Stine Helene Falsig Pedersen

Stine Helene Falsig Pedersen

Professor

ORCID: 0000-0002-3044-7714

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  1. Published

    pH regulation in sensitive and multidrug resistant Ehrlich ascites tumor cells

    Litman, Thomas, Pedersen, Stine Helene Falsig, Kramhøft, B., Skovsgaard, T. & Hoffmann, E. K., 1998, In: Cell. Physiol. Biochem.. 8, p. 138-150

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Yeast recombinant production of intact human membrane proteins with long intrinsically disordered intracellular regions for structural studies

    Kassem, N., Kassem, M. M., Pedersen, Stine Helene Falsig, Pedersen, Per Amstrup & Kragelund, Birthe Brandt, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 14 p., 183272.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Why Warburg Works: Lactate Controls Immune Evasion through GPR81

    Jørgensen, Kathrine Lundø, Trauelsen, Mette, Pedersen, Stine Helene Falsig & Schwartz, Thue W., 2020, In: Cell Metabolism. 31, 4, p. 666–668 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  4. Published

    Two distinct domains involved in amiloride inhibition of the Na+/H+Exchanger, NHE1.

    King, S. A., Pedersen, Stine Helene Falsig & Cala, P. M., 2005, In: FASEB Journal. Vol. 19 (5), p. A1585

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer

    Pedersen, A., Mendes Lopes de Melo, J., Mørup, N., Tritsaris, Katerina & Pedersen, Stine Helene Falsig, 2017, In: BMC Cancer. 17, 15 p., 542.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Transmembrane transporter proteins: Capturing transport in motion

    Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  7. Published

    Transient receptor potential channels in mechanosensing and cell volume regulation.

    Pedersen, Stine Helene Falsig & Nilius, B., 2007, In: Methods in Enzymology. 428, p. 183-207 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Trafficking, localization and degradation of the Na+,HCO3- Co-transporter NBCn1 in kidney and breast epithelial cells

    Olesen, C. W., Vogensen, J., Axholm, I., Severin, M., Schnipper, J., Pedersen, I. S., von Stemann, J. H., Schrøder, J. M., Christensen, D. P. & Pedersen, Stine Helene Falsig, 2018, In: Scientific Reports. 8, p. 1-16 7435.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Thrombin-, bradykinin-, and arachidonic acid-induced Ca2+ signaling in Ehrlich ascites tumor cells.

    Jørgensen, N. K., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 1999, In: Am. J. Physiol.. 276, p. C26-C37

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4

    Thiesen, L., Belew, Zeinu Mussa, Griem-Krey, Nane, Pedersen, Stine Helene Falsig, Crocoll, C., Nour-Eldin, Hussam Hassan & Wellendorph, Petrine, 15 Feb 2020, In: European Journal of Pharmaceutical Sciences. 143, p. 1-9 105203.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

    Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms

    Andersen, Anne Poder, Samsøe-Petersen, Jacob, Ørnbo, E. K., Bødtkjer, E., Moreira, José, Kveiborg, Marie & Pedersen, Stine Helene Falsig, 2018, In: International Journal of Cancer. 142, 12, p. 2529-2542 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity

    Hendus-Altenburger, R., Vogensen, J., Pedersen, E. S., Luchini, A., Araya-Secchi, R., Bendsoe, A. H., Prasad, N. S., Prestel, Andreas, Cardenas, M., Pedraz-Cuesta, E., Arleth, Lise, Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 3 Dec 2020, In: Communications Biology . 3, 1, 18 p., 731.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The in vitro blood-brain barrier model under OGD condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  15. Published

    The identification of a volume-regulated anion channel: an amazing Odyssey

    Pedersen, Stine Helene Falsig, Klausen, T. K. & Nilius, B., 2015, In: Acta Physiologica (Print). 213, 4, p. 868-881 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

    Hendus-Altenburger, R., Pedraz Cuesta, E., Olesen, C. W., Papaleo, E., Schnell, J. A., Hopper, J. T. S., Robinson, C. V., Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 2016, In: BMC Biology. 14, 17 p., 31.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

    Cuesta, E. P., Christensen, S., Jensen, Anders A., Jensen, N. F., Bunch, Lennart, Rømer, M. U. K., Brünner, N., Stenvang, Jan & Pedersen, Stine Helene Falsig, 2015, In: B M C Cancer. 15, 1, 17 p., 411.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    The cytoskeleton and cell volume regulation

    Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Mills, J. W., 2001, In: Comparative Biochemistry and Physiology Part A. 130, p. 385-399

