Stine Helene Falsig Pedersen
Professor
Cell Biology and Physiology
Universitetsparken 13
2100 København Ø
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HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange
Andersen, A., Poulsen, K. A., Lambert, Ian Henry & Pedersen, Stine Helene Falsig, 2009, In: American Journal of Physiology: Cell Physiology. 296, 5, p. C1227-42Research output: Contribution to journal › Journal article › Research › peer-review
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The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1
Andersen, A., Bentzen, Bo Hjorth, Salling, H., Klingberg, H., Kanneworff, M., Grunnet, Morten & Pedersen, Stine Helene Falsig, 2011, In: Cellular Physiology and Biochemistry. 28, 1, p. 13-24 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment
Andersen, Anne Poder, Flinck, M., Oernbo, E. K., Pedersen, N. B., Viuff, B. M. & Pedersen, Stine Helene Falsig, 2016, In: Molecular Cancer. 15, 18 p., 45.Research output: Contribution to journal › Journal article › Research › peer-review
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Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment
Andersen, Anne Poder, Moreira, José & Pedersen, Stine Helene Falsig, 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1638, 11 p., 20130098.Research output: Contribution to journal › Journal article › Research › peer-review
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The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms
Andersen, Anne Poder, Samsøe-Petersen, Jacob, Ørnbo, E. K., Bødtkjer, E., Moreira, José, Kveiborg, Marie & Pedersen, Stine Helene Falsig, 2018, In: International Journal of Cancer. 142, 12, p. 2529-2542 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets
Andersen, Henriette Berg, Ialchina, Renata, Pedersen, Stine Helene Falsig & Czaplinska, D., 2021, In: Cancer and Metastasis Reviews. 40, 4, p. 1093-1114 22 p.Research output: Contribution to journal › Review › Research › peer-review
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Propionic acid secreted from propionibacteria induces NKG2D ligand expression on human-activated T lymphocytes and cancer cells
Andresen, Lars, Hansen, K. A., Jensen, H., Pedersen, Stine Helene Falsig, Stougaard, P., Hansen, H. R., Jurlander, J. & Skov, Søren, 2009, In: Journal of Immunology. 183, 2, p. 897-906 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.Research output: Contribution to journal › Journal article › Research › peer-review
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Spatially resolved analysis of microenvironmental gradient impact on cancer cell phenotypes
Auxillos, Jamie Yam, Crouigneau, R., Li, Y. F., Dai, Yifan, Stigliani, Arnaud, Tavernaro, I., Resch-Genger, U., Sandelin, Albin Gustav, Marie, R. & Pedersen, Stine Helene Falsig, 2024, In: Science Advances. 10, 18, 17 p., eadn3448.Research output: Contribution to journal › Journal article › Research › peer-review
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Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer
Avnet, S., Baldini, N., Brisson, L., Pedersen, Stine Helene Falsig, Porporato, P. E., Sonveaux, P., Szabadkai, G. & Pastorekova, S., 2019, In: Frontiers in Oncology. 9, 5 p., 1332.Research output: Contribution to journal › Review › Research › peer-review
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O-glycan initiation directs distinct biological pathways and controls epithelial differentiation
Bagdonaite, Ieva , Pallesen, E. M. H., Ye, Z., Vakhrushev, Sergey, Marinova, I. N., Nielsen, Mathias Alexander Ingemann, Kramer, S. H., Pedersen, Stine Helene Falsig, Joshi, Hiren Jitendra, Bennett, Eric Paul, Dabelsteen, Sally & Wandall, Hans H., 2020, In: EMBO Reports. 21, 6, 17 p., e48885.Research output: Contribution to journal › Journal article › Research › peer-review
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Annual Meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer
Baldini, N., de Milito, A., Feron, O., Gillies, R. J., Michiels, C., Otto, A. M., Pastoreková, S., Pedersen, Stine Helene Falsig, Porporato, P. E., Sonveaux, P., Supuran, C. T. & Avnet, S., 4 Jul 2017, In: Frontiers in Pharmacology. 8, 5 p., 411.Research output: Contribution to journal › Comment/debate › Research
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Metabolism and microenvironment in cancer plasticity
Baldini, N., Sonveaux, P., De Milito, A., Supuran, C. T., Otto, A. M., Stock, C. M., Pedersen, Stine Helene Falsig, Favicchio, R. & Avnet, S., 2016, In: Cancer & Metabolism. 4, Supplement 1, 7 p., 1.Research output: Contribution to journal › Comment/debate › Research
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Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells
Basavappa, S., Pedersen, Stine Helene Falsig, Jørgensen, N. K., Ellory, J. C. & Hoffmann, E. K., 1998, In: J. Neurophysiol.. 79, p. 1441-1449Research output: Contribution to journal › Journal article › Research › peer-review
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Roles of Rho GTPases in the Regulatory Volume Decrease Process in NIH3T3 Mouse Fibroblasts
Beisner, K. H., Hougaard, C., Lambert, Ian Henry, Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2001.Research output: Contribution to conference › Conference abstract for conference › Research
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Profibrotic epithelial phenotype: a central role for MRTF and TAZ
Bialik, J. F., Ding, M., Speight, P., Dan, Q., Miranda, M. Z., Di Ciano-Oliveira, C., Kofler, M. M., Rotstein, O. D., Pedersen, Stine Helene Falsig, Szászi, K. & Kapus, A., 2019, In: Scientific Reports. 9, p. 1-14 4323.Research output: Contribution to journal › Journal article › Research › peer-review
