Kresten Lindorff-Larsen
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
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Lynch syndrome, molecular mechanisms and variant classification
Abildgaard, A. B., Nielsen, S., Bernstein, I., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: British Journal of Cancer. 128, 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
Abildgaard, A. B., Andersen, Sarah Gersing, Larsen-Ledet, Sven, Nielsen, S. V., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: Biomolecules. 10, 8, 24 p., 1141.Research output: Contribution to journal › Review › Research › peer-review
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Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome
Abildgaard, A. B., Stein, Amelie, Nielsen, S. V., Schultz-Knudsen, Katrine, Papaleo, E., Shrikhande, A., Hoffmann, Eva, Bernstein, I., Gerdes, Anne-Marie Axø, Takahashi, M., Ishioka, C., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2019, In: eLife. 8, 28 p., e49138 .Research output: Contribution to journal › Journal article › Research › peer-review
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HSP70-binding motifs function as protein quality control degrons
Abildgaard, A. B., Voutsinos, Vasileios, Petersen, S. D., Larsen, Fia Brunsgaard Valsted, Kampmeyer, Caroline, Johansson, Kristoffer Enøe, Stein, Amelie, Ravid, T., Andréasson, C., Jensen, M. K., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Cellular and Molecular Life Sciences. 80, 1, 17 p., 32.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolution i overhalingsbanen
Abildgaard, A. B., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Winther, Jakob R., 15 Dec 2017, In: Weekendavisen. 2017, 50, p. Ideer: 13 1 p.Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
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Molekylære stavefejl
Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 28 Jan 2021, In: Weekendavisen, Ideer.Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
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VM i molekylære puslespil
Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 16 Apr 2021, In: Weekendavisen: Ideer. 15, p. 11Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
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Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods
Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.Research output: Contribution to journal › Journal article › Research › peer-review
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Computing, Analyzing, and Comparing the Radius of Gyration and Hydrodynamic Radius in Conformational Ensembles of Intrinsically Disordered Proteins
Ahmed, M. C., Crehuet, R. & Lindorff-Larsen, Kresten, 2020, Intrinsically Disordered Proteins: Methods and Protocols. Kragelund, B. B. & Skriver, K. (eds.). Humana Press, p. 429-445 17 p. (Methods in Molecular Biology, Vol. 2141).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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How well do force fields capture the strength of salt bridges in proteins?
Ahmed, M. C. H., Papaleo, E. & Lindorff-Larsen, Kresten, 2018, In: PeerJ. 6, 17 p., 4967.Research output: Contribution to journal › Journal article › Research › peer-review
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A structural biology community assessment of AlphaFold2 applications
Akdel, M., Pires, D. E., Porta Pardo, E., Jänes, J., Zalevsky, A. O., Meszaros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., Shenoy, A., Zhu, W., Kundrotas, P., Serra, V. R., Rodrigues, C. H. M., Dunham, A. S., Burke, D., Borkakoti, N., Velankar, S., Frost, A. & 14 others, , 2022, In: Nature Structural & Molecular Biology. 29, 11, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.Research output: Contribution to journal › Journal article › Research › peer-review
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Small-angle Neutron Scattering Shows that the Solution Structures of the Bacterial Mg2+-Channel CorA are Overall Similar with and without Mg2+ Bound
Arleth, Lise, Johansen, Nicolai Tidemand, Bengtsen, T., Larsen, A. H., Tidemand, Frederik Grønbæk, Pomorski, Thomas Guenther & Lindorff-Larsen, Kresten, 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl. 1, p. 12A 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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A Combined Simulation and SAXS Study of the Dynamics of Lipid Nanodiscs
Bengtsen, T., Holm-Janas, Viktor, Midtgaard, S. R., Arleth, Lise & Lindorff-Larsen, Kresten, 17 Feb 2018, In: Biophysical Journal. 114, 3, Supp. 1, p. 559A-559A 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations.
Bengtsen, T., Midtgaard, S. R., Holm-Janas, Viktor, Kjølbye, L. R., Johansen, Nicolai Tidemand, Tesei, Giulio, Bottaro, S., Schiøtt, B., Arleth, Lise & Lindorff-Larsen, Kresten, 30 Jul 2020, In: eLife. 9, 24 p., e56518.Research output: Contribution to journal › Journal article › Research › peer-review
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Relation between native ensembles and experimental structures of proteins.
