Steen Holmberg

Steen Holmberg

Associate Professor emeritus


  1. 2012
  2. Published

    MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.

    Düring, L., Thorsen, M., Petersen, D., Køster, B., Jensen, T. H. & Holmberg, Steen, 2012, In: P L o S One. 7, 9, 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Mediator regulates non-coding RNA transcription at fission yeast centromeres

    Thorsen, M., Hansen, H., Venturi, M., Holmberg, Steen & Thon, Genevieve, 2012, In: Epigenetics & Chromatin. 5, p. 1-10 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2008
  5. Published

    Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways

    Linder, T., Rasmussen, N., Samuelsen, C. O., Chatzidaki, E., Baraznenok, V., Beve, J., Henriksen, P., Gustafsson, C. M. & Holmberg, Steen, 2008, In: Nucleic Acids Research. 36, 8, p. 2489-504 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2006
  7. Published

    Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions

    Zhu, X., Wirén, M., Sinha, I., Rasmussen, N. N., Linder, T., Holmberg, Steen, Ekwall, K. & Gustafsson, C. M., 2006, In: Molecular Cell. 22, 2, p. 169-78 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II

    Elmlund, H., Baraznenok, V., Lindahl, M., Samuelsen, C. O., Koeck, P. J. B., Holmberg, Steen, Hebert, H. & Gustafsson, C. M., 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 43, p. 15788-93 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2004
  10. Published

    A Unified Nomenclature for Protein Subunits of Mediator Complexes Linking Transcriptional Regulators to RNA Polymerase II

    Bourbon, H. M., Aguilera, A., Ansari, A. Z., Asturias, F. J., Berk, A. J., Bjorklund, S., Blackwell, T. K., Borggrefe, T., Carey, M., Carlson, M., Conaway, J. W., Conaway, R. C., Emmons, S. W., Fondell, J. D., Freedman, L. P., Fukasawa, T., Gustafsson, C. M., Han, M., He, X., Herman, P. K. & 27 others, Hinnebusch, A. G., Holmberg, Steen, Holstege, F. C., Jaehning, J. A., Kim, Y., Kuras, L., Leutz, A., Lis, J. T., Meisterernest, M., Naar, A. M., Nasmyth, K., Parvin, J. D., Ptashne, M., Reinberg, D., Ronne, H., Sadowski, I., Sakurai, H., Sipiczki, M., Sternberg, P. W., Stillman, D. J., Strich, R., Struhl, K., Svejstrup, J. Q., Tuck, S., Winston, F., Roeder, R. G. & Kornberg, R. D., 2004, In: Molecular Cell. 14, 5, p. 553-557

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2003
  12. Published

    Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro

    Sphar, H., Khorosjutina, O., Baraznenok, V., Linder, T., Samuelsen, C. O., Hermand, D., Makela, T. P., Holmberg, Steen & Gustafsson, C. M., 2003, In: Journal of Biological Chemistry. 278, p. 51301-51306

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution

    Samuelsen, C. O., Baraznenok, V., Khorosjutina, O., Spahr, H., Kieselbach, T., Holmberg, Steen & Gustafsson, C. M., 2003, In: Proceedings of the National Academy of Science of the United States of America. 100, 11, p. 6422-6427 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2002
  15. Published

    Neither Reblp nor poly(dA-dT) Elements Are Responsible for the Highly Specific Chromatin Organization at the ILV1 Promoter

    Moreira, J. M. A., Hörz, W. & Holmberg, Steen, 2002, In: Journal of Biological Chemistry. 277, p. 3202-3209

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2001
  17. Published

    Schizosacchromyces pombe Mediator defines a set of essential subunits conserved between yeast and metazoan cells

    Spåhr, H., Samuelsen, C. O., Baraznenok, V., Ernest, I., Remacle, J. R., Samuelsson, T., Kieselbach, T., Holmberg, Steen & Gustafsson, C. M., 2001, In: Proceedings of the National Academy of Science of the United States of America. 98, p. 11985-11990

