schwartz, Thue W. & Pedersen, Stine Helene Falsig, 2023, In: BMC Cancer. 23, 1, 20 p., 1136.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair
Schreml, S., Meier, R. J., Kirschbaum, M., Kong, S. C., Gehmert, S., Felthaus, O., Kuechler, S., Sharpe, J. R., Woeltje, K., Weiss, K. T., Albert, M., Seidl, U., Schroeder, J., Morsczeck, C., Prantl, L., Duschl, C., Pedersen, S. H. F., Gosau, M., Berneburg, M., Wolfbeis, O. S. & 2 others, , 2014, In: Theranostics. 4, 7, p. 721-735 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism
Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, Marie Sophie, Markussen, L. K., Viuff, B. M., Lambert, Ian Henry, Hansen, Jacob B. & Pedersen, Stine Helene Falsig, 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.Research output: Contribution to journal › Journal article › Research › peer-review
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MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells
Meng, Signe, Sørensen, E. E., Ponniah, M., Thorlacius-Ussing, J., Crouigneau, R., Larsen, T., Borre, M. T., Willumsen, N., Flinck, M. & Pedersen, Stine Helene Falsig, 2024, In: Journal of Cell Science. 137, 8, 15 p., jcs261608.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanical stress induces release of ATP from Ehrlich ascites tumor cells.
Pedersen, S., Pedersen, Stine Helene Falsig, Nilius, B., Lambert, Ian Henry & Hoffmann, E. K., 1999, In: BBA General Subjects. 1416, p. 271-284Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells.
Pedersen, Stine Helene Falsig, Varming, C., Christensen, Søren Tvorup & Hoffmann, E. K., 2002, In: Journal of Membrane Biology. 189, 1, p. 67-81 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of pHi regulation studied in individual neurons cultured from mouse cerebral cortex
Pedersen, Stine Helene Falsig, Jørgensen, N. K., Damgaard, I., Schousboe, A. & Hoffmann, E. K., 1998, In: Journal of Neuroscience Research. 51, p. 431-441Research output: Contribution to journal › Journal article › Research › peer-review
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Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets
Andersen, Henriette Berg, Ialchina, Renata, Pedersen, Stine Helene Falsig & Czaplinska, D., 2021, In: Cancer and Metastasis Reviews. 40, 4, p. 1093-1114 22 p.Research output: Contribution to journal › Review › Research › peer-review
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Metabolism and microenvironment in cancer plasticity
Baldini, N., Sonveaux, P., De Milito, A., Supuran, C. T., Otto, A. M., Stock, C. M., Pedersen, Stine Helene Falsig, Favicchio, R. & Avnet, S., 2016, In: Cancer & Metabolism. 4, Supplement 1, 7 p., 1.Research output: Contribution to journal › Comment/debate › Research
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Modeling the ischemic blood-brain barrier; the effects of oxygen-glucose deprivation (OGD) on endothelial cells in culture
Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 19 Jun 2016.Research output: Contribution to conference › Conference abstract for conference › Communication
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Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study
Klausen, T. K., Pagani, A., Minassi, A., Ech-Chahad, A., Prenen, J., Owsianik, G., Hoffmann, E. K., Pedersen, Stine Helene Falsig, Appendino, G. & Nilius, B., 2009, In: Journal of Medicinal Chemistry. 52, 9, p. 2933-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, Lise Margrethe, Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, Birthe Brandt, Pedersen, Stine Helene Falsig & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A
Pedersen, Stine Helene Falsig, King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M. & Cala, P. M., 2003, In: FASEB Journal. Vol. 19 (4), p. A 139- A 140Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A.
Pedersen, Stine Helene Falsig, King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M. & Cala, P. M., 2003, In: American Journal of Physiology.. Vol. 284 (6), p. C1561-C1576Research output: Contribution to journal › Journal article › Research › peer-review
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Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of pancreatic ductal adenocarcinoma cells
Kong, S. C., Nøhr-Nielsen, A., Zeeberg, K., Reshkin, S. J., Hoffmann, E. K., Novak, Ivana & Pedersen, Stine Helene Falsig, 2016, In: Pancreas. 45, 7, p. 1036-1047 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Monovalent ions control proliferation of Ehrlich Lettre ascites cells
Klausen, T. K., Preisler, S., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 1 Sep 2010, In: American Journal of Physiology (Consolidated). 299, 3, p. C714-25Research output: Contribution to journal › Journal article › Research › peer-review
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Multiple PLA2 isoforms regulate taurine release in NIH3T3 mouse fibroblasts.