Best, R. B., Lindorff-Larsen, Kresten, DePristo, M. A. & VEndruscolo, M., 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 29, p. 10901-6Research output: Contribution to journal › Journal article › Research › peer-review
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Editorial overview: Theory and simulation: Interpreting experimental data at the molecular level
Best, R. B. & Lindorff-Larsen, Kresten, 2018, In: Current Opinion in Structural Biology. 49, p. iv-v 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Rapid protein stability prediction using deep learning representations
Blaabjerg, Lasse Møller, Kassem, M. M., Good, L. L., Jonsson, Nicolas, Cagiada, Matteo, Johansson, Kristoffer Enøe, Boomsma, Wouter, Stein, Amelie & Lindorff-Larsen, Kresten, 2023, In: eLife. 12, 19 p., e82593.Research output: Contribution to journal › Journal article › Research › peer-review
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Promoting transparency and reproducibility in enhanced molecular simulations
Bonomi, M., Bussi, G., Camilloni, C., Tribello, G. A., Banas, P., Barducci, A., Bernetti, M., Bolhuis, P. G., Bottaro, S., Branduardi, D., Capelli, R., Carloni, P., Ceriotti, M., Cesari, A., Chen, H., Chen, W., Colizzi, F., De, S., De La Pierre, M., Donadio, D. & 54 others, , 2019, In: Nature Methods. 16, 8, p. 670-673Research output: Contribution to journal › Editorial › Research › peer-review
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A sticky cage can slow down folding
Boomsma, Wouter & Lindorff-Larsen, Kresten, 2013, In: Biophysical Journal. 104, 5, p. 964-965 2 p.Research output: Contribution to journal › Comment/debate › Research
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PHAISTOS: a framework for Markov chain Monte Carlo simulation and inference of protein structure
Boomsma, Wouter, Frellsen, J., Harder, T. P., Bottaro, S., Johansson, Kristoffer Enøe, Tian, P., Stovgaard, K., Andreetta, C., Olsson, S., Valentin, J., Antonov, L. D., Christensen, A. S., Borg, M., Jensen, Jan Halborg, Lindorff-Larsen, Kresten, Ferkinghoff-Borg, J. & Hamelryck, Thomas Wim, 2013, In: Journal of Computational Chemistry. 34, 19, p. 1697-1705 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases
Boomsma, Wouter, Nielsen, S. V., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus & Ellgaard, Lars, 2016, In: PeerJ. 4, 18 p., e1725.Research output: Contribution to journal › Journal article › Research › peer-review
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Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts
Boomsma, Wouter, Tian, P., Frellsen, J., Ferkinghoff-Borg, J., Hamelryck, Thomas Wim, Lindorff-Larsen, Kresten & Vendruscolo, M., 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13852-13857 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Combining experiments and simulations using the maximum entropy principle
Boomsma, Wouter, Ferkinghoff-Borg, J. & Lindorff-Larsen, Kresten, 2014, In: PLoS Computational Biology. 10, 2, 9 p., e1003406.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational ensembles of RNA oligonucleotides from integrating NMR and molecular simulations
Bottaro, S., Bussi, G., Kennedy, S. D., Turner, D. H. & Lindorff-Larsen, Kresten, 18 May 2018, In: Science Advances. 4, 5, 8 p., eaar8521.Research output: Contribution to journal › Journal article › Research › peer-review
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Integrating NMR and simulations reveals motions in the UUCG tetraloop
Bottaro, S., Nichols, P. J., Vögeli, B., Parrinello, M. & Lindorff-Larsen, Kresten, 2020, In: Nucleic Acids Research. 48, 11, p. 5839-5848 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Barnaba: software for analysis of nucleic acid structures and trajectories
Bottaro, S., Bussi, G., Pinamonti, G., Reisser, S., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2019, In: RNA. 25, 2, p. 219-231Research output: Contribution to journal › Journal article › Research › peer-review
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Variational optimization of an all-atom implicit solvent force field to match explicit solvent simulation data
Bottaro, S., Lindorff-Larsen, Kresten & Best, R. B., 2013, In: Journal of Chemical Theory and Computation. 9, 12, p. 5641-5652 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational Ensembles of Noncoding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations
Bottaro, S., Bussi, G. & Lindorff-Larsen, Kresten, 2021, In: Journal of the American Chemical Society. 143, 22, p. 8333-8343Research output: Contribution to journal › Journal article › Research › peer-review
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Mapping the universe of RNA tetraloop folds
Bottaro, S. & Lindorff-Larsen, Kresten, 25 Jul 2017, In: Biophysical Journal. 113, 2, p. 257-267 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biophysical experiments and biomolecular simulations: a perfect match?
