Kresten Lindorff-Larsen
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
- 2024
- Published
A mutational atlas for Parkin proteostasis
Clausen, L., Voutsinos, Vasileios, Cagiada, Matteo, Johansson, Kristoffer Enøe, Grønbæk-Thygesen, Martin, Nariya, S., Powell, R. L., Have, M. K. N., Østergaard, Vibe Hallundbæk, Stein, Amelie, Fowler, D. M., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Nature Communications. 15, 1, 17 p., 1541.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay
Gersing, S., Schulze, Thea Klarsø, Cagiada, Matteo, Stein, Amelie, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Genome Biology. 25, 1, 22 p., 98.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational ensembles of the human intrinsically disordered proteome
Tesei, Giulio, Trolle, A. I., Jonsson, Nicolas, Betz, J., Knudsen, F. E., Pesce, Francesco, Johansson, Kristoffer Enøe & Lindorff-Larsen, Kresten, 2024, In: Nature. 626, p. 897-904 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FRETpredict: a Python package for FRET efficiency predictions using rotamer libraries
Montepietra, D., Tesei, Giulio, Martins, J. M., Kunze, M. B. A., Best, R. B. & Lindorff-Larsen, Kresten, 2024, In: Communications Biology . 7, 1, 10 p., 298.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GMMA Can Stabilize Proteins Across Different Functional Constraints
Daffern, N., Johansson, Kristoffer Enøe, Baumer, Z. T., Robertson, N. R., Woojuh, J., Bedewitz, M. A., Davis, Z., Wheeldon, I., Cutler, S. R., Lindorff-Larsen, Kresten & Whitehead, T. A., 2024, In: Journal of Molecular Biology. 436, 11, 15 p., 168586.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Fitting Force Field Parameters to NMR Relaxation Data
Kümmerer, Felix, Orioli, S. & Lindorff-Larsen, Kresten, 5 Jun 2023, In: Journal of Chemical Theory and Computation. 19, 12, p. 3741-3751 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A comprehensive map of human glucokinase variant activity
Gersing, S., Cagiada, Matteo, Gebbia, M., Gjesing, A. P., Coté, A. G., Seesankar, G., Li, R., Tabet, D., Weile, J., Stein, Amelie, Gloyn, A. L., Hansen, Torben, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Genome Biology. 24, 1, 23 p., 97.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accurate protein stability predictions from homology models
Valanciute, A., Nygaard, L., Zschach, Henrike, Maglegaard Jepsen, M., Lindorff-Larsen, Kresten & Stein, Amelie, 2023, In: Computational and Structural Biotechnology Journal. 21, p. 66-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation and substrate specificity of the human P4-ATPase ATP8B1
Dieudonné, T., Kümmerer, Felix, Laursen, M. J., Stock, C., Flygaard, R. K., Khalid, S., Lenoir, G., Lyons, J. A., Lindorff-Larsen, Kresten & Nissen, P., 2023, In: Nature Communications. 14, 1, 14 p., 7492.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins
Pesce, Francesco, Newcombe, Estella Anne, Seiffert, P., Tranchant, E. E., Olsen, Johan Gotthardt, Grace, C. R., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2023, In: Biophysical Journal. 122, 2, p. 310-321 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combining Experiments and Simulations to Examine the Temperature-Dependent Behavior of a Disordered Protein
Pesce, Francesco & Lindorff-Larsen, Kresten, 2023, In: Journal of Physical Chemistry B. 127, 28, p. 6277-6286 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations
Thomasen, Emil, Cuneo, M. J., Mittag, T. & Lindorff-Larsen, Kresten, 2023, In: eLife. 12, 23 p., e84147.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovering functionally important sites in proteins
Cagiada, Matteo, Bottaro, S., Lindemose, Søren, Schenstrøm, S. M., Stein, Amelie, Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2023, In: Nature Communications. 14, 1, 13 p., 4175.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Folding of heterologous proteins in bacterial cell factories: Cellular mechanisms and engineering strategies
Rong, Y., Jensen, S. I., Lindorff-Larsen, Kresten & Nielsen, A. T., 2023, In: Biotechnology Advances. 63, 21 p., 108079.Research output: Contribution to journal › Review › Research › peer-review
- Published
Global analysis of multi-mutants to improve protein function
Johansson, Kristoffer Enøe, Lindorff-Larsen, Kresten & Winther, Jakob R., 2023, In: Journal of Molecular Biology. 435, 8, 15 p., 168034.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HSP70-binding motifs function as protein quality control degrons
Abildgaard, A. B., Voutsinos, Vasileios, Petersen, S. D., Larsen, Fia Brunsgaard Valsted, Kampmeyer, Caroline, Johansson, Kristoffer Enøe, Stein, Amelie, Ravid, T., Andréasson, C., Jensen, M. K., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Cellular and Molecular Life Sciences. 80, 1, 17 p., 32.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved predictions of phase behaviour of intrinsically disordered proteins by tuning the interaction range
