Section for Functional Genomics

The genetic code of life is essential to understanding biological processes in all organisms from the single cell to the entire human body. Today the complete genome of more than 1000 organisms have been sequenced. The genetic information that is now available is greatly facilitating our ability to investigate genetic mechanisms that control the biological processes of life with important implications for human health and our environment.

In the Section for Functional Genomics, our research is aimed at understanding the expression, regulation and propagation of genomes using suitable model organisms, for example archaea, plants, and yeast, as well as vertebrate cell lines. Some of our research topics include genome stability, cell cycle regulation and differentiation, DNA repair, homologous recombination, DNA building blocks (dNTP pools), gene expression, transcriptional silencing, chromatin structure and dynamics, innate immunity, programmed cell death, signal transduction, DNA replication, genome variability and evolution, and virus biology.