Bottaro, S. & Lindorff-Larsen, Kresten, 2018, In: Science. 361, 6400, p. 355-360 6 p.Research output: Contribution to journal › Review › Research › peer-review
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Integrating Molecular Simulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach
Bottaro, S., Bengtsen, T. & Lindorff-Larsen, Kresten, 2020, Structural Bioinformatics: Methods and Protocols. Gáspári, Z. (ed.). Humana Press, p. 219-240 22 p. (Methods in Molecular Biology, Vol. 2112).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
Bouchard, J. J., Otero, J. H., Scott, D. C., Szulc, E., Martin, E. W., Sabri, N., Granata, D., Marzahn, M. R., Lindorff-Larsen, Kresten, Salvatella, X., Schulman, B. A. & Mittag, T., 2018, In: Molecular Cell. 72, 1, p. 19-36, e1-e8Research output: Contribution to journal › Journal article › Research › peer-review
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Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
Boyhus, L. E., Danielsen, Mia, Bengtson, N. S., Kunze, M. B. A., Kubiak, X., Sminia, T. J., Løper, J. H., Tran, P. T., Lindorff-Larsen, Kresten, Rasmussen, Søren Gøgsig Faarup, Mathiesen, Jesper M. & Pedersen, D. S., 2018, In: RSC Advances. 8, 4, p. 2219-2228 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A combined computational and structural model of the full-length human prolactin receptor
Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, Johan Gotthardt, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2016, In: Nature Communications. 7, 11 p., 11578.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploiting hydrophobicity for efficient production of transmembrane helices for structure determination by NMR spectroscopy
Bugge, K. Ø., Steinocher, H., Brooks, A. J., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2015, In: Analytical Chemistry. 87, 18, p. 9126–9131 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Understanding single-pass transmembrane receptor signaling from a structural viewpoint—what are we missing?
Bugge, K. Ø., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Dec 2016, In: The FEBS Journal. 283, 24, p. 4424-4451 28 p.Research output: Contribution to journal › Review › Research › peer-review
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Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance
Cagiada, Matteo, Johansson, Kristoffer Enøe, Valanciute, A., Nielsen, S. V., Hartmann-Petersen, Rasmus, Yang, J. J., Fowler, D. M., Stein, Amelie & Lindorff-Larsen, Kresten, 2021, In: Molecular Biology and Evolution. 38, 8, p. 3235-3246Research output: Contribution to journal › Journal article › Research › peer-review
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Discovering functionally important sites in proteins
Cagiada, Matteo, Bottaro, S., Lindemose, Søren, Schenstrøm, S. M., Stein, Amelie, Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2023, In: Nature Communications. 14, 1, 13 p., 4175.Research output: Contribution to journal › Journal article › Research › peer-review
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Fitting Corrections to an RNA Force Field Using Experimental Data
Cesari, A., Bottaro, S., Lindorff-Larsen, Kresten, Banás, P., Sponer, J. & Bussi, G., 2019, In: Journal of Chemical Theory and Computation. 15, 6, p. 3425-3431Research output: Contribution to journal › Journal article › Research › peer-review
Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition
Chandran, V., Stollar, E. J., Lindorff-Larsen, Kresten, Harper, J. F., Chazin, W. J., Dobson, C. M., Luisi, B. F. & Christodoulou, J., 2006, In: Journal of Molecular Biology. 357, 2, p. 400-10 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation
Chhabra, Y., Seiffert, P., Gormal, R. S., Vullings, M., Lee, C. M. M., Wallis, T. P., Dehkhoda, F., Indrakumar, S., Jacobsen, Nina Louise, Lindorff-Larsen, Kresten, Durisic, N., Waters, M. J., Meunier, F. A., Kragelund, Birthe Brandt & Brooks, A. J., 2023, In: Cell Reports. 42, 5, 26 p., 112490.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery
Choy, M. S., Li, Y., Machado, L. E. S. F., Kunze, M. B. A., Connors, C. R., Wei, X., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 16 Feb 2017, In: Molecular Cell. 65, 4, p. 644-658 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein structure validation and refinement using amide proton chemical shifts derived from quantum mechanics
Christensen, A. S., Linnet, T. E., Borg, M., Boomsma, Wouter, Lindorff-Larsen, Kresten, Hamelryck, Thomas Wim & Jensen, Jan Halborg, 2013, In: PLoS ONE. 8, 12, 10 p., e84123.Research output: Contribution to journal › Journal article › Research › peer-review