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells

    Spåhr, H., Samuelsen, C. O., Baraznenok, V., Ernest, I., Huylebroeck, D., Remacle, J. E., Samuelsson, T., Kieselbach, T., Holmberg, Steen & Gustafsson, C. M., 2001, In: Proceedings of the National Academy of Science of the United States of America. 98, 21, p. 11985-11990 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Neither Reb1p nor poly(dA*T) elements are responsible for the highly specific chromatin organization at the ILV1 promoter

    Moreira, José, Hörz, W. & Holmberg, Steen, 2001, In: Journal of Biological Chemistry. 277, 5, p. 3202-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Origins of the many NPY-family receptors in mammals

    Larhammar, D., Wraith, A., Berglund, M. M., Holmberg, Steen & Lundell, I., 2001, In: Peptides. 22, 3, p. 295-307 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2000
  22. Published

    Chromatin-mediated transcriptional regulation by the yeast architectural factors NHP6A and NHP6B

    Moreira, José & Holmberg, Steen, 2000, In: EMBO Journal. 19, 24, p. 6804-6813 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 1999
  24. Published

    Substrate specificity and gene expression of the amino acid permeases in Saccharomyces cerevisiae

    Regenberg, Birgitte, Düring-Olsen, L., Kielland-Brandt, M. C. & Holmberg, Steen, 1 Jan 1999, In: Current Genetics. 36, 6, p. 317-328 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Amino acid inducible expression system

    Samuelsen, C. O., Remacle, J. R. & Holmberg, Steen, 1999, European patent application No. 99126058.9.

    Research output: Book/ReportReportCommunication

  26. Published

    Kromatinstruktur og kontrol af genaktivitet

    Holmberg, Steen, 1999, In: Årsberetning Løvens Forskningsfond. 1998, p. 16-17

    Research output: Contribution to journalJournal articleResearch

  27. Published

    Mutations that cause threonine sensitivity identify catalytic and regulatory regions of the aspartate kinase of Saccharomyces cerevisiae

    Arévalo-Rodríguez, M., Calderón, I. L. & Holmberg, Steen, 1999, In: Yeast. 15, 13, p. 1331-45 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae

    Regenberg, B., During-Olsen, L., Kielland-Brandt, M. C. & Holmberg, Steen, 1999, In: Current Genetics. 36, p. 317-328

    Research output: Contribution to journalJournal articleResearch

  29. Published

    Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC

    Moreira, J. M. A. & Holmberg, Steen, 1999, In: EMBO Journal. 18 (10), p. 2836-2844

    Research output: Contribution to journalJournal articleResearch

  30. Published

    Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC

    Moreira, José & Holmberg, Steen, 1999, In: E M B O Journal. 18, 10, p. 2836-44 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Yeast transcriptional regulator Leu3p: Self-masking, specificity of masking, and evidence for regulation by the intracellular level of Leu3p

    Wang, D., Zheng, F., Holmberg, Steen & Kohlhaw, G. B., 1999, In: The Journal of Biological Chemistry. 274 (27), p. 19017-19024

    Research output: Contribution to journalJournal articleResearch

  32. 1998
  33. Published

    A novel esterase from Saccharomyces carlsbergensis, a possible function for the yeast TIP1 gene

    Horsted, M. W., Dey, E. S., Holmberg, Steen & Kielland-Brandt, M. C., 1998, In: Yeast. 14, 9, p. 793-803 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Datin, a yeast poly(dA:dT)-binding protein, behaves as an activator of the wild-type ILV1 promoter and interacts synergistically with Reb1p

    Moreira, José, Remacle, J. E., Kielland-Brandt, M. & Holmberg, Steen, 1998, In: Molecular and General Genetics. 258, 1-2, p. 95-103 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae

    Regenberg, B., Holmberg, Steen, Olsen, L. D. & Kielland-Brandt, M. C., 1998, In: Current Genetics. 33, p. 171-177

    Research output: Contribution to journalJournal articleResearch

  36. Published

    Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae. Engelsk

    Regenberg, Birgitte, Holmberg, Steen, Olsen, L. D. & Kielland-Brandt, M. C., 1998, In: Current Genetics. 33, 3, p. 171-177

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published
  38. Published

    Nucleosome structure of the yeast CHA1 promoter: Analysis of activation-dependent chromatin remodeling of an RNA-polymerase-II-transcribed gene in TBP and RNA pol II mutants ......

