Kaare Teilum

Kaare Teilum

Professor

ORCID: 0000-0001-6919-1982

Publication year:
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1 - 50 out of 77Page size: 50
  1. 2024
  2. Published

    A druggable conformational switch in the c-MYC transactivation domain

    Lama, D., Vosselman, T., Sahin, Cagla, Liaño-pons, J., Cerrato, C. P., Nilsson, L., Teilum, Kaare, Lane, D. P., Landreh, M. & Arsenian Henriksson, M., 2024, In: Nature Communications. 15, 1, 14 p., 1865.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Molecular switching in transcription through splicing and proline-isomerization regulates stress responses in plants

    Theisen, Frederik Friis, Prestel, Andreas, Elkjær, Steffie Martina H, Leurs, Y. H. A., Morffy, N., Strader, L. C., O'Shea, Charlotte, Teilum, Kaare, Kragelund, Birthe Brandt & Skriver, Karen, 2024, In: Nature Communications. 15, 1, 13 p., 592.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2023
  5. Published

    Comment on “Intrinsic protein disorder uncouples affinity from binding specificity”

    Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2023, In: Protein Science. 32, 4, 2 p., e4602.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  6. Published

    Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures

    Sahin, Cagla, Motso, A., Gu, X., Feyrer, H., Lama, D., Arndt, T., Rising, A., Gese, G. V., Haellberg, B. M., Marklund, E. G., Schafer, N. P., Petzold, K., Teilum, Kaare, Wolynes, P. G. & Landreh, M., 2023, In: Journal of the American Chemical Society. 145, 19, 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2

    Gavrilov, Y., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2023, In: Protein Science. 32, 4, 9 p., 4604.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. 2022
  9. Published

    Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners

    Christensen, N. R., Pedersen, Christian Parsbæk, Sereikaité, Vita, Pedersen, J. N., Vistrup-Parry, M., Sørensen, Andreas Toft, Otzen, D., Teilum, Kaare, Madsen, Kenneth Lindegaard & Strømgaard, Kristian, 2022, In: iScience. 25, 2, 26 p., 103808.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Disease-linked mutations cause exposure of a protein quality control degron

    Kampmeyer, Caroline, Larsen-Ledet, Sven, Wagnkilde, M. R., Michelsen, M., Iversen, Henriette Kring Mangor, Nielsen, S. V., Lindemose, Søren, Caregnato, A., Ravid, T., Stein, Amelie, Teilum, Kaare, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2022, In: Structure. 30, 9, p. 1245-1253.e5

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Double Mutant of Chymotrypsin Inhibitor 2 Stabilized through Increased Conformational Entropy

    Gavrilov, Y., Kümmerer, Felix, Orioli, S., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2022, In: Biochemistry. 61, 3, p. 160-170 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2021
  13. Published

    A dual-reporter system for investigating and optimizing protein translation and folding in E. coli

    Zutz, A., Hamborg, L., Pedersen, L. E., Kassem, M. M., Papaleo, E., Koza, A., Herrgård, M. J., Ingemann Jensen, S., Teilum, Kaare, Lindorff-Larsen, Kresten & Nielsen, A. T., 2021, In: Nature Communications. 12, 15 p., 6093.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Binding Revisited - Avidity in Cellular Function and Signaling

    qrc243, qrc243 & Teilum, Kaare, 2021, In: Frontiers in Molecular Biosciences. 7, 13 p., 615565.

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry

    Abramsson, M. L., Sahin, C., Hopper, J. T. S., Branca, R. M. M., Danielsson, J., Xu, M., Chandler, S. A., Österlund, N., Ilag, L. L., Leppert, A., Costeira-Paulo, J., Lang, L., Teilum, K., Laganowsky, A., Benesch, J. L. P., Oliveberg, M., Robinson, C. V., Marklund, E. G., Allison, T. M., Winther, J. R. & 1 others, Landreh, M., 2021, In: JACS Au. 1, 12, p. 2385-2393 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Charge Interactions in a Highly Charge-Depleted Protein

    Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Y., Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Fitting Side-Chain NMR Relaxation Data Using Molecular Simulations

    Kümmerer, Felix, Orioli, S., Harding-Larsen, D., Hoffmann, F., Gavrilov, Y., Teilum, Kaare & Lindorff-Larsen, Kresten, 2021, In: Journal of Chemical Theory and Computation. 17, 8, p. 5262-5275 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Linking thermodynamics and measurements of protein stability

    Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Protein engineering, design & selection : PEDS. 34, 13 p., gzab002.