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Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation
Bjørnkjær, Lene, Stein, Amelie, Grønbæk-Thygesen, Martin, Nygaard, L., Søltoft, C. L., Nielsen, S. V., Lisby, Michael, Ravid, T., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: PLOS Genetics. 16, 11, 28 p., e1009187.Research output: Contribution to journal › Journal article › Research › peer-review
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A mutational atlas for Parkin proteostasis
Clausen, L., Voutsinos, Vasileios, Cagiada, Matteo, Johansson, Kristoffer Enøe, Grønbæk-Thygesen, Martin, Nariya, S., Powell, R. L., Have, M. K. N., Østergaard, Vibe Hallundbæk, Stein, Amelie, Fowler, D. M., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Nature Communications. 15, 1, 17 p., 1541.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein stability and degradation in health and disease
Bjørnkjær, Lene, Abildgaard, A. B., Gersing, S. K., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2019, Molecular Chaperones in Human Disorders. Donev, R. (ed.). Academic Press, p. 61-83 (Advances in Protein Chemistry and Structural Biology, Vol. 114).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Bayesian-Maximum-Entropy Reweighting of IDP Ensembles Based on NMR Chemical Shifts
Crehuet, R., Buigues, P. J., Salvatella, X. & Lindorff-Larsen, Kresten, 2019, In: Entropy. 21, 9, 17 p., 898.Research output: Contribution to journal › Journal article › Research › peer-review
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GMMA Can Stabilize Proteins Across Different Functional Constraints
Daffern, N., Johansson, Kristoffer Enøe, Baumer, Z. T., Robertson, N. R., Woojuh, J., Bedewitz, M. A., Davis, Z., Wheeldon, I., Cutler, S. R., Lindorff-Larsen, Kresten & Whitehead, T. A., 2024, In: Journal of Molecular Biology. 436, 11, 15 p., 168586.Research output: Contribution to journal › Journal article › Research › peer-review
Mapping Long-Range Interactions in a-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations
Dedmon, M. M., Lindorff-Larsen, Kresten, Christodoulou, J., Vendruscolo, M. & Dobson, C. M., 2005, In: Journal of the American Chemical Society. 127, 2, p. 476-477Research output: Contribution to journal › Journal article › Research › peer-review
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Activation and substrate specificity of the human P4-ATPase ATP8B1
Dieudonné, T., Kümmerer, Felix, Laursen, M. J., Stock, C., Flygaard, R. K., Khalid, S., Lenoir, G., Lyons, J. A., Lindorff-Larsen, Kresten & Nissen, P., 2023, In: Nature Communications. 14, 1, 14 p., 7492.Research output: Contribution to journal › Journal article › Research › peer-review
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Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo, A., Topal, B., Kunze, M. B. A., Aranda, J., Chiesa, G., Mungianu, D., Bernardo-Seisdedos, G., Eftekharzadeh, B., Gairí, M., Pierattelli, R., Felli, I. C., Diercks, T., Millet, O., García, J., Orozco, M., Crehuet, R., Lindorff-Larsen, Kresten & Salvatella, X., 2019, In: Nature Communications. 10, 11 p., 2034.Research output: Contribution to journal › Journal article › Research › peer-review
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Insights into the conservation and diversification of the molecular functions of YTHDF proteins
Flores-Téllez, D., Tankmar, Mathias Due, von Bülow, Sören, Chen, Junyu, Lindorff-Larsen, Kresten, Brodersen, Peter & Arribas Hernandez, Laura, 2023, In: PLOS Genetics. 19, 10, 37 p., e1010980.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of linker conformation on performance and stability of a two-domain lytic polysaccharide monooxygenase
Forsberg, Z., Stepnov, A. A., Tesei, Giulio, Wang, Y., Buchinger, E., Kristiansen, S. K., Aachmann, F. L., Arleth, Lise, Eijsink, V. G. H., Lindorff-Larsen, Kresten & Courtade, G., 2023, In: Journal of Biological Chemistry. 299, 11, 17 p., 105262.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the residual structure in the unfolded state of the Delta 131 Delta fragment of staphylococcal nuclease
Francis, C. J., Lindorff-Larsen, Kresten, Best, R. B. & Bendruscolo, M., 2006, In: Proteins - Structure Function and Bioinformatics. 65, 1, p. 145-52Research output: Contribution to journal › Journal article › Research › peer-review
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What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?