Tesei, Giulio & Lindorff-Larsen, Kresten, 2023, In: Open Research Europe. 2, 94, 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insights into the conservation and diversification of the molecular functions of YTHDF proteins
Flores-Téllez, D., Tankmar, Mathias Due, von Bülow, Sören, Chen, Junyu, Lindorff-Larsen, Kresten, Brodersen, Peter & Arribas Hernandez, Laura, 2023, In: PLOS Genetics. 19, 10, 37 p., e1010980.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrated NMR/Molecular Dynamics Determination of the Ensemble Conformation of a Thermodynamically Stable CUUG RNA Tetraloop
Oxenfarth, A., Kümmerer, Felix, Bottaro, S., Schnieders, R., Pinter, G., Jonker, H. R. A., Fürtig, B., Richter, C., Blackledge, M., Lindorff-Larsen, Kresten & Schwalbe, H., 2023, In: Journal of the American Chemical Society. 145, 30, p. 16557-16572 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interpreting the molecular mechanisms of disease variants in human transmembrane proteins
Tiemann, Johanna Katarina Sofie, Zschach, Henrike, Lindorff-Larsen, Kresten & Stein, Amelie, 2023, In: Biophysical Journal. 122, 11, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lynch syndrome, molecular mechanisms and variant classification
Abildgaard, A. B., Nielsen, S., Bernstein, I., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: British Journal of Cancer. 128, 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6-methyladenosine-containing RNA virus
Martínez-Pérez, M., Aparicio, F., Arribas Hernandez, Laura, Tankmar, Mathias Due, Rennie, Sarah, von Bülow, Sören, Lindorff-Larsen, Kresten, Brodersen, Peter & Pallas, V., 2023, In: EMBO Journal. 42, 18, 17 p., e113378.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prediction of Quality-control Degradation Signals in Yeast Proteins
Johansson, Kristoffer Enøe, Mashahreh, B., Hartmann-Petersen, Rasmus, Ravid, T. & Lindorff-Larsen, Kresten, 2023, In: Journal of Molecular Biology. 435, 2, 9 p., 167915.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid protein stability prediction using deep learning representations
Blaabjerg, Lasse Møller, Kassem, M. M., Good, L. L., Jonsson, Nicolas, Cagiada, Matteo, Johansson, Kristoffer Enøe, Boomsma, Wouter, Stein, Amelie & Lindorff-Larsen, Kresten, 2023, In: eLife. 12, 19 p., e82593.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare Catechol-O-methyltransferase Missense Variants Are Structurally Unstable Proteasome Targets
Larsen, Fia Brunsgaard Valsted, Cagiada, Matteo, Dideriksen, J., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Biochemistry. 62, 8, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2
Gavrilov, Y., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2023, In: Protein Science. 32, 4, 9 p., 4604.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of linker conformation on performance and stability of a two-domain lytic polysaccharide monooxygenase
Forsberg, Z., Stepnov, A. A., Tesei, Giulio, Wang, Y., Buchinger, E., Kristiansen, S. K., Aachmann, F. L., Arleth, Lise, Eijsink, V. G. H., Lindorff-Larsen, Kresten & Courtade, G., 2023, In: Journal of Biological Chemistry. 299, 11, 17 p., 105262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation
Chhabra, Y., Seiffert, P., Gormal, R. S., Vullings, M., Lee, C. M. M., Wallis, T. P., Dehkhoda, F., Indrakumar, S., Jacobsen, Nina Louise, Lindorff-Larsen, Kresten, Durisic, N., Waters, M. J., Meunier, F. A., Kragelund, Birthe Brandt & Brooks, A. J., 2023, In: Cell Reports. 42, 5, 26 p., 112490.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
WASCO: A Wasserstein-based Statistical Tool to Compare Conformational Ensembles of Intrinsically Disordered Proteins
González-Delgado, J., Sagar, A., Zanon, C., Lindorff-Larsen, Kresten, Bernadó, P., Neuvial, P. & Cortés, J., 2023, In: Journal of Molecular Biology. 435, 14, 11 p., 168053.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes
Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, , 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A structural biology community assessment of AlphaFold2 applications
Akdel, M., Pires, D. E., Porta Pardo, E., Jänes, J., Zalevsky, A. O., Meszaros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., Shenoy, A., Zhu, W., Kundrotas, P., Serra, V. R., Rodrigues, C. H. M., Dunham, A. S., Burke, D., Borkakoti, N., Velankar, S., Frost, A. & 14 others, , 2022, In: Nature Structural & Molecular Biology. 29, 11, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system
Koivisto, J. M., Poulsen, N. R., Larsen, B. S., Weibull, M. G. M., Stein, Amelie, Doro, F., Winther, Jakob R., Lindorff-Larsen, Kresten & Willemoës, Martin, 2022, In: The Biochemical journal. 479, 4, p. 479-501Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins
Thomasen, Emil & Lindorff-Larsen, Kresten, 2022, In: Biochemical Society Transactions. 50, 1, p. 541-554 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Conserved conformational dynamics determine enzyme activity
