Kaare Teilum

Kaare Teilum

Professor

ORCID: 0000-0001-6919-1982

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  1. Published

    Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry

    Abramsson, M. L., Sahin, C., Hopper, J. T. S., Branca, R. M. M., Danielsson, J., Xu, M., Chandler, S. A., Österlund, N., Ilag, L. L., Leppert, A., Costeira-Paulo, J., Lang, L., Teilum, K., Laganowsky, A., Benesch, J. L. P., Oliveberg, M., Robinson, C. V., Marklund, E. G., Allison, T. M., Winther, J. R. & 1 others, Landreh, M., 2021, In: JACS Au. 1, 12, p. 2385-2393 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Binding of Cu2+ to the islet amyloid polypeptide (IAPP)

    Andersen-Usaj, J., Bonde, A. C., Pihl, J., Thomsen, M. F., Shavit, M., Pedersen, J. T., Teilum, Kaare, Thulstrup, Peter Waaben & Hemmingsen, Lars Bo Stegeager, 2014, In: Journal of Biological Inorganic Chemistry. 19, suppl. 2, p. S812 1 p., P 101.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  3. Published

    The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region

    Christensen, L. C., Jensen, N. W., Lages Lino Vala, A., Kamarauskaite, J., Johansson, L. C., Winther, Jakob R., Hofmann, K., Teilum, Kaare & Ellgaard, Lars, 2012, In: Journal of Biological Chemistry. 287, 31, p. 26388-26399 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

    Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, Strømgaard, Kristian, Meehan, Claire Francesca, Vægter, C. B., Gether, Ulrik & Madsen, Kenneth Lindegaard, 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners

    Christensen, N. R., Pedersen, Christian Parsbæk, Sereikaité, Vita, Pedersen, J. N., Vistrup-Parry, M., Sørensen, Andreas Toft, Otzen, D., Teilum, Kaare, Madsen, Kenneth Lindegaard & Strømgaard, Kristian, 2022, In: iScience. 25, 2, 26 p., 103808.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor

    Dagil, Robert, Knudsen, M. J., Olsen, Johan Gotthardt, O'Shea, Charlotte, Franzmann, M., Goffin, V., Teilum, Kaare, Breinholt, J. & Kragelund, Birthe Brandt, 2012, In: Structure. 20, 2, p. 270-282 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

    qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Binding Revisited - Avidity in Cellular Function and Signaling

    qrc243, qrc243 & Teilum, Kaare, 2021, In: Frontiers in Molecular Biosciences. 7, 13 p., 615565.

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands

    qrc243, qrc243, Rathje, Mette, Heiðarsson, P. O., Poulsen, F. M., Madsen, Kenneth Lindegaard, Teilum, Kaare & Gether, Ulrik, 2014, In: Journal of Biological Chemistry. 289, 36, p. 25327-25340 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    qrc243, qrc243, Thorsen, T. S., Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In: eLife. 8, p. 1-27 e39180.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2

    Gavrilov, Y., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2023, In: Protein Science. 32, 4, 9 p., 4604.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Double Mutant of Chymotrypsin Inhibitor 2 Stabilized through Increased Conformational Entropy

    Gavrilov, Y., Kümmerer, Felix, Orioli, S., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2022, In: Biochemistry. 61, 3, p. 160-170 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Solution structures of human and porcine beta-microseminoprotein

    Ghasriani, H., Teilum, Kaare, Johnsson, Y., Fernlund, P. & Drakenberg, T., 2006, In: Journal of Molecular Biology. 362, 3, p. 502-15 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Global analysis of protein stability by temperature and chemical denaturation

    Hamborg, L., Horsted, E. W., Johansson, Kristoffer Enøe, Willemoës, Martin, Lindorff-Larsen, Kresten & Teilum, Kaare, 2020, In: Analytical Biochemistry. 605, 7 p., 113863.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli

    Hamborg, L., Granata, D., Olsen, Johan Gotthardt, Roche, J. V., Pedersen, L. E., Nielsen, A. T., Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Communications Biology . 4, 9 p., 980.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Structure of soybean seed coat peroxidase: a plant peroxidase with unusual stability and haem-apoprotein interactions

    Henriksen, A., Mirza, Osman Asghar, Indiani, C., Teilum, Kaare, Smulevich, G., Welinder, K. G. & Gajhede, Michael, 2001, In: Protein Science. 10, 1, p. 108-15 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Charge Interactions in a Highly Charge-Depleted Protein

    Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Y., Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    A soluble, folded protein without charged amino acid residues

    Højgaard, C., Kofoed, Christian, Espersen, R., Johansson, Kristoffer Enøe, Villa, M., Willemoës, Martin, Lindorff-Larsen, Kresten, Teilum, Kaare & Winther, Jakob R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Helical propensity in an intrinsically disordered protein accelerates ligand binding

    Iesmantavicius, V., Dogan, J., Jemth, P., Teilum, Kaare & Kjærgaard, M., 2014, In: Angewandte Chemie (International ed. in English). 53, 6, p. 1548-1551 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Millisecond dynamics in glutaredoxin during catalytic turnover is dependent on substrate binding and absent in the resting states