Fraser, J. S., Lindorff-Larsen, Kresten & Bonomi, M., 2020, In: Journal of Chemical Information and Modeling. 60, 5, p. 2410-2412 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
Gaggero, S., Martinez-Fabregas, J., Cozzani, A., Fyfe, P. K., Leprohon, M., Yang, J., Thomasen, F. E., Winkelmann, H., Magnez, R., Conti, A. G., Wilmes, S., Pohler, E., van Gijsel Bonnello, M., Thuru, X., Quesnel, B., Soncin, F., Piehler, J., Lindorff-Larsen, K., Roychoudhuri, R., Moraga, I. & 1 others, , 2022, In: Science immunology. 7, 78, 15 p., eade5686.Research output: Contribution to journal › Journal article › Research › peer-review
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Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2
Gavrilov, Y., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2023, In: Protein Science. 32, 4, 9 p., 4604.Research output: Contribution to journal › Journal article › Research › peer-review
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Double Mutant of Chymotrypsin Inhibitor 2 Stabilized through Increased Conformational Entropy
Gavrilov, Y., Kümmerer, Felix, Orioli, S., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2022, In: Biochemistry. 61, 3, p. 160-170 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
BPPred: a Web-based computational tool for predicting biophysical parameters of proteins
Geierhaas, C. D., Nickson, A. A., Lindorff-Larsen, Kresten, Clarke, J. & Vendruscolo, M., 2007, In: Protein Science. 16, 1, p. 125-34 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A comprehensive map of human glucokinase variant activity
Andersen, Sarah Gersing, Cagiada, Matteo, Gebbia, M., Gjesing, A. P., Coté, A. G., Seesankar, G., Li, R., Tabet, D., Weile, J., Stein, Amelie, Gloyn, A. L., Hansen, Torben, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Genome Biology. 24, 1, 23 p., 97.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterizing glucokinase variant mechanisms using a multiplexed abundance assay
Gersing, S., Schulze, Thea Klarsø, Cagiada, Matteo, Stein, Amelie, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Genome Biology. 25, 1, 22 p., 98.Research output: Contribution to journal › Journal article › Research › peer-review
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Mapping the degradation pathway of a disease-linked aspartoacylase variant
Andersen, Sarah Gersing, Wang, Y., Grønbæk-Thygesen, Martin, Kampmeyer, Caroline, Bjørnkjær, Lene, Willemoës, Martin, Andréasson, C., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2021, In: PLOS Genetics. 17, 4, 28 p., e1009539.Research output: Contribution to journal › Journal article › Research › peer-review
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14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes
Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, , 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
WASCO: A Wasserstein-based Statistical Tool to Compare Conformational Ensembles of Intrinsically Disordered Proteins
González-Delgado, J., Sagar, A., Zanon, C., Lindorff-Larsen, Kresten, Bernadó, P., Neuvial, P. & Cortés, J., 2023, In: Journal of Molecular Biology. 435, 14, 11 p., 168053.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global analysis of protein stability by temperature and chemical denaturation
Hamborg, L., Horsted, E. W., Johansson, Kristoffer Enøe, Willemoës, Martin, Lindorff-Larsen, Kresten & Teilum, Kaare, 2020, In: Analytical Biochemistry. 605, 7 p., 113863.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli
Hamborg, L., Granata, D., Olsen, Johan Gotthardt, Roche, J. V., Pedersen, L. E., Nielsen, A. T., Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Communications Biology . 4, 9 p., 980.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)
Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the Calculation of SAXS Profiles of Folded and Intrinsically Disordered Proteins from Computer Simulations
Henriques, J., Arleth, Lise, Lindorff-Larsen, Kresten & Skepo, M., 3 Aug 2018, In: Journal of Molecular Biology. 430, 16, SI, p. 2521-2539Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein Dynamics Enables Phosphorylation of Buried Residues in Cdk2/Cyclin-A-Bound p27
Henriques, J. & Lindorff-Larsen, Kresten, 2020, In: Biophysical Journal. 119, 10, p. 2010-2018 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Charge Interactions in a Highly Charge-Depleted Protein
Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Y., Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation
