PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53

Research output: Contribution to journal › Journal article › Research › peer-review

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PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. / Zandi, Roza; Selivanova, Galina; Christensen, Camilla Laulund; Gerds, Thomas Alexander; Willumsen, Berthe Marie; Poulsen, Hans Skovgaard.

In: Clinical Cancer Research, Vol. 17, No. 9, 01.05.2011, p. 2830-2841.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zandi, R, Selivanova, G, Christensen, CL, Gerds, TA, Willumsen, BM & Poulsen, HS 2011, 'PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53', Clinical Cancer Research, vol. 17, no. 9, pp. 2830-2841. https://doi.org/10.1158/1078-0432.CCR-10-3168

APA

Zandi, R., Selivanova, G., Christensen, C. L., Gerds, T. A., Willumsen, B. M., & Poulsen, H. S. (2011). PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. Clinical Cancer Research, 17(9), 2830-2841. https://doi.org/10.1158/1078-0432.CCR-10-3168

Vancouver

Zandi R, Selivanova G, Christensen CL, Gerds TA, Willumsen BM, Poulsen HS. PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. Clinical Cancer Research. 2011 May 1;17(9):2830-2841. https://doi.org/10.1158/1078-0432.CCR-10-3168

Author

Zandi, Roza ; Selivanova, Galina ; Christensen, Camilla Laulund ; Gerds, Thomas Alexander ; Willumsen, Berthe Marie ; Poulsen, Hans Skovgaard. / PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. In: Clinical Cancer Research. 2011 ; Vol. 17, No. 9. pp. 2830-2841.

Bibtex

@article{18f07b138df346a49642bcc58e8d1b51,
title = "PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53",
abstract = "Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis, necessitating the need to develop new and efficient treatment modalities. PRIMA-1(Met) (p53-dependent reactivation of massive apoptosis), also known as APR-246, is a small molecule, which restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. Since p53 is mutated in more than 90% of SCLC, we investigated the ability of PRIMA-1(Met) to induce apoptosis and inhibit tumor growth in SCLC with different p53 mutations.",
author = "Roza Zandi and Galina Selivanova and Christensen, {Camilla Laulund} and Gerds, {Thomas Alexander} and Willumsen, {Berthe Marie} and Poulsen, {Hans Skovgaard}",
note = "{\textcopyright}2011 AACR.",
year = "2011",
month = may,
day = "1",
doi = "10.1158/1078-0432.CCR-10-3168",
language = "English",
volume = "17",
pages = "2830--2841",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research (A A C R)",
number = "9",

}

RIS

TY - JOUR

T1 - PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53

AU - Zandi, Roza

AU - Selivanova, Galina

AU - Christensen, Camilla Laulund

AU - Gerds, Thomas Alexander

AU - Willumsen, Berthe Marie

AU - Poulsen, Hans Skovgaard

N1 - ©2011 AACR.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis, necessitating the need to develop new and efficient treatment modalities. PRIMA-1(Met) (p53-dependent reactivation of massive apoptosis), also known as APR-246, is a small molecule, which restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. Since p53 is mutated in more than 90% of SCLC, we investigated the ability of PRIMA-1(Met) to induce apoptosis and inhibit tumor growth in SCLC with different p53 mutations.

AB - Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis, necessitating the need to develop new and efficient treatment modalities. PRIMA-1(Met) (p53-dependent reactivation of massive apoptosis), also known as APR-246, is a small molecule, which restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. Since p53 is mutated in more than 90% of SCLC, we investigated the ability of PRIMA-1(Met) to induce apoptosis and inhibit tumor growth in SCLC with different p53 mutations.

U2 - 10.1158/1078-0432.CCR-10-3168

DO - 10.1158/1078-0432.CCR-10-3168

M3 - Journal article

C2 - 21415220

VL - 17

SP - 2830

EP - 2841

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 9

ER -

ID: 33923684