Kresten Lindorff-Larsen
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
- 2022
- Published
The role of water coordination in the pH-dependent gating of hAQP10
Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transient exposure of a buried phosphorylation site in an autoinhibited protein
Orioli, S., Henning Hansen, C. G. & Lindorff-Larsen, Kresten, 2022, In: Biophysical Journal. 121, 1, p. 91-101 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
VM i molekylære puslespil
Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 16 Apr 2021, In: Weekendavisen: Ideer. 15, p. 11Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
- Published
Molekylære stavefejl
Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 28 Jan 2021, In: Weekendavisen, Ideer.Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
- Published
A dual-reporter system for investigating and optimizing protein translation and folding in E. coli
Zutz, A., Hamborg, L., Pedersen, L. E., Kassem, M. M., Papaleo, E., Koza, A., Herrgård, M. J., Ingemann Jensen, S., Teilum, Kaare, Lindorff-Larsen, Kresten & Nielsen, A. T., 2021, In: Nature Communications. 12, 15 p., 6093.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accurate model of liquid-liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties
Tesei, Giulio, Schulze, T. K., Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 44, 10 p., e2111696118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12
Weinhäupl, K., Wang, Y., Hessel, A., Brennich, M., Lindorff-Larsen, Kresten & Schanda, P., 2021, In: Structure. 29, 9, p. 1065-1073.e4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Charge Interactions in a Highly Charge-Depleted Protein
Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Y., Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational and Experimental Assessment of Backbone Templates for Computational Redesign of the Thioredoxin Fold
Marin, Frederikke Isa, Johansson, Kristoffer Enøe, O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: The Journal of Physical Chemistry B. 125, 40, p. 11141-11149Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Conformational Ensembles of Noncoding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations
Bottaro, S., Bussi, G. & Lindorff-Larsen, Kresten, 2021, In: Journal of the American Chemical Society. 143, 22, p. 8333-8343Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DEER-PREdict: Software for efficient calculation of spin-labeling EPR and NMR data from conformational ensembles
Tesei, Giulio, Martins, J. M., Kunze, M. B. A., Wang, Y., Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: PLOS Computational Biology. 17, 1, 18 p., e1008551.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks
Koehler Leman, J., Lyskov, S., Lewis, S. M., Adolf-Bryfogle, J., Alford, R. F., Barlow, K., Ben-Aharon, Z., Farrell, D., Fell, J., Hansen, W. A., Harmalkar, A., Jeliazkov, J., Kuenze, G., Krys, J. D., Ljubetič, A., Loshbaugh, A. L., Maguire, J., Moretti, R., Mulligan, V. K., Nance, M. L. & 30 others, , 2021, In: Nature Communications. 12, 15 p., 6947.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fitting Side-Chain NMR Relaxation Data Using Molecular Simulations
Kümmerer, Felix, Orioli, S., Harding-Larsen, D., Hoffmann, F., Gavrilov, Y., Teilum, Kaare & Lindorff-Larsen, Kresten, 2021, In: Journal of Chemical Theory and Computation. 17, 8, p. 5262-5275 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Force Field Effects in Simulations of Flexible Peptides with Varying Polyproline II Propensity
Jephthah, S., Pesce, Francesco, Lindorff-Larsen, Kresten & Skepö, M., 2021, In: Journal of Chemical Theory and Computation. 17, 10, p. 6634-6646 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
Martin, E. W., Thomasen, Emil, Milkovic, N. M., Cuneo, M. J., Grace, C. R., Nourse, A., Lindorff-Larsen, Kresten & Mittag, T., 2021, In: Nucleic Acids Research. 49, 5, p. 2931-2945 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Linking thermodynamics and measurements of protein stability
Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Protein engineering, design & selection : PEDS. 34, 13 p., gzab002.Research output: Contribution to journal › Review › Research › peer-review
- Published
Mapping the degradation pathway of a disease-linked aspartoacylase variant
Gersing, S. K., Wang, Y., Grønbæk-Thygesen, Martin, Kampmeyer, Caroline, Bjørnkjær, Lene, Willemoës, Martin, Andréasson, C., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2021, In: PLOS Genetics. 17, 4, 28 p., e1009539.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition
Nielsen, S. V., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2021, In: PLOS Genetics. 17, 4, 6 p., e1009496.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the Potential of Machine Learning to Examine the Relationship Between Sequence, Structure, Dynamics and Function of Intrinsically Disordered Proteins
Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 20, 22 p., 167196.Research output: Contribution to journal › Review › Research › peer-review
- Published
Order and disorder - An integrative structure of the full-length human growth hormone receptor
Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Y., Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Properdin oligomers adopt rigid extended conformations supporting function
Pedersen, D. V., Pedersen, M. N., Mazarakis, S. M. M., Wang, Y., Lindorff-Larsen, Kresten, Arleth, Lise & Andersen, G. R., 2021, In: eLife. 10, 22 p., e63356.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods
Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Refining conformational ensembles of flexible proteins against small-angle x-ray scattering data
Pesce, Francesco & Lindorff-Larsen, Kresten, 2021, In: Biophysical Journal. 120, 22, p. 5124-5135 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional variation of chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus
Madland, E., Forsberg, Z., Wang, Y., Lindorff-Larsen, Kresten, Niebisch, A., Modregger, J., Eijsink, V. G. H., Aachmann, F. L. & Courtade, G., 2021, In: Journal of Biological Chemistry. 297, 4, 17 p., 101084.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli
Hamborg, L., Granata, D., Olsen, Johan Gotthardt, Roche, J. V., Pedersen, L. E., Nielsen, A. T., Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Communications Biology . 4, 9 p., 980.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs
Lambrughi, M., Maiani, E., Fas, B. A., Shaw, G. S., Kragelund, Birthe Brandt, Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, G. & Papaleo, E., 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 676235.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance
Cagiada, Matteo, Johansson, Kristoffer Enøe, Valanciute, A., Nielsen, S. V., Hartmann-Petersen, Rasmus, Yang, J. J., Fowler, D. M., Stein, Amelie & Lindorff-Larsen, Kresten, 2021, In: Molecular Biology and Evolution. 38, 8, p. 3235-3246Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations.
Bengtsen, T., Midtgaard, S. R., Holm-Janas, Viktor, Kjølbye, L. R., Johansen, Nicolai Tidemand, Tesei, Giulio, Bottaro, S., Schiøtt, B., Arleth, Lise & Lindorff-Larsen, Kresten, 30 Jul 2020, In: eLife. 9, 24 p., e56518.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small-angle Neutron Scattering Shows that the Solution Structures of the Bacterial Mg2+-Channel CorA are Overall Similar with and without Mg2+ Bound
Arleth, Lise, Johansen, Nicolai Tidemand, Bengtsen, T., Larsen, A. H., Tidemand, Frederik Grønbæk, Pomorski, Thomas Guenther & Lindorff-Larsen, Kresten, 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl. 1, p. 12A 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Classifying disease-associated variants using measures of protein activity and stability
Jepsen, M. M., Fowler, D. M., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 91-107Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
Abildgaard, A. B., Gersing, S. K., Larsen-Ledet, Sven, Nielsen, S. V., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: Biomolecules. 10, 8, 24 p., 1141.Research output: Contribution to journal › Review › Research › peer-review
- Published
Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution
Nørgrd Larsen, Andreas, Wang, Y., Bottaro, S., Grudinin, S., Arleth, Lise & Lindorff-Larsen, Kresten, 2020, In: P L o S Computational Biology. 16, 4, 29 p., e1007870.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computing, Analyzing, and Comparing the Radius of Gyration and Hydrodynamic Radius in Conformational Ensembles of Intrinsically Disordered Proteins
Ahmed, M. C., Crehuet, R. & Lindorff-Larsen, Kresten, 2020, Intrinsically Disordered Proteins: Methods and Protocols. Kragelund, B. B. & Skriver, K. (eds.). Humana Press, p. 429-445 17 p. (Methods in Molecular Biology, Vol. 2141).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation
Bjørnkjær, Lene, Stein, Amelie, Grønbæk-Thygesen, Martin, Nygaard, L., Søltoft, C. L., Nielsen, S. V., Lisby, Michael, Ravid, T., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: PLOS Genetics. 16, 11, 28 p., e1009187.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global analysis of protein stability by temperature and chemical denaturation
