Jacob B. Hansen

Jacob B. Hansen

Associate Professor

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    ORCID: 0000-0001-5249-2586

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    1. Published

      3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

      Shen, J. X., Couchet, M., Dufau, J., de Castro Barbosa, T., Ulbrich, M. H., Helmstädter, M., Kemas, A. M., Zandi Shafagh, R., Marques, M., Hansen, Jacob B., Mejhert, N., Langin, D., Rydén, M. & Lauschke, V. M., 2021, In: Advanced Science. 8, 16, 17 p., 2100106.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      ADD1/SREBP1c activates the PGC1-alpha promoter in brown adipocytes

      Hao, Q., Hansen, Jacob B., Petersen, R. K., Hallenborg, P., Jørgensen, C., Cinti, S., Larsen, P. J., Steffensen, K. R., Wang, H., Collins, S., Wang, J., Gustafsson, J., Madsen, L. & Kristiansen, Karsten, 2010, In: BBA General Subjects. 1801, 4, p. 421-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Activation of peroxisome proliferator-activated receptor gamma bypasses the function of the retinoblastoma protein in adipocyte differentiation

      Hansen, Jacob B., Petersen, R. K., Larsen, B. M., Bartkova, J., Alsner, J. & Kristiansen, K., 1999, In: Journal of Biological Chemistry. 274, 4, p. 2386-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      An adipose lncRAP2-Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

      Alvarez-Dominguez, J. R., Winther, Sally, Hansen, Jacob B., Lodish, H. F. & Knoll, M., 2022, In: iScience. 25, 1, 25 p., 103680.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes

      Isidor, Marie Sophie, Winther, Sally, Basse, A. L., Petersen, M. C. H., Cannon, B., Nedergaard, J. & Hansen, Jacob B., 2016, In: Adipocyte. 5, 2, p. 175-185 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Beta-1 and Not Beta-3 Adrenergic Receptors May Be the Primary Regulator of Human Brown Adipocyte Metabolism

      Riis-Vestergaard, M. J., Richelsen, B., Bruun, J. M., Li, W., Hansen, Jacob B. & Pedersen, S. B., 2020, In: The Journal of clinical endocrinology and metabolism. 105, 4, 12 p., dgz298.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor

      Markussen, L. K., Isidor, Marie Sophie, Breining, P., Andersen, E. S., Rasmussen, N. E., Petersen, L. I., Pedersen, S. B., Richelsen, B. & Hansen, Jacob B., 28 Sep 2017, In: PLoS ONE. 12, 9, 17 p., e0185624.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Deregulated MAPK activity prevents adipocyte differentiation of fibroblasts lacking the retinoblastoma protein.

      Hansen, Jacob B., Petersen, R. K., Jørgensen, C. & Kristiansen, K., 2002, In: Journal of Biological Chemistry. 277, 29, p. 26335-9 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment

      Murholm, M., Dixen, K., Qvortrup, Klaus, Hansen, L. H. L., Amri, E., Madsen, L., Barbatelli, G., Quistorff, B. & Hansen, Jacob B., 2009, In: PLoS ONE. 4, 12, p. e8458

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes

      Dixen, K., Basse, A. L., Murholm, M., Isidor, Marie Sophie, Hansen, L. H. L., Petersen, M. C. H., Madsen, L., Petrovic, N., Nedergaard, J., Quistorff, B. & Hansen, Jacob B., 2013, In: Obesity. 21, 3, p. 516-524 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Editorial overview: New and revitalized old targets in metabolic disease

      Hansen, Jacob B. & Novak, Ivana, 2024, In: Current Opinion in Pharmacology. 75, 3 p., 102434.

      Research output: Contribution to journal › Editorial › Research › peer-review

    12. Published

      Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha.

      Kang, S., Bajnok, L., Longo, K. A., Petersen, R. K., Hansen, Jacob B., Kristiansen, K. & MacDougald, O. A., 2005, In: Molecular and Cellular Biology. 25, 4, p. 1272-82 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Full activation of thermogenesis in brown adipocytes requires Basigin action

      Rupar, K., Isidor, Marie Sophie, Argemi Muntadas, Lidia, Agueda Oyarzabal, Marina, Plucinska, Kaja, Brown, E. L., Mattanovich, M., Bossi, Simone, Tozzi, M., Tandio, David, Petersen, P. S. S., Henriksen, T. I., Trošt, K., Hansen, Jacob B., Gerhart-Hines, Zach, Nielsen, S., Moritz, Thomas & Emanuelli, Brice, 2023, In: F E B S Journal. 290, 10, p. 2673-2691

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.

