Extrachromosomal circular DNA in cancer: history, current knowledge, and methods

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

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Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important roles in cancer pathogenesis, evolution of tumor heterogeneity, and therapeutic resistance. It is known under many names, including very large cancer-specific circular extrachromosomal DNA (ecDNA), which carries oncogenes and is often amplified in cancer cells. Our understanding of eccDNA has historically been limited and fragmented. To provide better a context of new and previous research on eccDNA, in this review we give an overview of the various names given to eccDNA at different times. We describe the different mechanisms for formation of eccDNA and the methods used to study eccDNA thus far. Finally, we explore the potential clinical value of eccDNA.

OriginalsprogEngelsk
TidsskriftTrends in Genetics
Vol/bind38
Udgave nummer7
Sider (fra-til)766-781
Antal sider16
ISSN0168-9525
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
J.B.N. is funded by Innovation Fund Denmark ( 8088-00049B ). Work in B.R.’s laboratory is funded by Innovation Fund Denmark ( 8088-00049B ), VILLUM FONDEN ( 00023247 ), Independent Research Fund Denmark ( FNU 6108-00171B ), Novo Nordisk Foundation ( NNF18OC0053139 ) and the European Union’s Horizon 2020 Research and Innovation Programme ( 899417 ). Work in Y.L.’s laboratory is funded by the European Union’s Horizon 2020 Research and Innovation Programme ( 899417 ) and the Novo Nordisk Foundation ( NNF21OC0072031 ). We thank Chris Tachibana for proofreading of the manuscript and Carl H. R. dos Santos for illustrations.

Funding Information:
J.B.N. is funded by Innovation Fund Denmark (8088-00049B). Work in B.R.?s laboratory is funded by Innovation Fund Denmark (8088-00049B), VILLUM FONDEN (00023247), Independent Research Fund Denmark (FNU 6108-00171B), Novo Nordisk Foundation (NNF18OC0053139) and the European Union's Horizon 2020 Research and Innovation Programme (899417). Work in Y.L.?s laboratory is funded by the European Union's Horizon 2020 Research and Innovation Programme (899417) and the Novo Nordisk Foundation (NNF21OC0072031). We thank Chris Tachibana for proofreading of the manuscript and Carl H. R. dos Santos for illustrations. The authors declare no conflict of interest.

Publisher Copyright:
© 2022 The Authors

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