    Moreira, J. M. A. & Holmberg, Steen, 1998, In: EMBO Journal. 17 (20), p. 6028-6038

    Research output: Contribution to journalJournal articleResearch

  39. 1997
  40. Published

    Cultivation of yeast cells: Saccharomyces cerevisiae and Schizosaccharomyces pombe

    Egel, R. & Holmberg, Steen, 1997, Cell Biology: A laboratory Handbook, 2nd Ed.. Academic Press, San Diego, Californien, USA, p. 421-430

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  41. Published

    Locus-specific suppression of ilv1 in Saccharomyces cerevisiae by deregulation of CHA1 transcription

    Pedersen, J. Ø., Rodríguez, M. A., Prætorius-Ibba, M., Nilsson-Tillgren, N. T., Calderón, I. L. & Holmberg, Steen, 1997, In: Mol. Gen. Genet.. 255, p. 561-569

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 1996
  43. Published

    Comparative amino acid sequence analysis of the C6 zinc cluster family of transcriptional regulators

    Scherling, P. & Holmberg, Steen, 1996, In: Nucleic Acids Research. 24, p. 4599-4607

    Research output: Contribution to journalJournal articleResearch

  44. 1995
  45. Published

    A region of the aspartokinase in Sacch. cerevisiae involved in the regulation of its enzymatic activity (abstr. 17th Intern. Conf. on Yeast Genetics and Molecular Biology, Lissabon, Portugal, juni 95)

    Arévalo, M., Holmberg, Steen & Calderón, L., 1995, In: Yeast. 11 (special issue), p. S475

    Research output: Contribution to journalJournal articleResearch

  46. Published

    Functional analysis of the CHA4 transcriptional activator protein (abstr. 17th Intern. Conf. on Yeast Genetics and Molecular Biology, Lissabon, Portugal, 10.-16. juni 1995)

    Schjerling, P., Pedersen, J., Winther, K., Baker, H. & Holmberg, Steen, 1995, In: Yeast. 11 (special issue), p. S238

    Research output: Contribution to journalJournal articleResearch

  47. Published

    Genetics of brewing yeasts

    Kielland-Brandt, M., Nilsson-Tillgren, T., Gjermansen, C., Holmberg, Steen & Pedersen, M. B., 1995, The Yeasts. Vol 6. Yeast Genetics (2nd ed). London: Academic Press, p. 223-254

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  48. 1994
  49. Published

    A Reb1p-binding site and a poly(dA) element synergistically control Saccharomyces cerevisiae ILV1 basal level expression. Abstr. GSA-Meeting, Seattle, Calif., USA, 16. - 21. august 1994

    Moreira, J., Remacle, J., Kielland-Brandt, M. & Holmberg, Steen, 1994, 1994 Yeast Genetics and Molecular Biology Meeting. Abstracts Volume. USA, p. 250B

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  50. Published

    Molecular characterization of the yeast transcriptional activator CHA4. Abstr. 1994 Keystone Symposia on Molecular & Cellular Biology, Keystone, Colorado, USA

    Holmberg, Steen & Schjerling, P., 1994, In: J. Cell. Biochem.. 18C, p. L319

    Research output: Contribution to journalJournal articleResearch

  51. Published

    Molecular characterization of the yeast transcriptional activator Cha4p. Abstr. GSA-Meeting, Seattle, Calif., USA, 16. - 21. august 1994

    Schjerling, P. & Holmberg, Steen, 1994, 1994 Yeast Genetics and Molecular Biology Meeting. Abstracts Volume. USA, p. 314A