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1

    Andersen, A., Bentzen, Bo Hjorth, Salling, H., Klingberg, H., Kanneworff, M., Grunnet, Morten & Pedersen, Stine Helene Falsig, 2011, In: Cellular Physiology and Biochemistry. 28, 1, p. 13-24 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells

    Flinck, M., Kramer, S. H., Schnipper, J., Andersen, Anne Poder & Pedersen, Stine Helene Falsig, 2018, In: Cell Cycle. 17, 9, p. 1056-1067

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells

    Doray, A., Lemoine, R., Severin, M., Chadet, S., Lopez-Charcas, O., Héraud, A., Baron, C., Besson, P., Monteil, A., Pedersen, Stine Helene Falsig & Roger, S., 2021, In: Cells. 10, 7, 15 p., 1624.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells

    Flinck, M., Hagelund, S., Gorbatenko, A., Severin, M., Pedraz-Cuesta, E., Novak, Ivana, Stock, C. & Pedersen, Stine Helene Falsig, 2020, In: Cells. 9, 2, 22 p., 465.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca2+-Independent Manner

    Schnipper, J., Kouba, S., Hague, F., Girault, A., Rybarczyk, P., Telliez, M., Guenin, S., Tebbakha, R., Sevestre, H., Ahidouch, A., Pedersen, Stine Helene Falsig & Ouadid-Ahidouch, H., 2022, In: International Journal of Molecular Sciences . 23, 14, 20 p., 7923.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology

    Pedersen, Stine Helene Falsig & Counillon, L., 2019, In: Physiological Reviews. 99, 4, p. 2015-2113 99 p.

    Research output: Contribution to journal › Review › Research › peer-review

  25. Published

    The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells

    Giannuzzo, A., Pedersen, Stine Helene Falsig & Novak, Ivana, 2015, In: Molecular Cancer. 14, 15 p., 203.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

    Lauritzen, G., Stock, C., Lemaire, J., Lund, S. F., Jensen, M. F., Damsgaard, B., Petersen, K. S., Wiwel, M., Rønnov-Jessen, Lone, Schwab, A. & Pedersen, Stine Helene Falsig, 2012, In: Cancer Letters. 317, 2, p. 172-183 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The Na+/H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration

    Jensen, H. H., Pedersen, G. A., Morgen, J. J., Parsons, M., Pedersen, Stine Helene Falsig & Nejsum, L. N., 2019, In: Journal of Physiology. 597, 3, p. 849-867

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells.

    Pedersen, Stine Helene Falsig, Rasmussen, M., Darborg, B. V., Nylandsted, J. & Hoffmann, E. K., 2007, In: Cellular Physiology and Biochemistry. 20, 6, p. 735-50 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium

    Schneider, L., Stock, C., Dieterich, P., Jensen, B. H., Pedersen, Lotte Bang, Satir, P., Schwab, A., Christensen, Søren Tvorup & Pedersen, Stine Helene Falsig, 2009, In: Journal of Cell Biology. 185, 1, p. 163-76 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death.

    Pedersen, Stine Helene Falsig, 2006, In: Pflügers Archiv: European Journal of Physiology. 452, 3, p. 249-59 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The Na+/H+ Exchange system in Ehrlich ascites tumour cells. Effects of cell volume, phosphorylation and calcium.

    Pedersen, Stine Helene Falsig, Kramhøft, B., Jørgensen, N. K. & Hoffmann, E. K., 1994, In: Acta Physiologica (Print Edition). 151(4), p. 26A

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    The Intracellular Distal Tail of the Na+/H+ Exchanger NHE1 Is Intrinsically Disordered: Implications for NHE1 Trafficking

    Nørholm, A., Hendus-Altenburger, R., Bjerre, G., Kjærgaard, M., Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 2011, In: Biochemistry. 50, 17, p. 3469-80 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer

    Pedersen, Stine Helene Falsig, Flinck, M. & Pardo, L. A., 2021, In: International Journal of Molecular Sciences. 22, 10, 27 p., 5209.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    The Acidic Tumor Microenvironment as a Driver of Cancer

    Boedtkjer, E. & Pedersen, Stine Helene Falsig, 2020, In: Annual Review of Physiology. 82, p. 103-126

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II?

    Kjærgaard, M., Nørholm, A., Hendus-Altenburger, R., Pedersen, Stine Helene Falsig, Poulsen, F. M. & Kragelund, Birthe Brandt, 1 Aug 2010, In: Protein Science. 19, 8, p. 1555-64 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    TRP channels: an overview.