Lambert, Ian Henry & Pedersen, Stine Helene Falsig, 2006, In: Advances in Experimental Medicine and Biology. 583, p. 99-108 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Myocardin-related transcription factor regulates Nox4 protein expression: linking cytoskeletal orginization to redox state
Rozycki, M., Bialik, J. F., Speight, P., Dan, Q., Knudsen, Teresa Emmilie Toudal, Szeto, S. G., Yuen, D. A., Szászi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2016, In: Journal of Biological Chemistry. 291, 1, p. 227-243 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance
Lauritzen, G., Jensen, M. B. F., Bødtkjer, E., Dybboe, R., Aalkjær, Christian, Nylandsted, J. & Pedersen, Stine Helene Falsig, 10 Sep 2010, In: Experimental Cell Research. 316, 15, p. 2538-53 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.
Pedersen, Stine Helene Falsig, King, S. A., Nygaard, E. B., Rigor, R. R. & Cala, P. M., 2007, In: Journal of Biological Chemistry. 282, 27, p. 19716-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Na+,HCO3--cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice
Lee, S., Axelsen, T. V., Jesse, N., Pedersen, Stine Helene Falsig, Vahl, P. & Boedtkjer, E., 2018, In: Oncogene. 37, 41, p. 5569-5584Research output: Contribution to journal › Journal article › Research › peer-review
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O-glycan initiation directs distinct biological pathways and controls epithelial differentiation
Bagdonaite, Ieva , Pallesen, E. M. H., Ye, Z., Vakhrushev, Sergey, Marinova, I. N., Nielsen, Mathias Alexander Ingemann, Kramer, S. H., Pedersen, Stine Helene Falsig, Joshi, Hiren Jitendra, Bennett, Eric Paul, Dabelsteen, Sally & Wandall, Hans H., 2020, In: EMBO Reports. 21, 6, 17 p., e48885.Research output: Contribution to journal › Journal article › Research › peer-review
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On the role of TRPC1 in control of Ca2+ influx, cell volume, and cell cycle
Madsen, C. P., Klausen, T. K., Fabian, A., Hansen, B. J., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2012, In: American Journal of Physiology: Cell Physiology. 303, 6, p. C625-C634 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes
Gorbatenko, A., Olesen, C. W., Loebl, N., Sigurdsson, H. H., Bianchi, C., Pedraz Cuesta, E., Christiansen, Jan & Pedersen, Stine Helene Falsig, 2016, In: Biochemical Journal. 473, 21, p. 4027-4044 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Osmosensory mechanisms in cellular and systemic volume regulation
Pedersen, Stine Helene Falsig, Kapus, A. & Hoffmann, E. K., 2011, In: Journal of the American Society of Nephrology. 22, 9, p. 1587-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications
Rasmussen, M., Alexander, R. T., Darborg, B. V., Møbjerg, Nadja, Hoffmann, E. K., Kapus , A. & Pedersen, Stine Helene Falsig, 2008, In: American Journal of Physiology: Cell Physiology. 294, 1, p. C197-C212 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells
Rasmussen, L. J. H., Mûller, H. S. H., Jørgensen, B., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2015, In: American Journal of Physiology: Cell Physiology. 308, 2, p. C101-C110 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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P2 receptor-mediated signal transduction in Ehrlich ascites tumor cells
Pedersen, Stine Helene Falsig, Pedersen, S., Lambert, Ian Henry & Hoffmann, E. K., 1998, In: BBA General Subjects. 1374, p. 94-106Research output: Contribution to journal › Journal article › Research › peer-review
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PDGFR alpha signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90(RSK) and AKT signaling pathways
Clement, Ditte Lynge, Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen, Stine Helene Falsig & Christensen, Søren Tvorup, 2013, In: Journal of Cell Science. 126, 4, p. 953-965 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8742
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3550
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Annual Meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer
Research output: Contribution to journal › Comment/debate › Research
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2075
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Cell volume regulation in epithelial physiology and cancer
Research output: Contribution to journal › Review › Research › peer-review
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1877
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
Research output: Contribution to journal › Journal article › Research › peer-review
Published