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  52. 1993
  53. Published

    A regulatory element in the CHA1 promoter which confers inducibility by serine and threonine on Saccharomyces cerevisiae genes

    Bornæs, C., Ignjatovic, M. W., Schjerling, P., Kielland-Brandt, M. C. & Holmberg, Steen, 1993, In: Molecular and Cellular Biology. 12, p. 7604-7611

    Research output: Contribution to journalJournal articleResearch

  54. Published

    Recessive as well as dominant mutations in the yeast transcriptional activator CHA4 can lead to CHA1. Abstract. 1993 Keystone Symposia on Molecular & Cellular Biology, Keystone, Colorado, USA

    Holmberg, Steen, Schjerling, P., Pedersen, J. Ø., Prætorius, M. & Nilsson-Tillgren, T., 1993, In: J. Cell. Biochem.. 17A, p. B352

    Research output: Contribution to journalJournal articleResearch

  55. Published

    Recessive as well as dominant mutations in the yeast transcriptional activator CHA4 can lead to constitutive expression of CHA1. Abstract. GSA-Meeting, Wisconsin, Madison, USA

    Holmberg, Steen, Schjerling, P., Pedersen, J. Ø., Prætorius, M. & Nilsson-Tillgren, T., 1993, 1993 Yeast Genetics and Molecular Biology Meeting. Abstracts Volume. USA, p. 179B

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  56. Published

    Recombination and disjunction of homoeologous chromosomes in Saccharomyces. Abstract. GSA-Meeting, Wisconsin, Madison, USA

    Nilsson-Tillgren, T., Nielsen, T. & Holmberg, Steen, 1993, 1993 Yeast Genetics and Molecular Biology Meeting. Abstracts Volume. USA, p. 150A

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  57. 1992
  58. Published

    A REB1-binding site is required for GCN4-independent ILV1 basal level transcription and can be functionally replaced by an ABF1-binding site

    Remacle, J. E. & Holmberg, Steen, 1992, In: Molecular and Cellular Biology. Vol. 12., No. 12, p. 5516-5526

    Research output: Contribution to journalJournal articleResearch

  59. Published

    Mutants affecting the regulation of catabolism of hydroxy amino acid. Abstr. 16th Intern. Conf. on Yeast Genetics and Molecular Biology, Wien, Østrig, 15.-21. aug. 1992

    Prætorius, M., Pedersen, J. Ø., Nilsson-Tillgren, T. & Holmberg, Steen, 1992, In: Yeast. 8 (special issue), p. S138

    Research output: Contribution to journalJournal articleResearch

  60. Published

    REB1 is required for GCN4-independent ILV1 basal level transcription and can be functionally replaced by ABF1. Abstract. 1992

    Holmberg, Steen & Remacle, J., 1992, In: J. Cell. Biochem.. 16E, p. R426

    Research output: Contribution to journalJournal articleResearch

  61. Published

    Serine and threonine catabolism in Saccharomyces cerevisiae: The CHA1 polypeptide is homologous with other serine and threonine dehydratases

    Bornæs, C., Petersen, J. G. L. & Holmberg, Steen, 1992, In: Genetics. 131, p. 531-539

    Research output: Contribution to journalJournal articleResearch

  62. Published

    Transcriptional control of anabolic and catabolic threonine deaminases in yeast. Abstr. Workshop on Control of Gene Expression in Yeast, Inst. Juan March, Madrid, Spanien, d.14.-16. december 1992

    Holmberg, Steen, 1992, Workshop on Control of Gene Expression in Yeast (Abstract Book). Madrid, Spanien: Instituto Juan March de Estudios e Inv.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  63. 1991
  64. Published

    A REB1 binding element is needed for the ILV1 basal level expression. Abstract. GSA-meeting, San Francisco, Calif.

