Vibe Hallundbæk Østergaard
Associate Professor
Functional Genomics
Ole Maaløes Vej 5
2200 København N.
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A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination
Ambjørn, Sara Marie, Duxin, Julien, Hertz, Emil Peter Thrane, Nasa, I., Duro, Joana Maria, Kruse, Thomas, Lopez-Mendez, B., Rymarczyk, B., Cressey, L. E., van Overeem Hansen, T., Kettenbach, A. N., Østergaard, Vibe Hallundbæk, Lisby, Michael & Nilsson, Jakob, 2021, In: Nature Communications. 12, 1, 11 p., 5748.Research output: Contribution to journal › Journal article › Research › peer-review
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A distinct role for recombination repair factors in an early cellular response to transcription-replication conflicts
Shao, Xin, Joergensen, A. M., Howlett, N. G., Lisby, Michael & Østergaard, Vibe Hallundbæk, 2020, In: Nucleic Acids Research. 48, 10, p. 5467-5484 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A human topoisomerase IIα heterodimer with only one ATP binding site can go through successive catalytic cycles
Skouboe, C., Bjergbaek, L., Østergaard, Vibe Hallundbæk, Larsen, M. K., Knudsen, B. R. & Andersen, A. H., 21 Feb 2003, In: Journal of Biological Chemistry. 278, 8, p. 5768-5774 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A mutational atlas for Parkin proteostasis
Clausen, L., Voutsinos, Vasileios, Cagiada, Matteo, Johansson, Kristoffer Enøe, Grønbæk-Thygesen, Martin, Nariya, S., Powell, R. L., Have, M. K. N., Østergaard, Vibe Hallundbæk, Stein, Amelie, Fowler, D. M., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Nature Communications. 15, 1, 17 p., 1541.Research output: Contribution to journal › Journal article › Research › peer-review
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Common Chromosomal Fragile Sites - Conserved Failure Stories
Voutsinos, Vasileios, Munk, S. H. N. & Østergaard, Vibe Hallundbæk, 2018, In: Genes. 9, 12, p. 1-16 580.Research output: Contribution to journal › Review › Research › peer-review
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Deubiquitination of FANCD2 Is Required for DNA Crosslink Repair
Østergaard, Vibe Hallundbæk, Langevin, F., Kuiken, H. J., Pace, P., Niedzwiedz, W., Simpson, L. J., Ohzeki, M., Takata, M., Sale, J. E. & Patel, K. J., 14 Dec 2007, In: Molecular Cell. 28, 5, p. 798-809 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193
Østergaard, Vibe Hallundbæk, Knudsen, B. R. & Andersen, A. H., 2 Jul 2004, In: Journal of Biological Chemistry. 279, 27, p. 28100-28105 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination
Germann, S. M., Østergaard, Vibe Hallundbæk, Haas, C., Salis, P., Motegi, A. & Lisby, Michael, 2011, In: D N A Repair. 10, 2, p. 210-224 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Emerging roles of the CIP2A–TopBP1 complex in genome integrity
Ummethum, Henning Ole, Li, Jiayi, Lisby, Michael & Østergaard, Vibe Hallundbæk, 2023, In: NAR Cancer. 5, 4, 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells
Pentzold, C., Shah, S. A., Hansen, Niels Richard, Le Tallec, B., Seguin-Orlando, A., Debatisse, M., Lisby, Michael & Østergaard, Vibe Hallundbæk, 2018, In: Nucleic Acids Research. 46, 3, p. 1280-1294 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functions of TopBP1 in preserving genome integrity during mitosis
Bagge, J., Østergaard, Vibe Hallundbæk & Lisby, Michael, 2021, In: Seminars in Cell and Developmental Biology. 113, p. 57-64 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Hindering the strand passage reaction of human topoisomerase IIα without disturbing DNA cleavage, ATP hydrolysis, or the operation of the N-terminal clamp
Østergaard, Vibe Hallundbæk, Giangiacomo, L., Bjergbaek, L., Knudsen, B. R. & Andersen, A. H., 2 Jul 2004, In: Journal of Biological Chemistry. 279, 27, p. 28093-28099 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Large Intronic Deletion of the Fragile Site Gene PRKN Dramatically Lowers Its Fragility Without Impacting Gene Expression
