Jacob B. Hansen

Jacob B. Hansen

Associate Professor

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    ORCID: 0000-0001-5249-2586

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    1. Published

      Pyruvate kinase M2 represses thermogenic gene expression in brown adipocytes

      Isidor, Marie Sophie, Winther, Sally, Markussen, L. K., Basse, A. L., Quistorff, B., Nedergaard, J., Emanuelli, Brice & Hansen, Jacob B., 2020, In: FEBS Letters. 594, 7, p. 1218-1225

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes

      Isidor, Marie Sophie, Winther, Sally, Basse, A. L., Petersen, M. C. H., Cannon, B., Nedergaard, J. & Hansen, Jacob B., 2016, In: Adipocyte. 5, 2, p. 175-185 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      The sheep genome illuminates biology of the rumen and lipid metabolism

      Jiang, Y., Xie, M., Chen, W., Talbot, R., Maddox, J. F., Faraut, T., Wu, C., Muzny, D. M., Li, Y., Zhang, W., Stanton, J-A., Brauning, R., Barris, W. C., Hourlier, T., Aken, B. L., Searle, S. M. J., Adelson, D. L., Bian, C., Cam, G. R., Chen, Y. & 53 others, Cheng, S., DeSilva, U., Dixen, K., Dong, Y., Fan, G., Franklin, I. R., Fu, S., Fuentes-Utrilla, P., Guan, R., Highland, M. A., Holder, M. E., Huang, G., Ingham, A. B., Jhangiani, S. N., Kalra, D., Kovar, C. L., Lee, S. L., Liu, W., Liu, X., Lu, C., Lv, T., Mathew, T., McWilliam, S., Menzies, M., Pan, S., Robelin, D., Servin, B., Townley, D., Wang, W., Wei, B., White, S. N., Yang, X., Ye, C., Yue, Y., Zeng, P., Zhou, Q., Hansen, Jacob B., Kristiansen, Karsten, Gibbs, R. A., Flicek, P., Warkup, C. C., Jones, H. E., Oddy, V. H., Nicholas, F. W., McEwan, J. C., Kijas, J. W., Wang, J., Worley, K. C., Archibald, A. L., Cockett, N., Xu, X., Wang, W. & Dalrymple, B. P., 2014, In: Science. 344, 6188, p. 1168-1173 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      The autocrine role of FGF21 in cultured adipocytes

      Justesen, S., Haugegaard, K. V., Hansen, Jacob B., Hansen, Harald S. & Andersen, B., 2020, In: The Biochemical journal. 477, 13, p. 2477-2487 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha.

      Kang, S., Bajnok, L., Longo, K. A., Petersen, R. K., Hansen, Jacob B., Kristiansen, K. & MacDougald, O. A., 2005, In: Molecular and Cellular Biology. 25, 4, p. 1272-82 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      SYK kinase mediates brown fat differentiation and activation

      Knoll, M., Winther, Sally, Natarajan, A., Yang, H., Jiang, M., Thiru, P., Shahsafaei, A., Chavarria, T. E., Lamming, D. W., Sun, L., Hansen, Jacob B. & Lodish, H. F., 13 Dec 2017, In: Nature Communications. 8, 11 p., 2115.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue

      Knudsen, Jakob Grunnet, Murholm, M., Carey, A. L., Biensø, R. S., Basse, A. L., Allen, T. L., Hidalgo, J., Kingwell, B. A., Febbraio, M. A., Hansen, Jacob B. & Pilegaard, Henriette, 2014, In: P L o S One. 9, 1, 8 p., e84910.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Many putative endocrine disruptors inhibit prostaglandin synthesis

      Kristensen, D. M., Skalkam, M. L., Audouze, K. M. L., Lesné, L., Desdoits-Lethimonier, C., Frederiksen, H., Brunak, Søren, Skakkebæk, Niels Erik, Jégou, B., Hansen, Jacob B., Junker, S. & Leffers, H., 1 Apr 2011, In: Environmental Health Perspectives. 119, 4, p. 534-41 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Pocket proteins control white versus brown fat cell differentiation.