    Remacle, J., Holmberg, Steen & Kielland-Brandt, M. C., 1991, 1991 Yeast Genetics and Molecular Biology Meeting. Abstracts Volume.. USA, p. 175B

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  65. Published

    Construction of diacetyl-less Saccharomyces carlsbergensis strains by in vitro deletions in ILV2. Abstract. GSA-meeting, San Francisco, Calif., USA

    Gjermansen, C., Kielland-Brandt, M. C., Holmberg, Steen & Nilsson-Tillgren, T., 1991, 1991 Yeast Genetics and Molecular Biology Meeting. Abstracts Volume. USA, p. 147A

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  66. Published

    Evidence for positive regulation of serine and threonine catabolism in Saccharomyces cerevisiae. Abstract GSA-meeting, San Francisco, Calif., USA

    Holmberg, Steen, 1991, 1991 Yeast Genetics and Molecular Biology Meeting. Abstracts Volume.. USA, p. 191A

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  67. 1990
  68. Published

    Breeding of brewers´ yeast

    Tullin, S., Kielland-Brandt, M. C., Nilsson-Tillgren, N. T., Sigsgaard, P. & Holmberg, Steen, 1990, Proc. 5th. Eur. Congr Biotechnol. vol. II. Vol II ed. Copenhagen: Munksgaard , p. 699-702

    Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

  69. Published

    Genetic analysis and breeding of brewers' yeast

    Kielland-Brandt, M., Gjermansen, C., Tullin, S., Nilsson-Tillgren, T., Sigsgaard, P. & Holmberg, Steen, 1990, Proc. GIM 90 - 6th Int. Symp. Genetics of Industrial Microorganisms (Vol. II). Société Francaise de Microbiol.,Fran, p. 877-85

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  70. Published

    Genetic improvement of brewers' yeast

    Kielland-Brandt, M., Gjermansen, C., Tullin, S., Sigsgaard, P., Nilsson-Tillgren, T. & Holmberg, Steen, 1990, Proc. 9th National Scientific and Technical Conf. for Brewing Industry. Sofia, Bulgaria

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  71. Published

    Identification of a DNA element required for basal level (GCN4-independent) transcription of the ILV1 gene of yeast

    Holmberg, Steen, Remacle, J., Kielland-Brandt, M., Petersen, J. G. L. & Nilsson-Tillgren, T., 1990, In: Journal of Cellular Biology. Suppl. 14B, p. E215

    Research output: Contribution to journalJournal articleResearch

  72. Published

    Regulated overproduction and secretion of yeast carboxypeptidase Y

    Nielsen, T. L., Holmberg, Steen & Petersen, J. G. L., 1990, In: Appl. Microbiol. Biotechnol.. 33, p. 307-312

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. 1989
  74. Published

    Sequencing of the CHA1 region proximal to the HML locus

    Bojko, M., Bornæs, C., Rasmussen, S. W., Holmberg, Steen & Petersen, J. G. L., 1989, Proc. BAP Meeting on Sequencing of Yeast Chromosome III, Tutzing, BRD. Bruxelles, p. 28-31

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  75. Published

    Yeast Breeding

    Kielland-Brandt, M. C., Gjermansen, C., Nilsson-Tillgren, N. T. & Holmberg, Steen, 1989.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  76. 1988
  77. Published

    Molecular genetics of serine and threonine catabolism in Saccharomyces cerevisiae

    Petersen, J. G. L., Kielland-Brandt, M. C., Bornæs, C., Nilsson-Tillgren, N. T. & Holmberg, Steen, 1988, In: Genetics. 119, p. 527-534

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae

    Holmberg, Steen & Petersen, J. G. L., 1988, In: Curr Genet. 13, p. 207-17

    Research output: Contribution to journalJournal articleResearch

  79. Published

    Towards diacetyl-less brewer´s yeast. Influence of ilv2 and ilv5 mutations

    Gjermansen, C., Nilsson-Tillgren, N. T., Petersen, J. G. L., Kielland-Brandt, M. C., Sigsgaard, P. & Holmberg, Steen, 1988, In: Journal of Basic Microbiology. 28(3), p. 175-183

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 10048