    Jensen, K. S., Winther, Jakob R. & Teilum, Kaare, 2011, In: Journal of the American Chemical Society. 133, 9, p. 3034-42 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The pKa value and accessibility of cysteine residues are key determinants for protein substrate discrimination by glutaredoxin

    Jensen, K. S., Pedersen, J. T., Winther, Jakob R. & Teilum, Kaare, 2014, In: Biochemistry. 53, 15, p. 2533-2540 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Disease-linked mutations cause exposure of a protein quality control degron

    Kampmeyer, Caroline, Larsen-Ledet, Sven, Wagnkilde, M. R., Michelsen, M., Iversen, Henriette Kring Mangor, Nielsen, S. V., Lindemose, Søren, Caregnato, A., Ravid, T., Stein, Amelie, Teilum, Kaare, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2022, In: Structure. 30, 9, p. 1245-1253.e5

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering

    Karlsen, M. L., Thorsen, T. S., Johner, N., Ammendrup-Johnsen, I., qrc243, qrc243, Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, Kaare, Vestergaard, Bente, Weinstein, H., Gether, Ulrik, Arleth, Lise & Madsen, Kenneth Lindegaard, 7 Jul 2015, In: Structure. 23, 7, p. 1258-1270 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    A Folded Excited State of Ligand-Free Nuclear Coactivator Binding Domain (NCBD) Underlies Plasticity in Ligand Recognition.

    Kjaergaard, M., Andersen, L., Nielsen, L. D. & Teilum, Kaare, 2013, In: Biochemistry. 52, 10, p. 1686-1693 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Is a malleable protein necessarily highly dynamic? The hydrophobic core of the nuclear coactivator binding domain is well ordered

    Kjærgaard, M., Poulsen, F. M. & Teilum, Kaare, 2012, In: Biophysical Journal. 102, 7, p. 1627-1635 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

    Kjærgaard, M., Teilum, Kaare & Poulsen, F. M., 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 28, p. 12535-40 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Protein dielectric constants determined from NMR chemical shift perturbations

    Kukic, P., Farrell, D., McIntosh, L. P., García-Moreno E., B., Jensen, K. S., Toleikis, Z., Teilum, Kaare & Nielsen, J. E., 2013, In: Journal of the American Chemical Society. 135, 45, p. 16968–16976 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Fitting Side-Chain NMR Relaxation Data Using Molecular Simulations

    Kümmerer, Felix, Orioli, S., Harding-Larsen, D., Hoffmann, F., Gavrilov, Y., Teilum, Kaare & Lindorff-Larsen, Kresten, 2021, In: Journal of Chemical Theory and Computation. 17, 8, p. 5262-5275 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    A druggable conformational switch in the c-MYC transactivation domain

    Lama, D., Vosselman, T., Sahin, Cagla, Liaño-pons, J., Cerrato, C. P., Nilsson, L., Teilum, Kaare, Lane, D. P., Landreh, M. & Arsenian Henriksson, M., 2024, In: Nature Communications. 15, 1, 14 p., 1865.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs

    Lambrughi, M., Maiani, E., Fas, B. A., Shaw, G. S., Kragelund, Birthe Brandt, Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, G. & Papaleo, E., 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 676235.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein

    Lindorff-Larsen, K., Kristjansdottir, S., Teilum, Kaare, Fieber, W., Dobson, C. M., Poulsen, F. M. & Vendruscolo, M., 2004, In: Journal of the American Chemical Society. 126, 10, p. 3291-3219 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Linking thermodynamics and measurements of protein stability

    Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Protein engineering, design & selection : PEDS. 34, 13 p., gzab002.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Fractional 13C enrichment of isolated carbons using [1-13C]- or [2- 13C]-glucose facilitates the accurate measurement of dynamics at backbone Calpha and side-chain methyl positions in proteins

    Lundström, P., Teilum, Kaare, Carstensen, T., Bezsonova, I., Wiesner, S., Hansen, D. F., Religa, T. L., Akke, M. & Kay, L. E., 2007, In: Journal of Biomolecular NMR. 38, 3, p. 199-212 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Protein folding: Defining a standard set of experimental conditions and a preliminary kinetic data set of two-state proteins

    Maxwell, K. L., Wildes, D., Zarrine-Afsar, A., Rivos, M. A. D. L. R., Brown, A. G., Friel, C. T., Hedberg, L., Horng, J-C., Bona, D., Miller, E. J., Vallée-Bélisle, A., Main, E. R. G., Bemporad, F., Qiu, L., Teilum, K., Vu, N-D., Edwards, A. M., Ruczinski, I., Poulsen, F. M., Kragelund, B. B. & 14 others, Michnick, S. W., Chiti, F., Bai, Y., Hagen, S. J., Serrano, L., Oliveberg, M., Raleigh, D. P., Stafshede, P. W., Radford, S. E., Jackson, S. E., Sosnick, T. R., Margusee, S., Davidson, A. R. & Plaxco, K. W., 2005, In: Protein Science. 14, 3, p. 602-616