Torgeson, K. R., Clarkson, M. W., Granata, D., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 2022, In: Science Advances. 8, 31, 10 p., eabo5546.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conserved degronome features governing quality control associated proteolysis
Mashahreh, B., Armony, S., Johansson, Kristoffer Enøe, Chappleboim, A., Friedman, N., Gardner, R. G., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Ravid, T., 2022, In: Nature Communications. 13, 1, 13 p., 7588.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity
Neumann, C., Rosenbæk, L. L., Flygaard, R. K., Habeck, M., Karlsen, J. L., Wang, Y., Lindorff-Larsen, Kresten, Gad, H. H., Hartmann, R., Lyons, J. A., Fenton, R. A. & Nissen, P., 2022, In: EMBO Journal. 41, 23, 15 p., e110169.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties
Roesgaard, M. A., Lundsgaard, J. E., Newcombe, Estella Anne, Jacobsen, Nina Louise, Pesce, Francesco, Tranchant, E. E., Lindemose, Søren, Prestel, Andreas, Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2022, In: Biomolecules. 12, 10, 19 p., 1426.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disease-linked mutations cause exposure of a protein quality control degron
Kampmeyer, Caroline, Larsen-Ledet, Sven, Wagnkilde, M. R., Michelsen, M., Iversen, Henriette Kring Mangor, Nielsen, S. V., Lindemose, Søren, Caregnato, A., Ravid, T., Stein, Amelie, Teilum, Kaare, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2022, In: Structure. 30, 9, p. 1245-1253.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Double Mutant of Chymotrypsin Inhibitor 2 Stabilized through Increased Conformational Entropy
Gavrilov, Y., Kümmerer, Felix, Orioli, S., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2022, In: Biochemistry. 61, 3, p. 160-170 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
Pacheco-Garcia, J. L., Cagiada, Matteo, Tienne-Matos, K., Salido, E., Lindorff-Larsen, Kresten & L. Pey, A., 2022, In: Frontiers in Molecular Biosciences. 9, 17 p., 1063620.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
Gaggero, S., Martinez-Fabregas, J., Cozzani, A., Fyfe, P. K., Leprohon, M., Yang, J., Thomasen, F. E., Winkelmann, H., Magnez, R., Conti, A. G., Wilmes, S., Pohler, E., van Gijsel Bonnello, M., Thuru, X., Quesnel, B., Soncin, F., Piehler, J., Lindorff-Larsen, K., Roychoudhuri, R., Moraga, I. & 1 others, , 2022, In: Science immunology. 7, 78, 15 p., eade5686.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improving Martini 3 for Disordered and Multidomain Proteins
Thomasen, Emil, Pesce, Francesco, Roesgaard, M. A., Tesei, Giulio & Lindorff-Larsen, Kresten, 2022, In: Journal of Chemical Theory and Computation. 18, 4, p. 2033-2041 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increasing protein stability by inferring substitution effects from high-throughput experiments
Norrild, R. K., Johansson, Kristoffer Enøe, O'Shea, Charlotte, Morth, J. P., Lindorff-Larsen, Kresten & Winther, Jakob R., 2022, In: Cell Reports Methods. 2, 11, 11 p., 100333.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
Johansen, Nicolai Tidemand, Bonaccorsi, M., Bengtsen, T., Nørgrd Larsen, Andreas, Tidemand, Frederik Grønbæk, Pedersen, Martin Cramer, Huda, P., Berndtsson, J., Darwish, T., Yepuri, N. R., Martel, A., Pomorski, Thomas Guenther, Bertarello, A., Sansom, M., Rapp, M., Crehuet, R., Schubeis, T., Lindorff-Larsen, Kresten, Pintacuda, G. & Arleth, Lise, 2022, In: eLife. 11, 35 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation
Høie, M. H., Cagiada, Matteo, Frederiksen, A. H. B., Stein, Amelie & Lindorff-Larsen, Kresten, 2022, In: Cell Reports. 38, 2, 15 p., 110207.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21
Svenningsen, E. B., Ottosen, R. N., Jørgensen, K. H., Nisavic, M., Larsen, C. K., Hansen, B. K., Wang, Y., Lindorff-Larsen, Kresten, Tørring, T., Hacker, S. M., Palmfeldt, J. & Poulsen, T. B., 2022, In: RSC Chemical Biology. 3, 10, p. 1216-1229 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of water coordination in the pH-dependent gating of hAQP10
Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transient exposure of a buried phosphorylation site in an autoinhibited protein
Orioli, S., Henning Hansen, C. G. & Lindorff-Larsen, Kresten, 2022, In: Biophysical Journal. 121, 1, p. 91-101 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
VM i molekylære puslespil
Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 16 Apr 2021, In: Weekendavisen: Ideer. 15, p. 11Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
ID: 35228567
Most downloads
-
2308
downloads
Protein structure validation and refinement using amide proton chemical shifts derived from quantum mechanics
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
911
downloads
Similarity measures for protein ensembles
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
847
downloads
Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations
Research output: Contribution to journal › Journal article › Research › peer-review