A comparison of the mechanisms of electrolyte secretion in pancreas and salivary glands

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A comparison of the mechanisms of electrolyte secretion in pancreas and salivary glands. / Case, R. M.; Hunter, M.; Novak, I.; Young, J. A.

In: Scandinavian Journal of Gastroenterology, Supplement, Vol. 18, No. 87, 01.01.1983, p. 57-67.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Case, RM, Hunter, M, Novak, I & Young, JA 1983, 'A comparison of the mechanisms of electrolyte secretion in pancreas and salivary glands', Scandinavian Journal of Gastroenterology, Supplement, vol. 18, no. 87, pp. 57-67.

APA

Case, R. M., Hunter, M., Novak, I., & Young, J. A. (1983). A comparison of the mechanisms of electrolyte secretion in pancreas and salivary glands. Scandinavian Journal of Gastroenterology, Supplement, 18(87), 57-67.

Vancouver

Case RM, Hunter M, Novak I, Young JA. A comparison of the mechanisms of electrolyte secretion in pancreas and salivary glands. Scandinavian Journal of Gastroenterology, Supplement. 1983 Jan 1;18(87):57-67.

Author

Case, R. M. ; Hunter, M. ; Novak, I. ; Young, J. A. / A comparison of the mechanisms of electrolyte secretion in pancreas and salivary glands. In: Scandinavian Journal of Gastroenterology, Supplement. 1983 ; Vol. 18, No. 87. pp. 57-67.

Bibtex

@article{a32bdba3162c4b9f81a34f2ce3d584aa,
title = "A comparison of the mechanisms of electrolyte secretion in pancreas and salivary glands",
abstract = "Many epithelial organs, both absorptive, like the intestine and gall bladder, and secretory, like the pancreas and salivary glands, transport salt and water in isotonic proportions, i.e. in the absence of a substantial trans-epithelial osmotic gradient. It seems reasonable to suggest that the basic mechanisms involved in these transport processes are similar in all such organs. To examine this hypothesis, we have studied the secretion of pancreatic juice by the ducts of the perfused cat pancreas, and the secretion of saliva by the perfused rabbit mandibular gland. We have compared the effects of removing one or more perfusate constituents, or adding pharmacological blocking agents, or both. These studies suggest that a Na+/Cl- carrier and a Na+/H+ carrier (or their equivalent) are responsible for secretion in both glands. In the mandibular gland, the carriers can act independently (i.e. Cl- and HCO3- can each sustain secretion): in the pancreatic ducts they appear to be operationally linked (i.e. Cl- cannot sustain secretion in the absence of HCO3-. What this means in molecular terms remains unknown.",
author = "Case, {R. M.} and M. Hunter and I. Novak and Young, {J. A.}",
year = "1983",
month = jan,
day = "1",
language = "English",
volume = "18",
pages = "57--67",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "87",

}

RIS

TY - JOUR

T1 - A comparison of the mechanisms of electrolyte secretion in pancreas and salivary glands

AU - Case, R. M.

AU - Hunter, M.

AU - Novak, I.

AU - Young, J. A.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Many epithelial organs, both absorptive, like the intestine and gall bladder, and secretory, like the pancreas and salivary glands, transport salt and water in isotonic proportions, i.e. in the absence of a substantial trans-epithelial osmotic gradient. It seems reasonable to suggest that the basic mechanisms involved in these transport processes are similar in all such organs. To examine this hypothesis, we have studied the secretion of pancreatic juice by the ducts of the perfused cat pancreas, and the secretion of saliva by the perfused rabbit mandibular gland. We have compared the effects of removing one or more perfusate constituents, or adding pharmacological blocking agents, or both. These studies suggest that a Na+/Cl- carrier and a Na+/H+ carrier (or their equivalent) are responsible for secretion in both glands. In the mandibular gland, the carriers can act independently (i.e. Cl- and HCO3- can each sustain secretion): in the pancreatic ducts they appear to be operationally linked (i.e. Cl- cannot sustain secretion in the absence of HCO3-. What this means in molecular terms remains unknown.

AB - Many epithelial organs, both absorptive, like the intestine and gall bladder, and secretory, like the pancreas and salivary glands, transport salt and water in isotonic proportions, i.e. in the absence of a substantial trans-epithelial osmotic gradient. It seems reasonable to suggest that the basic mechanisms involved in these transport processes are similar in all such organs. To examine this hypothesis, we have studied the secretion of pancreatic juice by the ducts of the perfused cat pancreas, and the secretion of saliva by the perfused rabbit mandibular gland. We have compared the effects of removing one or more perfusate constituents, or adding pharmacological blocking agents, or both. These studies suggest that a Na+/Cl- carrier and a Na+/H+ carrier (or their equivalent) are responsible for secretion in both glands. In the mandibular gland, the carriers can act independently (i.e. Cl- and HCO3- can each sustain secretion): in the pancreatic ducts they appear to be operationally linked (i.e. Cl- cannot sustain secretion in the absence of HCO3-. What this means in molecular terms remains unknown.

UR - http://www.scopus.com/inward/record.url?scp=0021029557&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0021029557

VL - 18

SP - 57

EP - 67

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 87

ER -

ID: 240420067