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data

    Morin, S., Linnet, T. E., Lescanne, M., Schanda, P., Thompson, G. S., Tollinger, M., Teilum, Kaare, Gagne, S., Marion, D., Griesinger, C., Blackledge, M. & d’Auvergne, E. J., 2014, In: Bioinformatics. 30, 15, p. 2219-2220 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Corrigendum: Relax: The analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data (Bioinformatics (2014) DOI: 10.1093/bioinformatics/btu166)

    Morin, S., Linnet, T. E., Lescanne, M., Schanda, P., Thompson, G. S., Tollinger, M., Teilum, Kaare, Gagné, S., Marion, D., Griesinger, C., Blackledge, M. & D'Auvergne, E. J., 15 Oct 2019, In: Bioinformatics. 35, 20, p. 4205 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  37. Published

    Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae

    Muschiol, S., qrc243, qrc243, Aschtgen, M., Oliveira, V., Schmieder, P., de Lichtenberg, C., Teilum, Kaare, Boesen, T., Akbey, U. & Henriques-Normark, B., 25 Aug 2017, In: Journal of Biological Chemistry. 292, 34, p. 14134-14146 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

    Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi, Helena, Teilum, Kaare & Ellgaard, Lars, 2019, In: The Journal of Biological Chemistry. 294, 22, p. 8745-8759

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor

    Nielsen, L. D., Pedersen, Christian Parsbæk, qrc243, qrc243 & Teilum, Kaare, 2019, In: Structure. 27, 7, p. 1071-1081, e1-e5

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness

    Olsen, Johan Gotthardt, Teilum, Kaare & Kragelund, Birthe Brandt, Sep 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3175-3183 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  41. Published

    Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification.

    Ostergaard, L., Teilum, Kaare, Mirza, Osman Asghar, Mattsson, O., Petersen, M., Welinder, K. G., Mundy, J., Gajhede, Michael & Henriksen, A., 2000, In: Plant Molecular Biology. 44, 2, p. 231-43 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs

    Papaleo, E., Camilloni, C., Teilum, Kaare, Vendruscolo, M. & Lindorff-Larsen, Kresten, 2018, In: PeerJ. 6, p. 1-24 e5125.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Software for reconstruction of nonuniformly sampled NMR data

    Pedersen, Christian Parsbæk, Prestel, Andreas & Teilum, Kaare, 2021, In: Magnetic Resonance in Chemistry. 59, 3, p. 315-323 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  44. Published

    pH dependence of amyloid-β-Cu(II) binding and oligomerization kinetics

    Pedersen, J. T., Borg, C. B., Teilum, Kaare & Hemmingsen, Lars Bo Stegeager, 2014, In: Journal of Biological Inorganic Chemistry. 19, Suppl 2, p. S755 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  45. Published

    Amyloid-β and α-synuclein decrease the level of metal-catalyzed reactive oxygen species by radical scavenging and redox silencing

    Pedersen, J. T., Chen, S. W., Borg, C. B., Ness, S., Bahl, J. M., Heegard, N. H. H., Dobson, C. M., Hemmingsen, Lars Bo Stegeager, Cremades, N. & Teilum, Kaare, 2016, In: Journal of the American Chemical Society. 138, 12, p. 3966-3969 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Rapid formation of a preoligomeric peptide-metal-peptide complex following copper(II) binding to amyloid β peptides

    Pedersen, J. T., Teilum, Kaare, Heegaard, N. H. H., Østergaard, Jesper, Adolph, H. & Hemmingsen, Lars Bo Stegeager, 2011, In: Angewandte Chemie International Edition. 50, 11, p. 2532-2535 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  47. Published

    Aggregation prone amyloid-β⋅CuII Species formed on the millisecond timescale at mildly acidic conditions

    Pedersen, J. T., Borg, C. B., Michaels, T. C. T., Knowles, T. P. J., Faller, P., Teilum, Kaare & Hemmingsen, Lars Bo Stegeager, 2015, In: ChemBioChem. 16, 9, p. 1293-1297 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor

    Rasmussen, K. K., Falkesgaard, M. H., Winther, M., Roed, N. K., Quistgaard, C. L. A., Teisen, M. N., Edslev, S. M., Petersen, D. L., Aljubouri, A., Christensen, C., Thulstrup, Peter Waaben, Lo Leggio, Leila, Teilum, Kaare & Walmod, P. S., 2018, In: Scientific Reports. 8, 13 p., 8957 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Solution structure of the second Fibronectin type-III module of NCAM2

    Rasmussen, K. K., Teilum, Kaare, Kulahin, N., Clausen, O., Berezin, V., Bock, E. M., Walmod, P. S. & Poulsen, F., 2009

    Research output: Non-textual form › Dataset › Research

  50. Published

    Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures

    Sahin, Cagla, Motso, A., Gu, X., Feyrer, H., Lama, D., Arndt, T., Rising, A., Gese, G. V., Haellberg, B. M., Marklund, E. G., Schafer, N. P., Petzold, K., Teilum, Kaare, Wolynes, P. G. & Landreh, M., 2023, In: Journal of the American Chemical Society. 145, 19, 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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