An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer
Research output: Contribution to journal › Journal article › Research › peer-review
The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.
Original language | English |
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Journal | ISME Journal |
Volume | 12 |
Issue number | 9 |
Pages (from-to) | 2330-2334 |
Number of pages | 5 |
ISSN | 1751-7362 |
DOIs | |
Publication status | Published - 2018 |
ID: 199418167