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    On the specificity of protein-protein interactions in the context of disorder

    Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2021, In: Biochemical Journal. 478, 11, p. 2035-2050 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    Software for reconstruction of nonuniformly sampled NMR data

    Pedersen, Christian Parsbæk, Prestel, Andreas & Teilum, Kaare, 2021, In: Magnetic Resonance in Chemistry. 59, 3, p. 315-323 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli

    Hamborg, L., Granata, D., Olsen, Johan Gotthardt, Roche, J. V., Pedersen, L. E., Nielsen, A. T., Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Communications Biology . 4, 9 p., 980.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs

    Lambrughi, M., Maiani, E., Fas, B. A., Shaw, G. S., Kragelund, Birthe Brandt, Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, G. & Papaleo, E., 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 676235.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2020
  24. Published

    A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

    Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, Strømgaard, Kristian, Meehan, Claire Francesca, Vægter, C. B., Gether, Ulrik & Madsen, Kenneth Lindegaard, 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis

    Wu, S., Nguyen, T. T. T. N., Moroz, O. V., Turkenburg, J. P., Nielsen, J. E., Wilson, K. S., Rand, Kasper Dyrberg & Teilum, Kaare, 2020, In: PeerJ. 8, 17 p., e9408.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Global analysis of protein stability by temperature and chemical denaturation

    Hamborg, L., Horsted, E. W., Johansson, Kristoffer Enøe, Willemoës, Martin, Lindorff-Larsen, Kresten & Teilum, Kaare, 2020, In: Analytical Biochemistry. 605, 7 p., 113863.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2019
  28. Published

    Corrigendum: Relax: The analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data (Bioinformatics (2014) DOI: 10.1093/bioinformatics/btu166)

    Morin, S., Linnet, T. E., Lescanne, M., Schanda, P., Thompson, G. S., Tollinger, M., Teilum, Kaare, Gagné, S., Marion, D., Griesinger, C., Blackledge, M. & D'Auvergne, E. J., 15 Oct 2019, In: Bioinformatics. 35, 20, p. 4205 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  29. Published

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    qrc243, qrc243, Thorsen, T. S., Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In: eLife. 8, p. 1-27 e39180.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor

    Nielsen, L. D., Pedersen, Christian Parsbæk, qrc243, qrc243 & Teilum, Kaare, 2019, In: Structure. 27, 7, p. 1071-1081, e1-e5

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

    Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi, Helena, Teilum, Kaare & Ellgaard, Lars, 2019, In: The Journal of Biological Chemistry. 294, 22, p. 8745-8759

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2018
  33. Published

    Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs

    Papaleo, E., Camilloni, C., Teilum, Kaare, Vendruscolo, M. & Lindorff-Larsen, Kresten, 2018, In: PeerJ. 6, p. 1-24 e5125.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor

    Rasmussen, K. K., Falkesgaard, M. H., Winther, M., Roed, N. K., Quistgaard, C. L. A., Teisen, M. N., Edslev, S. M., Petersen, D. L., Aljubouri, A., Christensen, C., Thulstrup, Peter Waaben, Lo Leggio, Leila, Teilum, Kaare & Walmod, P. S., 2018, In: Scientific Reports. 8, 13 p., 8957 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. 2017
  36. Published

    Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness

    Olsen, Johan Gotthardt, Teilum, Kaare & Kragelund, Birthe Brandt, Sep 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3175-3183 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  37. Published

    The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications

    Stiefler-Jensen, D., Schwarz-Linnet, T., de Lichtenberg, C., Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Huang, L., She, Q. & Teilum, Kaare, Sep 2017, In: Protein Science. 26, 9, p. 1819-1827 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae

    Muschiol, S., qrc243, qrc243, Aschtgen, M., Oliveira, V., Schmieder, P., de Lichtenberg, C., Teilum, Kaare, Boesen, T., Akbey, U. & Henriques-Normark, B., 25 Aug 2017, In: Journal of Biological Chemistry. 292, 34, p. 14134-14146 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    (S)Pinning down protein interactions by NMR

    Teilum, Kaare, Kunze, M. B. A., qrc243, qrc243 & Kragelund, Birthe Brandt, Mar 2017, In: Protein Science. 26, 3, p. 436-451 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  40. Published

    Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

    qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+-Aβ Complex

    Somavarapu, A. K., Shen, F., Teilum, Kaare, Zhang, J., Mossin, S., Thulstrup, Peter Waaben, Bjerrum, Morten Jannik, Tiwari, M. K., Szunyogh, D., Søtofte, P. M., Kepp, K. P. & Hemmingsen, Lars Bo Stegeager, 2017, In: Chemistry - A European Journal. 23, 55, p. 13591-13595 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 2016
  43. Published

    A soluble, folded protein without charged amino acid residues

    Højgaard, C., Kofoed, Christian, Espersen, R., Johansson, Kristoffer Enøe, Villa, M., Willemoës, Martin, Lindorff-Larsen, Kresten, Teilum, Kaare & Winther, Jakob R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Amyloid-β and α-synuclein decrease the level of metal-catalyzed reactive oxygen species by radical scavenging and redox silencing

    Pedersen, J. T., Chen, S. W., Borg, C. B., Ness, S., Bahl, J. M., Heegard, N. H. H., Dobson, C. M., Hemmingsen, Lars Bo Stegeager, Cremades, N. & Teilum, Kaare, 2016, In: Journal of the American Chemical Society. 138, 12, p. 3966-3969 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Non-uniform sampling of NMR relaxation data