Hamborg, L., Horsted, E. W., Johansson, Kristoffer Enøe, Willemoës, Martin, Lindorff-Larsen, Kresten & Teilum, Kaare, 2020, In: Analytical Biochemistry. 605, 7 p., 113863.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How to learn from inconsistencies: Integrating molecular simulations with experimental data
Orioli, S., Nørgrd Larsen, Andreas, Bottaro, S. & Lindorff-Larsen, Kresten, 2020, Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly. Strodel, B. & Barz, B. (eds.). Academic Press, p. 123-176 54 p. (Progress in Molecular Biology and Translational Science, Vol. 170).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Integrating Molecular Simulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach
Bottaro, S., Bengtsen, T. & Lindorff-Larsen, Kresten, 2020, Structural Bioinformatics: Methods and Protocols. Gáspári, Z. (ed.). Humana Press, p. 219-240 22 p. (Methods in Molecular Biology, Vol. 2112).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Integrating NMR and simulations reveals motions in the UUCG tetraloop
Bottaro, S., Nichols, P. J., Vögeli, B., Parrinello, M. & Lindorff-Larsen, Kresten, 2020, In: Nucleic Acids Research. 48, 11, p. 5839-5848 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel HARS2 missense variants identified in individuals with sensorineural hearing impairment and Perrault syndrome
Karstensen, H. G., Rendtorff, N. D., Hindbæk, L. S., Colombo, R., Stein, Amelie, Birkebæk, N. H., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten, Højland, A. T., Petersen, M. B. & Tranebjærg, Lisbeth, 2020, In: European Journal of Medical Genetics. 63, 3, 6 p., 103733.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein Dynamics Enables Phosphorylation of Buried Residues in Cdk2/Cyclin-A-Bound p27
Henriques, J. & Lindorff-Larsen, Kresten, 2020, In: Biophysical Journal. 119, 10, p. 2010-2018 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein destabilization and degradation as a mechanism for hereditary disease
Nielsen, S. V., Schenstrøm, S. M., Christensen, Caspar Elo, Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 111-125Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Structural basis of client specificity in mitochondrial membrane-protein chaperones
Sučec, I., Wang, Y., Dakhlaoui, O., Weinhäupl, K., Jores, T., Costa, D., Hessel, A., Brennich, M., Rapaport, D., Lindorff-Larsen, Kresten, Bersch, B. & Schanda, P., 2020, In: Science Advances. 6, 51, 15 p., eabd0263.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?
Fraser, J. S., Lindorff-Larsen, Kresten & Bonomi, M., 2020, In: Journal of Chemical Information and Modeling. 60, 5, p. 2410-2412 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- 2019
- Published
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Lückmann, Michael, Trauelsen, Mette, Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, Kresten, Schwartz, Thue W. & Frimurer, Thomas Michael, 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PSX, Protein-Solvent Exchange: software for calculation of deuterium-exchange effects in small-angle neutron scattering measurements from protein coordinates
Pedersen, Martin Cramer, Wang, Y., Tidemand, Frederik Grønbæk, Martel, A., Lindorff-Larsen, Kresten & Arleth, Lise, 2019, In: Journal of Applied Crystallography. 52, 6, p. 1427-1436 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Multi-State Coarse-Grained Simulation Model Captures Conformational Cycling in P-Type ATPases
Wang, Y., Saleh, N., Chu, X. & Lindorff-Larsen, Kresten, 2019, In: Biophysical Journal. 116, 3, suppl. 1, p. 300a 1484-Plat.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Allosteric modulation of the sarcoplasmic reticulum Ca2+ ATPase by thapsigargin via decoupling of functional motions
Saleh, N., Wang, Y., Nissen, P. & Lindorff-Larsen, Kresten, 2019, In: Physical Chemistry Chemical Physics. 21, 39, p. 21991-21995Research output: Contribution to journal › Journal article › Research › peer-review
ID: 35228567
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Protein structure validation and refinement using amide proton chemical shifts derived from quantum mechanics
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Similarity measures for protein ensembles
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Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations
Research output: Contribution to journal › Journal article › Research › peer-review