      Egerod, Kristoffer Lihme, Holst, Birgitte, Petersen, P. S., Hansen, Jacob B., Mulder, J., Hökfelt, T. & Schwartz, Thue W., 2007, In: Molecular Endocrinology. 21, 7, p. 1685-98 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      GSK3 is a negative regulator of the thermogenic program in brown adipocytes

      Markussen, L. K., Winther, Sally, Wicksteed, B. & Hansen, Jacob B., 2018, In: Scientific Reports. 8, p. 1-12 3469.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling

      Basse, A. L., Dixen, K., Yadav, R., Tygesen, M. P., Qvortrup, Klaus, Kristiansen, Karsten, Quistorff, B., Gupta, R., Wang, J. & Hansen, Jacob B., 2015, In: BMC Genomics. 16, 19 p., 215.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Glucagon-like peptide-1 (GLP-1) reduces mortality and improves lung function in a model of experimental obstructive lung disease in female mice

      Viby, N., Isidor, Marie Sophie, Buggeskov, K. B., Poulsen, Steen Seier, Hansen, Jacob B. & Kissow, Hannelouise, 2013, In: Endocrinology. 154, 12, p. 4503-4511 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Inflammatory and metabolic alterations of Kager's fat pad in chronic achilles tendinopathy

      Pingel, Jessica, Petersen, M. C. H., Fredberg, U., Kjær, S. G., Quistorff, B., Langberg, Henning & Hansen, Jacob B., 2015, In: P L o S One. 10, 5, 13 p., e0127811.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

      Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Lipolysis regulates major transcriptional programs in brown adipocytes

      Markussen, L. K., Rondini, E. A., Johansen, O. S., Madsen, J. G. S., Sustarsic, E. G., Marcher, A. B., Hansen, Jacob B., Gerhart-Hines, Zach, Granneman, J. G. & Mandrup, S., 2022, In: Nature Communications. 13, 1, 16 p., 3956.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism

      Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, Marie Sophie, Markussen, L. K., Viuff, B. M., Lambert, Ian Henry, Hansen, Jacob B. & Pedersen, Stine Helene Falsig, 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Many putative endocrine disruptors inhibit prostaglandin synthesis

      Kristensen, D. M., Skalkam, M. L., Audouze, K. M. L., Lesné, L., Desdoits-Lethimonier, C., Frederiksen, H., Brunak, Søren, Skakkebæk, Niels Erik, Jégou, B., Hansen, Jacob B., Junker, S. & Leffers, H., 1 Apr 2011, In: Environmental Health Perspectives. 119, 4, p. 534-41 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Metformin targets brown adipose tissue in vivo and reduces oxygen consumption in vitro

      Breining, P., Jensen, J. B., Sundelin, E. I., Gormsen, L. C., Jakobsen, S., Busk, M., Rolighed, L., Bross, P., Fernandez-Guerra, P., Markussen, L. K., Rasmussen, N. E., Hansen, Jacob B., Pedersen, S. B., Richelsen, B. & Jessen, N., 2018, In: Diabetes, Obesity and Metabolism. 20, 9, p. 2264-2273

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Novel function of the retinoblastoma protein in fat: regulation of white versus brown adipocyte differentiation.

      Hansen, Jacob B., te Riele, H. & Kristiansen, K., 2004, In: Cell Cycle. 3, 6, p. 774-8 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Nutrition restriction in late-gestation and postnatal overfeeding change metabolic preferences in skeletal muscle longissimus dorsi of sheep

      Hou, L., Nilsson, E., Dixen, K., Hansen, Jacob B., Vaag, A. & Nielsen, M. B. O., 2010, Energy and protein metabolism and nutrition: 3th EAAP International Symposium on Energy and Protein Metabolism and Nutrition, Italy, 2010. Crovetto, G. M. (ed.). Wageningen Academic Publishers, p. 187-188 2 p. (EAAP publication; No. 127).

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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