    Pedersen, Stine Helene Falsig, Owsianik, G. & Nilius, B., 2005, In: Cell Calcium. 38, 3-4, p. 233-52 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling

    Malinda, R. R., Zeeberg, K., Sharku, P. C., Ludwig, M. Q., Pedersen, Lotte Bang, Christensen, Søren Tvorup & Pedersen, Stine Helene Falsig, 2020, In: Frontiers in Oncology. 10, 15 p., 687.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism

    Miranda, M. Z., Bialik, J. F., Speight, P., Dan, Q., Yeung, T., Szaszi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2017, In: Journal of Biological Chemistry. 292, 36, p. 14902-14920 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells

    Basavappa, S., Pedersen, Stine Helene Falsig, Jørgensen, N. K., Ellory, J. C. & Hoffmann, E. K., 1998, In: J. Neurophysiol.. 79, p. 1441-1449

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Structural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1

    Nygaard, E. B., Lagerstedt, J. O., Bjerre, G., Shi, B., Budamagunta, M., Poulsen, K. A., Lundby, S. M., Rigor, R. R., Voss, J. C., Cala, P. M. & Pedersen, Stine Helene Falsig, 2011, In: The Journal of Biological Chemistry. 286, 1, p. 634-48 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Structural dynamics and regulation of the mammalian SLC9A family of Na+/H+ exchangers

    Hendus-Altenburger, R., Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2014, Current Topics in Membranes: Exchangers. Bevensee, M. O. (ed.). Elsevier, Vol. 73. p. 69-148 80 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  42. Published

    Spatially resolved analysis of microenvironmental gradient impact on cancer cell phenotypes

    Auxillos, Jamie Yam, Crouigneau, R., Li, Y. F., Dai, Yifan, Stigliani, Arnaud, Tavernaro, I., Resch-Genger, U., Sandelin, Albin Gustav, Marie, R. & Pedersen, Stine Helene Falsig, 2024, In: Science Advances. 10, 18, 17 p., eadn3448.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Snowpack fluxes of methane and carbon dioxide from high Arctic tundra

    Pirk, N., Tamstorf, M. P., Lund, M., Mastepanov, M., Pedersen, Stine Helene Falsig, Mylius, M. R., Parmentier, F. W., Christiansen, H. H. & Christensen, T. R., 2016, In: Journal of Geophysical Research: Biogeosciences. 121, 11, p. 2886-2900 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Single point mutations of aromatic residues in transmembrane helices 5 and -6 differentially affect TRPV4 activation by 4α-PDD and hypotonicity: implications for the role of the pore region in regulating TRPV4 activity

    Klausen, T. K., Janssens, A., Prenen, J., Owsianik, G., Hoffmann, E. K., Pedersen, Stine Helene Falsig & Nilius, B., 2014, In: Cell Calcium. 55, 1, p. 38-47 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Signaling mechanisms regulating the Na+/H+ Exchanger NHE1 in Pleuronectes americanus and Amphiuma tridactylum

    Holt, M. E. V., King, S. A., Rigor, R. R., Cala, P. M. & Pedersen, Stine Helene Falsig, 2003, In: The FASEB Journal. Vol. 19 (4), p. A139-A140

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Signal transduction mechanisms involved in the rgulation of NHE1 from Pseudopleuronectes Americanus red blood cells by osmotic shrinkage , ß-adrenergic stimuli, and calyculin A

    Pedersen, Stine Helene Falsig, Holt, M., King, S. A. & Cala, P. M., 2004, In: Bull. Mount Desert Island Biol. Lab. 43, p. 9-11

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Sialylation of N-glycans affects the lipid secretion governed by specialized secretory lysosomal organelles through an effect on the V-ATPase

    Khoder-Agha, F., Song, Ming, Borre, M. T., Marinova, I. N., Ye, Z., Pedersen, Stine Helene Falsig, Dabelsteen, Sally & Wandall, Hans H., 2022, In: Glycobiology. 32, 11, p. 1012-1013 2 p., P103.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  48. Published

    Shrinkage insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells.

    Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2007, In: American Journal of Physiology: Cell Physiology. 292, 5, p. C1854-66

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Separate swelling- og Ca2+-activated anion currents in Ehrlich ascites tumor cells

    Pedersen, Stine Helene Falsig, Prenen, J., Droogmans, G., Hoffmann, E. K. & Nilius, B., 1998, In: J. Membrane Biol.. 163, p. 97-110

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Sensors and signal transduction pathways in vertebrate cell volume regulation.

    Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2006, In: Contributions to Nephrology. 152, p. 54-104 50 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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