A proximal promoter element required for positive transcriptional control by guanosine tetraphosphate and DKSA protein during the stringent response
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: ppGpp/DksA regulate genes both positively and negatively during stringency. Results: Positive control by ppGpp/DksA is linked to RNA polymerase-promoter saturation kinetics dependent on the promoter's discriminator. Conclusion: Promoters harboring discriminators that make them easily saturated with RNA polymerase are controlled positively by ppGpp/DksA. Significance: The discriminator is a cis-acting element dictating the response of the promoter to alterations in ppGpp/DksA and RNA polymerase availability.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Biological Chemistry |
Vol/bind | 288 |
Udgave nummer | 29 |
Sider (fra-til) | 21055-21064 |
Antal sider | 10 |
ISSN | 0021-9258 |
DOI | |
Status | Udgivet - 19 jul. 2013 |
Eksternt udgivet | Ja |
ID: 165881718