    Schwarz-Linnet, T. & Teilum, Kaare, 2016, In: Journal of Biomolecular N M R. 64, 2, p. 165-173 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. 2015
  47. Published

    Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering

    Karlsen, M. L., Thorsen, T. S., Johner, N., Ammendrup-Johnsen, I., qrc243, qrc243, Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, Kaare, Vestergaard, Bente, Weinstein, H., Gether, Ulrik, Arleth, Lise & Madsen, Kenneth Lindegaard, 7 Jul 2015, In: Structure. 23, 7, p. 1258-1270 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Aggregation prone amyloid-β⋅CuII Species formed on the millisecond timescale at mildly acidic conditions

    Pedersen, J. T., Borg, C. B., Michaels, T. C. T., Knowles, T. P. J., Faller, P., Teilum, Kaare & Hemmingsen, Lars Bo Stegeager, 2015, In: ChemBioChem. 16, 9, p. 1293-1297 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Globular and disordered-the non-identical twins in protein-protein interactions

    Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2015, In: Frontiers in Bioscience. 2, 6 p., 40.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. 2014
  51. Published

    Binding of Cu2+ to the islet amyloid polypeptide (IAPP)

    Andersen-Usaj, J., Bonde, A. C., Pihl, J., Thomsen, M. F., Shavit, M., Pedersen, J. T., Teilum, Kaare, Thulstrup, Peter Waaben & Hemmingsen, Lars Bo Stegeager, 2014, In: Journal of Biological Inorganic Chemistry. 19, suppl. 2, p. S812 1 p., P 101.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  52. Published

    Helical propensity in an intrinsically disordered protein accelerates ligand binding

    Iesmantavicius, V., Dogan, J., Jemth, P., Teilum, Kaare & Kjærgaard, M., 2014, In: Angewandte Chemie (International ed. in English). 53, 6, p. 1548-1551 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Islet amyloid polypeptide (IAPP)-Structural effects of Zn2+

    Shavit, M., Bonde, A. C., Pihl, J., Thomsen, M. F., Pedersen, J. T., Andersen-Usaj, J., Teilum, Kaare, Hemmingsen, Lars Bo Stegeager & Thulstrup, Peter Waaben, 2014, In: Journal of Biological Inorganic Chemistry. 19, Suppl. 2, p. S813 1 p., P 102.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  54. Published

    Off-resonance rotating-frame relaxation dispersion experiment for 13C in aromatic side chains using L-optimized TROSY-selection

    Weininger, U., Brath, U., Modig, K., Teilum, Kaare & Akke, M., 2014, In: Journal of Biomolecular NMR. 59, 1, p. 23-29 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands

    qrc243, qrc243, Rathje, Mette, Heiðarsson, P. O., Poulsen, F. M., Madsen, Kenneth Lindegaard, Teilum, Kaare & Gether, Ulrik, 2014, In: Journal of Biological Chemistry. 289, 36, p. 25327-25340 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    The pKa value and accessibility of cysteine residues are key determinants for protein substrate discrimination by glutaredoxin

    Jensen, K. S., Pedersen, J. T., Winther, Jakob R. & Teilum, Kaare, 2014, In: Biochemistry. 53, 15, p. 2533-2540 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    pH dependence of amyloid-β-Cu(II) binding and oligomerization kinetics

    Pedersen, J. T., Borg, C. B., Teilum, Kaare & Hemmingsen, Lars Bo Stegeager, 2014, In: Journal of Biological Inorganic Chemistry. 19, Suppl 2, p. S755 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  58. Published

    relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data

    Morin, S., Linnet, T. E., Lescanne, M., Schanda, P., Thompson, G. S., Tollinger, M., Teilum, Kaare, Gagne, S., Marion, D., Griesinger, C., Blackledge, M. & d’Auvergne, E. J., 2014, In: Bioinformatics. 30, 15, p. 2219-2220 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. 2013
  60. Published

    A Folded Excited State of Ligand-Free Nuclear Coactivator Binding Domain (NCBD) Underlies Plasticity in Ligand Recognition.

    Kjaergaard, M., Andersen, L., Nielsen, L. D. & Teilum, Kaare, 2013, In: Biochemistry. 52, 10, p. 1686-1693 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Protein dielectric constants determined from NMR chemical shift perturbations

    Kukic, P., Farrell, D., McIntosh, L. P., García-Moreno E., B., Jensen, K. S., Toleikis, Z., Teilum, Kaare & Nielsen, J. E., 2013, In: Journal of the American Chemical Society. 135, 45, p. 16968–16976 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. 2012
  63. Published

    Is a malleable protein necessarily highly dynamic? The hydrophobic core of the nuclear coactivator binding domain is well ordered

    Kjærgaard, M., Poulsen, F. M. & Teilum, Kaare, 2012, In: Biophysical Journal. 102, 7, p. 1627-1635 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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