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The Acidic Tumor Microenvironment as a Driver of Cancer
Boedtkjer, E. & Pedersen, Stine Helene Falsig, 2020, In: Annual Review of Physiology. 82, p. 103-126Research output: Contribution to journal › Review › Research › peer-review
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Contribution of Na+,HCO3--cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7)
Bødtkjer, E., Moreira, José, Mele, M., Vahl, P., Wielenga, V. T., Christiansen, P. M., Jensen, V. E. D., Pedersen, Stine Helene Falsig & Aalkjær, C., 2013, In: International Journal of Cancer. 132, 6, p. 1288-1299 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy
Bødtkjer, E., Bunch, Lennart & Pedersen, Stine Helene Falsig, 2012, In: Current Pharmaceutical Design. 18, 10, p. 1345-1371 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Response to Schushan et al.: Two conflicting NHE1 model structures: compatibility with experimental data and implications for the transport mechanism
Cala, P. M. & Pedersen, Stine Helene Falsig, 2011, In: Journal of Biological Chemistry. 286, 21, p. le10 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion
Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair
Christensen, Søren Tvorup, Pedersen, Stine Helene Falsig, Satir, P., Veland, I. R. & Schneider, L., 2008, In: Current Topics in Developmental Biology. 85, p. 261-301 40 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PDGFR alpha signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90(RSK) and AKT signaling pathways
Clement, Ditte Lynge, Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen, Stine Helene Falsig & Christensen, Søren Tvorup, 2013, In: Journal of Cell Science. 126, 4, p. 953-965 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells
Cuesta, E. P., Christensen, S., Jensen, Anders A., Jensen, N. F., Bunch, Lennart, Rømer, M. U. K., Brünner, N., Stenvang, Jan & Pedersen, Stine Helene Falsig, 2015, In: B M C Cancer. 15, 1, 17 p., 411.Research output: Contribution to journal › Journal article › Research › peer-review
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3D multicellular models to study the regulation and roles of acid-base transporters in breast cancer
Czaplinska, D., Elingaard-Larsen, L. O., Rolver, M. G., Severin, M. & Pedersen, Stine Helene Falsig, 20 Dec 2019, In: Biochemical Society Transactions. 47, 6, p. 1689-1700 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness
Czaplinska, D., Ialchina, Renata, Andersen, Henriette Berg, Yao, Jiayi, Stigliani, Arnaud, Dannesboe, Johs, Flinck, M., Chen, X., Mitrega, J., Gnosa, S. P., Dmytriyeva, O., Alves, F., Napp, J., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2023, In: International Journal of Cancer. 152, 6, p. 1210-1225 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Causal relationship between NHE1, NKCC1, MAPKs and ERM proteins after osmotic shrinkage in Ehrlich Lettremouse ascites tumor cells.
Darborg, B., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2005, In: The FASEB Journal. 5, p. A1155Research output: Contribution to journal › Conference article › Research › peer-review
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The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells
Doray, A., Lemoine, R., Severin, M., Chadet, S., Lopez-Charcas, O., Héraud, A., Baron, C., Besson, P., Monteil, A., Pedersen, Stine Helene Falsig & Roger, S., 2021, In: Cells. 10, 7, 15 p., 1624.Research output: Contribution to journal › Journal article › Research › peer-review
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Aquaporin water channels affect the response of conventional anticancer therapies of 3D grown breast cancer cells
Edamana, S., Pedersen, Stine Helene Falsig & Nejsum, L. N., 2023, In: Biochemical and Biophysical Research Communications. 639, p. 126-133 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell Volume Regulation and Signaling in 3T3-L1 Pre-adipocytes and Adipocytes: on the Possible Roles of Caveolae, Insulin Receptors, FAK and ERK1/2
Eduardsen, K., Larsen, S., Novak, Ivana, Lambert, Ian Henry, Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2011, In: Cellular Physiology and Biochemistry. 28, 6, p. 1231-46 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression
Elingaard-Larsen, L. O., Rolver, M. G., Sørensen, E. E. & Pedersen, Stine Helene Falsig, 2022, From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. Stock, C. & Pardo, L. A. (eds.). Springer, p. 1-38 38 p. (Reviews of Physiology, Biochemistry and Pharmacology, Vol. 182).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Roles of pH in control of cell proliferation
Flinck, M., Kramer, S. H. & Pedersen, Stine Helene Falsig, 2018, In: Acta Physiologica. 223, 3, p. 1-17 e13068.Research output: Contribution to journal › Review › Research › peer-review
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The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells
Flinck, M., Kramer, S. H., Schnipper, J., Andersen, Anne Poder & Pedersen, Stine Helene Falsig, 2018, In: Cell Cycle. 17, 9, p. 1056-1067Research output: Contribution to journal › Journal article › Research › peer-review
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The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells
Flinck, M., Hagelund, S., Gorbatenko, A., Severin, M., Pedraz-Cuesta, E., Novak, Ivana, Stock, C. & Pedersen, Stine Helene Falsig, 2020, In: Cells. 9, 2, 22 p., 465.Research output: Contribution to journal › Journal article › Research › peer-review
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The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells
Giannuzzo, A., Pedersen, Stine Helene Falsig & Novak, Ivana, 2015, In: Molecular Cancer. 14, 15 p., 203.Research output: Contribution to journal › Journal article › Research › peer-review
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Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes
Gorbatenko, A., Olesen, C. W., Loebl, N., Sigurdsson, H. H., Bianchi, C., Pedraz Cuesta, E., Christiansen, Jan & Pedersen, Stine Helene Falsig, 2016, In: Biochemical Journal. 473, 21, p. 4027-4044 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in ehrlich lettré ascites cells through a mechanism involving p38 mitogen-activated protein kinase
Gorbatenko, A., Wiwel, M., Klingberg, H., Nielsen, A. B., Kapus, A. & Pedersen, Stine Helene Falsig, 2011, In: Journal of Cellular Physiology. 226, 11, p. 2857-2868 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation and roles of bicarbonate transporters in cancer
Gorbatenko, A., Olesen, C. W., Bødtkjer, E. & Pedersen, Stine Helene Falsig, 2014, In: Frontiers in Physiology. 5, 15 p., 130.Research output: Contribution to journal › Journal article › Research › peer-review
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ErbB2 upregulates the Na+,HCO3- -cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Krüppel-like factor 4
Gorbatenko, A., Olesen, C. W., Mørup, N., Thiel, G., Kallunki, T., Valen, E. & Pedersen, Stine Helene Falsig, 2014, In: F A S E B Journal. 28, 1, p. 350-363 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503
Gorbatenko, A., Søkilde, R., Sorensen, E. E., Newie, I., Persson, H., Morancho, B., Arribas, J., Litman, Thomas, Rovira, C. & Pedersen, Stine Helene Falsig, 2019, In: Scientific Reports. 9, 1, p. 1-16 3352.Research output: Contribution to journal › Journal article › Research › peer-review
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Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes
Haxholm, G. W., Nikolajsen, L. F., Olsen, Johan Gotthardt, Fredsted, J., Larsen, F. H., Goffin, V., Pedersen, Stine Helene Falsig, Brooks, A. J., Waters, M. J. & Kragelund, Birthe Brandt, 2015, In: Biochemical Journal. 468, 3, p. 495-506 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, Lise Margrethe, Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, Birthe Brandt, Pedersen, Stine Helene Falsig & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural dynamics and regulation of the mammalian SLC9A family of Na+/H+ exchangers
Hendus-Altenburger, R., Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2014, Current Topics in Membranes: Exchangers. Bevensee, M. O. (ed.). Elsevier, Vol. 73. p. 69-148 80 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)
Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2
Hendus-Altenburger, R., Pedraz Cuesta, E., Olesen, C. W., Papaleo, E., Schnell, J. A., Hopper, J. T. S., Robinson, C. V., Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 2016, In: BMC Biology. 14, 17 p., 31.Research output: Contribution to journal › Journal article › Research › peer-review
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The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity
Hendus-Altenburger, R., Vogensen, J., Pedersen, E. S., Luchini, A., Araya-Secchi, R., Bendsoe, A. H., Prasad, N. S., Prestel, Andreas, Cardenas, M., Pedraz-Cuesta, E., Arleth, Lise, Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 3 Dec 2020, In: Communications Biology . 3, 1, 18 p., 731.Research output: Contribution to journal › Journal article › Research › peer-review
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Prophylactic effect of citalopram in unipolar, recurrent depression
Hochstrasser, B., Isaksen, P. M., Koponen, H., Lauritzen, L., Mahnert, F. A., Rouillon, F., Wade, A. G., Andersen, M., Pedersen, Stine Helene Falsig, Swart, J. C. G. D. & Nil, R., 2001, In: British Journal of Psychiatry. 178, p. 304-310Research output: Contribution to journal › Journal article › Research › peer-review
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Cell volume homeostatic mechanisms: effectors and signalling pathways
Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 27 Jan 2011, In: Acta Physiologica. 202, 3, p. 465–485Research output: Contribution to journal › Journal article › Research › peer-review
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Shrinkage insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells.
Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2007, In: American Journal of Physiology: Cell Physiology. 292, 5, p. C1854-66Research output: Contribution to journal › Journal article › Research › peer-review
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Effectors and signaling events activated by cell shrinkage in ehrlich ascites tumor cells: implications for cell proliferation and programmed cell death.
Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2004, In: Advances in Experimental Medicine and Biology. 559, p. 169-78 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8742
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3548
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Annual Meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer
Research output: Contribution to journal › Comment/debate › Research
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2070
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Cell volume regulation in epithelial physiology and cancer
Research output: Contribution to journal › Review › Research › peer-review
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
Research output: Contribution to journal › Journal article › Research › peer-review
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