Høie, M. H., Cagiada, Matteo, Frederiksen, A. H. B., Stein, Amelie & Lindorff-Larsen, Kresten, 2022, In: Cell Reports. 38, 2, 15 p., 110207.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A soluble, folded protein without charged amino acid residues
Højgaard, C., Kofoed, Christian, Espersen, R., Johansson, Kristoffer Enøe, Villa, M., Willemoës, Martin, Lindorff-Larsen, Kresten, Teilum, Kaare & Winther, Jakob R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Communication routes in ARID domains between distal residues in Helix 5 and the DNA-binding loops
Invernizzi, G., Tiberti, M., Lambrughi, M., Lindorff-Larsen, Kresten & Papaleo, E., 2014, In: P L o S Computational Biology (Online). 10, 9, 13 p., e1003744.Research output: Contribution to journal › Journal article › Research › peer-review
Principles of conduction and hydrophobic gating in K+ channels
Jensen, M. Ø., Borhani, D. W., Lindorff-Larsen, Kresten, Maragakis, P., Jogini, V., Eastwood, M. P., Dror, R. O. & Shaw, D. E., 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 13, p. 5833-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Force Field Effects in Simulations of Flexible Peptides with Varying Polyproline II Propensity
Jephthah, S., Pesce, Francesco, Lindorff-Larsen, Kresten & Skepö, M., 2021, In: Journal of Chemical Theory and Computation. 17, 10, p. 6634-6646 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Classifying disease-associated variants using measures of protein activity and stability
Jepsen, M. M., Fowler, D. M., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 91-107Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
Johansen, Nicolai Tidemand, Bonaccorsi, M., Bengtsen, T., Nørgrd Larsen, Andreas, Tidemand, Frederik Grønbæk, Pedersen, Martin Cramer, Huda, P., Berndtsson, J., Darwish, T., Yepuri, N. R., Martel, A., Pomorski, Thomas Guenther, Bertarello, A., Sansom, M., Rapp, M., Crehuet, R., Schubeis, T., Lindorff-Larsen, Kresten, Pintacuda, G. & Arleth, Lise, 2022, In: eLife. 11, 35 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global analysis of multi-mutants to improve protein function
Johansson, Kristoffer Enøe, Lindorff-Larsen, Kresten & Winther, Jakob R., 2023, In: Journal of Molecular Biology. 435, 8, 15 p., 168034.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prediction of Quality-control Degradation Signals in Yeast Proteins
Johansson, Kristoffer Enøe, Mashahreh, B., Hartmann-Petersen, Rasmus, Ravid, T. & Lindorff-Larsen, Kresten, 2023, In: Journal of Molecular Biology. 435, 2, 9 p., 167915.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural heterogeneity and dynamics in protein evolution and design
Johansson, Kristoffer Enøe & Lindorff-Larsen, Kresten, 2018, In: Current Opinion in Structural Biology. 48, p. 157-163 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template
Johansson, Kristoffer Enøe, Johansen, Nicolai Tidemand, Christensen, S., Horowitz, S., Bardwell, J. C. A., Olsen, Johan Gotthardt, Willemoës, Martin, Lindorff-Larsen, Kresten, Ferkinghoff-Borg, J., Hamelryck, Thomas Wim & Winther, Jakob R., 2016, In: Journal of Molecular Biology. 428, 21, p. 4361-4377 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blocking protein quality control to counter hereditary cancers
Kampmeyer, Caroline, Nielsen, S. V., Bjørnkjær, Lene, Stein, Amelie, Gerdes, Anne-Marie Axø, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, Dec 2017, In: Genes, Chromosomes & Cancer. 56, 12, p. 823-831 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Disease-linked mutations cause exposure of a protein quality control degron
Kampmeyer, Caroline, Larsen-Ledet, Sven, Wagnkilde, M. R., Michelsen, M., Iversen, Henriette Kring Mangor, Nielsen, S. V., Lindemose, Søren, Caregnato, A., Ravid, T., Stein, Amelie, Teilum, Kaare, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2022, In: Structure. 30, 9, p. 1245-1253.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel HARS2 missense variants identified in individuals with sensorineural hearing impairment and Perrault syndrome
Karstensen, H. G., Rendtorff, N. D., Hindbæk, L. S., Colombo, R., Stein, Amelie, Birkebæk, N. H., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten, Højland, A. T., Petersen, M. B. & Tranebjærg, Lisbeth, 2020, In: European Journal of Medical Genetics. 63, 3, 6 p., 103733.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts
Kassem, M. M., Christoffersen, L. B., Cavalli, A. & Lindorff-Larsen, Kresten, 2018, In: Scientific Reports. 8, 11112.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of the bacterial cytoskeleton protein bactofilin by NMR chemical shifts and sequence variation
Kassem, M. M., Wang, Y., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2016, In: Biophysical Journal. 110, 11, p. 2342-2348 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Order and disorder - An integrative structure of the full-length human growth hormone receptor
Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Y., Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.Research output: Contribution to journal › Journal article › Research › peer-review
Long-timescale molecular dynamics simulations of protein structure and function
Klepeis, J. L., Lindorff-Larsen, Kresten, Dror, R. O. & Shaw, D. E., 2009, In: Current Opinion in Structural Biology. 19, 2, p. 120-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks
Koehler Leman, J., Lyskov, S., Lewis, S. M., Adolf-Bryfogle, J., Alford, R. F., Barlow, K., Ben-Aharon, Z., Farrell, D., Fell, J., Hansen, W. A., Harmalkar, A., Jeliazkov, J., Kuenze, G., Krys, J. D., Ljubetič, A., Loshbaugh, A. L., Maguire, J., Moretti, R., Mulligan, V. K., Nance, M. L. & 30 others, , 2021, In: Nature Communications. 12, 15 p., 6947.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system
Koivisto, J. M., Poulsen, N. R., Larsen, B. S., Weibull, M. G. M., Stein, Amelie, Doro, F., Winther, Jakob R., Lindorff-Larsen, Kresten & Willemoës, Martin, 2022, In: The Biochemical journal. 479, 4, p. 479-501Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation of Native and Non-native Interactions in Ensembles of Denatured ACBP Molecules from Paramagnetic Relaxation Enhancement Studies
Kristjansdottir, S., Lindorff-Larsen, Kresten, Fieber, W., Dobson, C. M., Vendruscolo, M. & Poulsen, F. M., 2005, In: Journal of Molecular Biology. 347, 5, p. 1053-1062Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic activation and regulation of the mitogen-activated protein kinase p38
Kumar, G. S., Clarkson, M. W., Kunze, M. B. A., Granata, D., Wand, A. J., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 1 May 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4655-4660 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fitting Force Field Parameters to NMR Relaxation Data
Kümmerer, Felix, Orioli, S. & Lindorff-Larsen, Kresten, 5 Jun 2023, In: Journal of Chemical Theory and Computation. 19, 12, p. 3741-3751 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fitting Side-Chain NMR Relaxation Data Using Molecular Simulations
Kümmerer, Felix, Orioli, S., Harding-Larsen, D., Hoffmann, F., Gavrilov, Y., Teilum, Kaare & Lindorff-Larsen, Kresten, 2021, In: Journal of Chemical Theory and Computation. 17, 8, p. 5262-5275 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs
Lambrughi, M., Maiani, E., Fas, B. A., Shaw, G. S., Kragelund, Birthe Brandt, Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, G. & Papaleo, E., 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 676235.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions
Lambrughi, M., De Gioia, L., Gervasio, F. L., Lindorff-Larsen, Kresten, Nussinov, R., Urani, C., Bruschi, M. & Papaleo, E., 2016, In: Nucleic Acids Research. 44, 19, p. 9096-9109 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution
Nørgrd Larsen, Andreas, Wang, Y., Bottaro, S., Grudinin, S., Arleth, Lise & Lindorff-Larsen, Kresten, 2020, In: P L o S Computational Biology. 16, 4, 29 p., e1007870.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare Catechol-O-methyltransferase Missense Variants Are Structurally Unstable Proteasome Targets
Larsen, Fia Brunsgaard Valsted, Cagiada, Matteo, Dideriksen, J., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Biochemistry. 62, 8, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Protein folding and the organization of the protein topology universe
Lindorff-Larsen, Kresten, Røgen, P., Paci, E., Vendruscolo, M. & Dobson, C. M., 2005, In: TIBS -Trends in Biochemical Sciences. Regular ed.. 30, 1, p. 13-19Research output: Contribution to journal › Journal article › Research
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Protein structure validation and refinement using amide proton chemical shifts derived from quantum mechanics
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Similarity measures for protein ensembles
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Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations
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