      Kristiansen, Karsten & Hansen, Jacob B., 2006, In: Cell Cycle. 5, 4, p. 341-2 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

      Madsen, L., Pedersen, L. M., Lillefosse, H. H., Fjaere, E., Bronstad, I., Hao, Q., Petersen, R. K., Hallenborg, P., Ma, T., De Matteis, R., Araujo, P., Mercader, J., Bonet, M. L., Hansen, J. B., Cannon, B., Nedergaard, J., Wang, J., Cinti, S., Voshol, P., Døskeland, S. O. & 1 others, Kristiansen, Karsten, 30 Jan 2010, In: PLoS ONE. 5, 6, p. 1-13 111391 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      GSK3 is a negative regulator of the thermogenic program in brown adipocytes

      Markussen, L. K., Winther, Sally, Wicksteed, B. & Hansen, Jacob B., 2018, In: Scientific Reports. 8, p. 1-12 3469.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor

      Markussen, L. K., Isidor, Marie Sophie, Breining, P., Andersen, E. S., Rasmussen, N. E., Petersen, L. I., Pedersen, S. B., Richelsen, B. & Hansen, Jacob B., 28 Sep 2017, In: PLoS ONE. 12, 9, 17 p., e0185624.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Lipolysis regulates major transcriptional programs in brown adipocytes

      Markussen, L. K., Rondini, E. A., Johansen, O. S., Madsen, J. G. S., Sustarsic, E. G., Marcher, A. B., Hansen, Jacob B., Gerhart-Hines, Zach, Granneman, J. G. & Mandrup, S., 2022, In: Nature Communications. 13, 1, 16 p., 3956.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Possible link between FSH and RANKL release from adipocytes in men with impaired gonadal function including Klinefelter syndrome

      Mortensen, L. J., Lorenzen, M., Jørgensen, N., Andersson, A., Nielsen, J. E., Petersen, L. I., Lanske, B., Juul, Anders, Hansen, Jacob B. & Jensen, M. B., 2019, In: Bone. 123, p. 103-114

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment

      Murholm, M., Dixen, K., Qvortrup, Klaus, Hansen, L. H. L., Amri, E., Madsen, L., Barbatelli, G., Quistorff, B. & Hansen, Jacob B., 2009, In: PLoS ONE. 4, 12, p. e8458

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes

      Murholm, M., Isidor, Marie Sophie, Basse, A. L., Winther, Sally, Sørensen, C., Skovgaard-Petersen, J., Nielsen, M. M., Hansen, A. S., Quistorff, B. & Hansen, Jacob B., 2013, In: B M C Cell Biology. 14, 41, 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis

      Murholm, M., Dixen, K. & Hansen, Jacob B., 2010, In: BBA General Subjects. 1800, 6, p. 619-627 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      The polycomb group protein Suz12 is required for embryonic stem cell differentiation.

      Pasini, D., Bracken, A. P., Hansen, Jacob B., Capillo, M. & Helin, K., 2007, In: Molecular and Cellular Biology. 27, 10, p. 3769-79 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism

      Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, Marie Sophie, Markussen, L. K., Viuff, B. M., Lambert, Ian Henry, Hansen, Jacob B. & Pedersen, Stine Helene Falsig, 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Inflammatory and metabolic alterations of Kager's fat pad in chronic achilles tendinopathy

      Pingel, Jessica, Petersen, M. C. H., Fredberg, U., Kjær, S. G., Quistorff, B., Langberg, Henning & Hansen, Jacob B., 2015, In: P L o S One. 10, 5, 13 p., e0127811.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Beta-1 and Not Beta-3 Adrenergic Receptors May Be the Primary Regulator of Human Brown Adipocyte Metabolism

      Riis-Vestergaard, M. J., Richelsen, B., Bruun, J. M., Li, W., Hansen, Jacob B. & Pedersen, S. B., 2020, In: The Journal of clinical endocrinology and metabolism. 105, 4, 12 p., dgz298.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Full activation of thermogenesis in brown adipocytes requires Basigin action

      Rupar, K., Isidor, Marie Sophie, Argemi Muntadas, Lidia, Agueda Oyarzabal, Marina, Plucinska, Kaja, Brown, E. L., Mattanovich, M., Bossi, Simone, Tozzi, M., Tandio, David, Petersen, P. S. S., Henriksen, T. I., Trošt, K., Hansen, Jacob B., Gerhart-Hines, Zach, Nielsen, S., Moritz, Thomas & Emanuelli, Brice, 2023, In: F E B S Journal. 290, 10, p. 2673-2691

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

      Shen, J. X., Couchet, M., Dufau, J., de Castro Barbosa, T., Ulbrich, M. H., Helmstädter, M., Kemas, A. M., Zandi Shafagh, R., Marques, M., Hansen, Jacob B., Mejhert, N., Langin, D., Rydén, M. & Lauschke, V. M., 2021, In: Advanced Science. 8, 16, 17 p., 2100106.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure

      Spinelli, S., Cossu, V., Passalacqua, M., Hansen, Jacob B., Guida, L., Magnone, M., Sambuceti, G., Marini, C., Sturla, L. & Zocchi, E., 2023, In: International Journal of Molecular Sciences. 24, 4, 27 p., 3489.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

      Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 8300