Munk, S. H. N., Voutsinos, Vasileios & Østergaard, Vibe Hallundbæk, 2021, In: Frontiers in Genetics. 12, 9 p., 695172.Research output: Contribution to journal › Journal article › Research › peer-review
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RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40
Simpson, L. J., Ross, A. L., Szüts, D., Alviani, C. A., Østergaard, Vibe Hallundbæk, Patel, K. J. & Sale, J. E., 1 Sep 2006, In: EMBO Reports. 7, 9, p. 927-932 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells
Østergaard, Vibe Hallundbæk, Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, Simon Holst, Mailand, Niels & Lisby, Michael, 2012, In: D N A Repair. 11, 11, p. 892–905 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Moudry, P., Watanabe, K., Wolanin, K. M., Bartkova, J., Wassing, I. E., Watanabe, S., Strauss, R., Pedersen, R. T., Østergaard, Vibe Hallundbæk, Lisby, Michael, Andújar-Sánchez, M., Maya-Mendoza, A., Esashi, F., Lukas, Jiri & Bartek, J., 2016, In: The Journal of Cell Biology. 212, 3, p. 281-288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
The QTK Loop is Essential for the Communication between the N-Terminal ATPase Domain and the Central Cleavage-Ligation Region in Human Topoisomerase IIα
Bendsen, S., Østergaard, Vibe Hallundbæk, Skouboe, C., Brinch, M., Knudsen, B. R. & Andersen, A. H., 2009, In: Biochemistry. 48, 27, p. 6508-6515 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Transducer Domain Is Important for Clamp Operation in Human DNA Topoisomerase IIα
Østergaard, Vibe Hallundbæk, Bjergbaek, L., Skouboe, C., Giangiacomo, L., Knudsen, B. R. & Andersen, A. H., 16 Jan 2004, In: Journal of Biological Chemistry. 279, 3, p. 1684-1691 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, Smaragda, Simonsen, Anne Katrine Wrist, Bagge, Keerthana Stine Viswalingam, Gonzalez, L., Hickson, Ian David, Østergaard, Vibe Hallundbæk, Mankouri, H. W., Sung, P. & Lisby, Michael, 2020, In: Cell Reports. 32, 1, 25 p., 107849.Research output: Contribution to journal › Journal article › Research › peer-review
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The genetic and biochemical basis of FANCD2 Monoubiquitination
Rajendra, E., Østergaard, Vibe Hallundbæk, Langevin, F., Wang, M., Dornan, G. L., Patel, K. J. & Passmore, L. A., 2014, In: Molecular Cell. 54, 5, p. 858-869 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line
Mohiuddin, M., Kobayashi, S., Keka, I. S., Guilbaud, G., Sale, J., Narita, Takeo, Abdel-Aziz, H. I., Wang, X., Ogawa, S., Sasanuma, H., Chiu, R., Østergaard, Vibe Hallundbæk, Lisby, Michael & Takeda, S., Apr 2016, In: DNA Repair. 40, p. 67-76 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells
Pedersen, R. T., Kruse, Thomas, Nilsson, Jakob, Østergaard, Vibe Hallundbæk & Lisby, Michael, 2015, In: Journal of Cell Biology. 210, 4, p. 565-582 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TopBP1 makes the final call for repair on the verge of cell division
Østergaard, Vibe Hallundbæk & Lisby, Michael, 2016, In: Molecular & Cellular Oncology. 3, 2, 3 p., e1093066.Research output: Contribution to journal › Review › Research › peer-review
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TopBP1-mediated DNA processing during mitosis
Gallina, I., Christiansen, S. K., Pedersen, R. T., Lisby, Michael & Østergaard, Vibe Hallundbæk, 2016, In: Cell Cycle. 15, 2, p. 176-183 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability
Germann, S. M., Schramke, V., Pedersen, R. T., Gallina, I., Eckert-Boulet, N., Østergaard, Vibe Hallundbæk & Lisby, Michael, 2014, In: Journal of Cell Biology. 204, 1, p. 45-59 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11903628
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The genetic and biochemical basis of FANCD2 Monoubiquitination
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
327
downloads
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
249
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FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published